A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.

abstract：:Botulinum neurotoxin (BoNT) has been used clinically since 1980, with an ever-increasing range of clinical applications. This has coincided with a period of massively expanded interest in the underlying biology of the neurotoxin. Tremendous advances have taken place in the scientific understanding of neurotoxin struct...

journal_title：Neurotoxicity research

authors： Foster KA,Bigalke H,Aoki KR

更新日期：2006-04-01 00:00:00

abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...

journal_title：Neurotoxicity research

authors： Sadakierska-Chudy A,Filip M

更新日期：2015-02-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

journal_title：Neurotoxicity research

authors： Hansen B

更新日期：2020-01-01 00:00:00

abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...

journal_title：Neurotoxicity research

authors： Bercker S,Bert B,Bittigau P,Felderhoff-Müser U,Bührer C,Ikonomidou C,Weise M,Kaisers UX,Kerner T

更新日期：2009-08-01 00:00:00

abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...

journal_title：Neurotoxicity research

authors： Pountney DL,Treweek TM,Chataway T,Huang Y,Chegini F,Blumbergs PC,Raftery MJ,Gai WP

更新日期：2005-01-01 00:00:00

abstract：:The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...

journal_title：Neurotoxicity research

authors： Peana AT,Bassareo V,Acquas E

更新日期：2019-11-01 00:00:00

abstract：:Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk betwee...

journal_title：Neurotoxicity research

authors： Falcão AS,Silva RF,Vaz AR,Gomes C,Fernandes A,Barateiro A,Tiribelli C,Brites D

更新日期：2014-07-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...

journal_title：Neurotoxicity research

authors： Dikshit P,Goswami A,Mishra A,Chatterjee M,Jana NR

更新日期：2006-01-01 00:00:00

abstract：:The nucleus accumbens (Nacc) and medial prefrontal cortex (mPFC) receive dopaminergic innervation from the ventral tegmental area and are involved in learning. Male rats with 6-hydroxydopamine (6-OHDA)-induced dopaminergic and noradrenergic reductions in the Nacc or mPFC were tested for allocentric and egocentric lear...

journal_title：Neurotoxicity research

authors： Braun AA,Amos-Kroohs RM,Gutierrez A,Lundgren KH,Seroogy KB,Vorhees CV,Williams MT

更新日期：2016-08-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...

journal_title：Neurotoxicity research

authors： Hinduja S,Kraus KS,Manohar S,Salvi RJ

更新日期：2015-04-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...

journal_title：Neurotoxicity research

authors： Mester L,Szabo A,Atlasz T,Szabadfi K,Reglodi D,Kiss P,Racz B,Tamas A,Gallyas F Jr,Sumegi B,Hocsak E,Gabriel R,Kovacs K

更新日期：2009-07-01 00:00:00

abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...

journal_title：Neurotoxicity research

authors： Wang W,Dow KE,Riopelle RJ,Ross GM

更新日期：2001-10-01 00:00:00

abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

journal_title：Neurotoxicity research

authors： Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

更新日期：2019-07-01 00:00:00

abstract：:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...

journal_title：Neurotoxicity research

authors： An L,Zhang T

更新日期：2016-02-01 00:00:00

abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

journal_title：Neurotoxicity research

authors： Lv ZY,Tan CC,Yu JT,Tan L

更新日期：2017-11-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...

journal_title：Neurotoxicity research

authors： Rahbar MH,Samms-Vaughan M,Loveland KA,Ardjomand-Hessabi M,Chen Z,Bressler J,Shakespeare-Pellington S,Grove ML,Bloom K,Pearson DA,Lalor GC,Boerwinkle E

更新日期：2013-01-01 00:00:00

abstract：:Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...

journal_title：Neurotoxicity research

authors： Chun HJ,Lee Y,Kim AH,Lee J

更新日期：2016-04-01 00:00:00

abstract：:The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...

journal_title：Neurotoxicity research

authors： Goguadze N,Zhuravliova E,Morin D,Mikeladze D,Maurice T

更新日期：2019-01-01 00:00:00

abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

journal_title：Neurotoxicity research

authors： Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

更新日期：2019-05-01 00:00:00

abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...

journal_title：Neurotoxicity research

authors： Koohpeyma H,Goudarzi I,Elahdadi Salmani M,Lashkarbolouki T,Shabani M

更新日期：2019-04-01 00:00:00

abstract：:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...

journal_title：Neurotoxicity research

authors： Kulikova AA,Cheglakov IB,Kukharsky MS,Ovchinnikov RK,Kozin SA,Makarov AA

更新日期：2016-05-01 00:00:00

abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...

journal_title：Neurotoxicity research

authors： Rodriguez-Navarro AJ,Lagos M,Figueroa C,Garcia C,Recabal P,Silva P,Iglesias V,Lagos N

更新日期：2009-11-01 00:00:00

abstract：:Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...

journal_title：Neurotoxicity research

authors： Das ND,Choi MR,Jung KH,Park JH,Lee HT,Das A,Kim SH,Chai YG

更新日期：2013-02-01 00:00:00

abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...

journal_title：Neurotoxicity research

authors： Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli M

更新日期：2010-05-01 00:00:00

abstract：:Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...

journal_title：Neurotoxicity research

authors： Zhang H,Wang H,Xiao X,Zhang T

更新日期：2016-01-01 00:00:00