Melamine Alters Glutamatergic Synaptic Transmission of CA3-CA1 Synapses Presynaptically Through Autophagy Activation in the Rat Hippocampus.

abstract：:Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...

journal_title：Neurotoxicity research

authors： Songin M,Strosznajder JB,Fitał M,Kuter K,Kolasiewicz W,Nowak P,Ossowska K

更新日期：2011-01-01 00:00:00

abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...

journal_title：Neurotoxicity research

authors： Sadakierska-Chudy A,Filip M

更新日期：2015-02-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...

journal_title：Neurotoxicity research

authors： Romero AM,Palanca A,Ruiz-Soto M,Llorca J,Marín MP,Renau-Piqueras J,Berciano MT,Lafarga M

更新日期：2016-01-01 00:00:00

abstract：:Microglial activation and subsequent release of toxic pro-inflammatory factors are believed to play an important role in neuronal cell death associated with Parkinson's disease (PD). Compounds that inhibit microglia activation and suppress pro-inflammatory factor release have been reported to have neuroprotective effe...

journal_title：Neurotoxicity research

authors： Chinta SJ,Ganesan A,Reis-Rodrigues P,Lithgow GJ,Andersen JK

更新日期：2013-02-01 00:00:00

abstract：:In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...

journal_title：Neurotoxicity research

authors： Pérez-Núñez R,Barraza N,Gonzalez-Jamett A,Cárdenas AM,Barnier JV,Caviedes P

更新日期：2016-07-01 00:00:00

abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...

journal_title：Neurotoxicity research

authors： Echeverry C,Arredondo F,Martínez M,Abin-Carriquiry JA,Midiwo J,Dajas F

更新日期：2015-01-01 00:00:00

abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...

journal_title：Neurotoxicity research

authors： Beninger RJ

更新日期：2006-12-01 00:00:00

abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...

journal_title：Neurotoxicity research

authors： Endesfelder S,Weichelt U,Schiller C,Winter K,von Haefen C,Bührer C

更新日期：2018-08-01 00:00:00

abstract：:Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...

journal_title：Neurotoxicity research

authors： Lameth J,Gervais A,Colin C,Lévêque P,Jay TM,Edeline JM,Mallat M

更新日期：2017-10-01 00:00:00

abstract：:The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...

journal_title：Neurotoxicity research

authors： Ponce G,Hoenicka J,Rodríguez-Jiménez R,Gozalo A,Jimenéz M,Monasor R,Aragüés M,Rubio G,Jiménez-Arriero MA,Ramos JA,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...

journal_title：Neurotoxicity research

authors： Fisher D,Gamieldien K,Mafunda PS

更新日期：2015-07-01 00:00:00

abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...

journal_title：Neurotoxicity research

authors： Amini N,Vousooghi N,Hadjighassem M,Bakhtiyari M,Mousavi N,Safakheil H,Jafari L,Sarveazad A,Yari A,Ramezani S,Faghihi F,Joghataei MT

更新日期：2016-05-01 00:00:00

abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...

journal_title：Neurotoxicity research

authors： Zuo D,Lin L,Liu Y,Wang C,Xu J,Sun F,Li L,Li Z,Wu Y

更新日期：2016-08-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Zelek-Molik A,Antkiewicz-Michaluk L

更新日期：2018-04-01 00:00:00

abstract：:Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...

journal_title：Neurotoxicity research

authors： Iha HA,Kunisawa N,Shimizu S,Onishi M,Nomura Y,Matsubara N,Iwai C,Ogawa M,Hashimura M,Sato K,Kato M,Ohno Y

更新日期：2019-04-01 00:00:00

abstract：:Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...

journal_title：Neurotoxicity research

authors： Archer T,Beninger RJ,Palomo T,Kostrzewa RM

更新日期：2010-11-01 00:00:00

abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

journal_title：Neurotoxicity research

authors： de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

更新日期：2019-10-01 00:00:00

abstract：:The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuro...

journal_title：Neurotoxicity research

authors： Aguiar AS Jr,Lopes SC,Tristão FS,Rial D,de Oliveira G,da Cunha C,Raisman-Vozari R,Prediger RD

更新日期：2016-01-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...

journal_title：Neurotoxicity research

authors： Rodriguez-Navarro AJ,Lagos M,Figueroa C,Garcia C,Recabal P,Silva P,Iglesias V,Lagos N

更新日期：2009-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive degeneration of brain and spinal cord motor neurons. Ubiquitin-proteasome system (UPS) dysfunction and oxidative stress have been implicated in ALS pathogenesis. However, it is unknown whether the defects in thes...

journal_title：Neurotoxicity research

authors： Yang S,Zhang KY,Kariawasam R,Bax M,Fifita JA,Ooi L,Yerbury JJ,Nicholson GA,Blair IP

更新日期：2015-08-01 00:00:00

abstract：:2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...

journal_title：Neurotoxicity research

authors： Liu X,Ding D,Chen GD,Li L,Jiang H,Salvi R

更新日期：2020-10-01 00:00:00

abstract：:Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures...

journal_title：Neurotoxicity research

authors： Lau FC,Frank TC,Nahm SS,Stoica G,Abbott LC

更新日期：2004-01-01 00:00:00

abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...

journal_title：Neurotoxicity research

authors： Li Y,Ding D,Jiang H,Fu Y,Salvi R

更新日期：2011-11-01 00:00:00

abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...

journal_title：Neurotoxicity research

authors： Lipska BK,Weinberger DR

更新日期：2002-08-01 00:00:00

abstract：:We present for discussion a possible molecular mechanism explaining the formation of reactive oxygen species involved in the neurodegenerative process of dopaminergic system in Parkinson's disease. This new hypothesis involves one-electron reduction of aminochrome to o-semiquinone radical, which seems to be the reacti...

journal_title：Neurotoxicity research

authors： Segura-Aguilar J,Metodiewa D,Baez S

更新日期：2001-04-01 00:00:00

abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...

journal_title：Neurotoxicity research

authors： Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar J

更新日期：2004-01-01 00:00:00