听力与言语-语言病理学

行为科学

医学伦理学

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  • Behavioral Effects of 4-CMC and 4-MeO-PVP in DBA/2J Mice After Acute and Intermittent Administration and Following Withdrawal from Intermittent 14-Day Treatment.

    abstract::Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-021-00329-x

    authors: Wojcieszak J,Kuczyńska K,Zawilska JB

    更新日期:2021-01-11 00:00:00

  • Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer's Disease.

    abstract::Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00321-x

    authors: Wang H,Yue Y,Zhao H,Wu H,Jiang K,Li S,Zhao M,Lin F

    更新日期:2021-01-05 00:00:00

  • Simvastatin Prevents Long-Term Cognitive Deficits in Sepsis Survivor Rats by Reducing Neuroinflammation and Neurodegeneration.

    abstract::Sepsis-associated encephalopathy causes brain dysfunction that can result in cognitive impairments in sepsis survivor patients. In previous work, we showed that simvastatin attenuated oxidative stress in brain structures related to memory in septic rats. However, there is still a need to evaluate the long-term impact ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00222-z

    authors: Catalão CHR,Santos-Junior NN,da Costa LHA,Souza AO,Cárnio EC,Sebollela A,Alberici LC,Rocha MJA

    更新日期:2020-12-01 00:00:00

  • Sirt7-p21 Signaling Pathway Mediates Glucocorticoid-Induced Inhibition of Mouse Neural Stem Cell Proliferation.

    abstract::Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00294-x

    authors: Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

    更新日期:2020-10-06 00:00:00

  • 2-Hydroxypropyl-β-cyclodextrin Ototoxicity in Adult Rats: Rapid Onset and Massive Destruction of Both Inner and Outer Hair Cells Above a Critical Dose.

    abstract::2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00252-7

    authors: Liu X,Ding D,Chen GD,Li L,Jiang H,Salvi R

    更新日期:2020-10-01 00:00:00

  • Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex.

    abstract::Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00233-w

    authors: Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

    更新日期:2020-08-01 00:00:00

  • Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

    abstract::Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00231-y

    authors: Thakur V,Jamwal S,Kumar M,Rahi V,Kumar P

    更新日期:2020-08-01 00:00:00

  • Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00258-1

    authors: K C S,Kakoty V,Marathe S,Chitkara D,Taliyan R

    更新日期:2020-07-18 00:00:00

  • Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed in Alzheimer's Disease.

    abstract::Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00161-9

    authors: Yu ZY,Li WW,Yang HM,Mañucat-Tan NB,Wang J,Wang YR,Sun BL,Hu ZC,Zhang LL,Tan L,Deng J,Liu YH

    更新日期:2020-04-01 00:00:00

  • Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities.

    abstract::The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00142-7

    authors: da Silva WMB,de Oliveira Pinheiro S,Alves DR,de Menezes JESA,Magalhães FEA,Silva FCO,Silva J,Marinho ES,de Morais SM

    更新日期:2020-04-01 00:00:00

  • Protective Effects of Carvacrol on Brain Tissue Inflammation and Oxidative Stress as well as Learning and Memory in Lipopolysaccharide-Challenged Rats.

    abstract::Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00144-5

    authors: Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

    更新日期:2020-04-01 00:00:00

  • Contribution of Fc fragment of monoclonal antibodies to tetanus toxin neutralization.

    abstract:BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00124-9

    authors: Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

    更新日期:2020-03-01 00:00:00

  • Correction to: Comparing the Neuroprotective Effects of Caffeic Acid in Rat Cortical Slices and Caenorhabditis elegans: Involvement of Nrf2 and SKN-1 Signaling Pathways.

    abstract::One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12640-019-00153-4

    authors: Colonnello A,Aguilera-Portillo G,Rubio-López LC,Robles-Bañuelos B,Rangel-López E,Cortez-Núñez S,Evaristo-Priego Y,Silva-Palacios A,Galván-Arzate S,García-Contreras R,Túnez I,Chen P,Aschner M,Santamaría A

    更新日期:2020-03-01 00:00:00

  • Diverse Gene Expressions in the Prediction of Cuprizone-Induced Demyelination.

    abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00154-3

    authors: Han SR,Kang YH,Yoo SM,Lee MS,Lee SH

    更新日期:2020-03-01 00:00:00

  • Effect of Combined Prenatal and Adult Benzophenone-3 Dermal Exposure on Factors Regulating Neurodegenerative Processes, Blood Hormone Levels, and Hematological Parameters in Female Rats.

    abstract::Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-020-00163-7

    authors: Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

    更新日期:2020-03-01 00:00:00

  • Salsolinol-neurotoxic or Neuroprotective?

    abstract::Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00118-7

    authors: Kurnik-Łucka M,Latacz G,Martyniak A,Bugajski A,Kieć-Kononowicz K,Gil K

    更新日期:2020-02-01 00:00:00

  • OSU-6162, a Sigma1R Ligand in Low Doses, Can Further Increase the Effects of Cocaine Self-Administration on Accumbal D2R Heteroreceptor Complexes.

    abstract::Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00134-7

    authors: Borroto-Escuela DO,Romero-Fernandez W,Wydra K,Zhou Z,Suder A,Filip M,Fuxe K

    更新日期:2020-02-01 00:00:00

  • Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress.

    abstract::Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00101-2

    authors: Yang CR,Zhang XY,Liu Y,Du JY,Liang R,Yu M,Zhang FQ,Mu XF,Li F,Zhou L,Zhou FH,Meng FJ,Wang S,Ming D,Zhou XF

    更新日期:2020-01-01 00:00:00

  • Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.

    abstract::This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

    journal_title:Neurotoxicity research

    pub_type: 评论,杂志文章

    doi:10.1007/s12640-019-00100-3

    authors: Hansen B

    更新日期:2020-01-01 00:00:00

  • Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats.

    abstract::Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00055-5

    authors: Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler G

    更新日期:2019-11-01 00:00:00

  • Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice.

    abstract::Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00021-1

    authors: Nieoczym D,Socała K,Jedziniak P,Wyska E,Wlaź P

    更新日期:2019-11-01 00:00:00

  • Not Just from Ethanol. Tetrahydroisoquinolinic (TIQ) Derivatives: from Neurotoxicity to Neuroprotection.

    abstract::The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审

    doi:10.1007/s12640-019-00051-9

    authors: Peana AT,Bassareo V,Acquas E

    更新日期:2019-11-01 00:00:00

  • Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK.

    abstract::Aging plays a significant role in the progression of vascular diseases and vascular dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory signals may cause vascular permeability and endothelial leakage. Pro-inflammatory molecules have a significant effect on smooth muscle cells (SM...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审

    doi:10.1007/s12640-019-00047-5

    authors: Uddin MS,Kabir MT,Jakaria M,Mamun AA,Niaz K,Amran MS,Barreto GE,Ashraf GM

    更新日期:2019-10-01 00:00:00

  • The Long-Term Impairment in Redox Homeostasis Observed in the Hippocampus of Rats Subjected to Global Perinatal Asphyxia (PA) Implies Changes in Glutathione-Dependent Antioxidant Enzymes and TIGAR-Dependent Shift Towards the Pentose Phosphate Pathways: Ef

    abstract::We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00064-4

    authors: Lespay-Rebolledo C,Tapia-Bustos A,Bustamante D,Morales P,Herrera-Marschitz M

    更新日期:2019-10-01 00:00:00

  • Quality Control in Huntington's Disease: a Therapeutic Target.

    abstract::Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审

    doi:10.1007/s12640-019-00087-x

    authors: Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

    更新日期:2019-10-01 00:00:00

  • Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal.

    abstract::Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00091-1

    authors: Fürstenau CR,de Souza ICC,de Oliveira MR

    更新日期:2019-10-01 00:00:00

  • Carnosic Acid Pretreatment Attenuates Mitochondrial Dysfunction in SH-SY5Y Cells in an Experimental Model of Glutamate-Induced Excitotoxicity.

    abstract::Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00044-8

    authors: de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

    更新日期:2019-10-01 00:00:00

  • Breakdown of the Paracellular Tight and Adherens Junctions in the Gut and Blood Brain Barrier and Damage to the Vascular Barrier in Patients with Deficit Schizophrenia.

    abstract::Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00054-6

    authors: Maes M,Sirivichayakul S,Kanchanatawan B,Vodjani A

    更新日期:2019-08-01 00:00:00

  • Influence of In Vitro Electrical Stimulation on Survival of Spiral Ganglion Neurons.

    abstract::Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-00017-x

    authors: Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

    更新日期:2019-07-01 00:00:00

  • Effects of Curcumin on Microglial Cells.

    abstract::Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审

    doi:10.1007/s12640-019-00030-0

    authors: Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

    更新日期:2019-07-01 00:00:00

  • Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats.

    abstract::Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross blood brain barrier and received considerable attention for its neuroprotective role. We have reported the benefit of AA against aluminum chloride (AlCl3)-induced amyloid pathology, enhanced acetylcholine esterase (AChE) act...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-9999-2

    authors: Ahmad Rather M,Justin-Thenmozhi A,Manivasagam T,Saravanababu C,Guillemin GJ,Essa MM

    更新日期:2019-05-01 00:00:00

  • Selenium Enhances the Apoptotic Efficacy of Docetaxel Through Activation of TRPM2 Channel in DBTRG Glioblastoma Cells.

    abstract::The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-0009-5

    authors: Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

    更新日期:2019-05-01 00:00:00

  • Correction to: Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats.

    abstract::The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...

    journal_title:Neurotoxicity research

    pub_type: 已发布勘误

    doi:10.1007/s12640-018-9982-3

    authors: Li H,Song S,Wang Y,Huang C,Zhang F,Liu J,Hong JS

    更新日期:2019-05-01 00:00:00

  • Glycyrrhizic Acid Ameliorates Mitochondrial Function and Biogenesis Against Aluminum Toxicity in PC12 Cells.

    abstract::Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-018-9967-2

    authors: Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

    更新日期:2019-04-01 00:00:00

  • Postnatal Administration of Homocysteine Induces Cerebellar Damage in Rats: Protective Effect of Folic Acid.

    abstract::A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-018-9979-y

    authors: Koohpeyma H,Goudarzi I,Elahdadi Salmani M,Lashkarbolouki T,Shabani M

    更新日期:2019-04-01 00:00:00

  • Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.

    abstract::Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-019-0007-7

    authors: Iha HA,Kunisawa N,Shimizu S,Onishi M,Nomura Y,Matsubara N,Iwai C,Ogawa M,Hashimura M,Sato K,Kato M,Ohno Y

    更新日期:2019-04-01 00:00:00

  • Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress.

    abstract::The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-017-9838-2

    authors: Goguadze N,Zhuravliova E,Morin D,Mikeladze D,Maurice T

    更新日期:2019-01-01 00:00:00

  • The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors.

    abstract::Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-018-9912-4

    authors: Schamne MG,Mack JM,Moretti M,Matheus FC,Walz R,Lanfumey L,Prediger RD

    更新日期:2018-11-01 00:00:00

  • Nociceptive Response to L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats.

    abstract::Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-018-9896-0

    authors: Nascimento GC,Bariotto-Dos-Santos K,Leite-Panissi CRA,Del-Bel EA,Bortolanza M

    更新日期:2018-11-01 00:00:00

  • L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.

    abstract::Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章

    doi:10.1007/s12640-018-9905-3

    authors: Lei H,Zhang Y,Huang L,Xu S,Li J,Yang L,Wang L,Xing C,Wang X,Peng Y

    更新日期:2018-10-01 00:00:00

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