Abstract：
:Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects on myelin-related gene expression have not been sufficiently explored. In the present study, we used the Affymetrix Mouse Gene 2.0 ST Array to analyze the changes in gene expression profiles. Comparative gene expression profiling in age-matched C57BL/6 mice administered with 0.2% CPZ and with normal diet, revealed that the expression of 1655 genes was significantly changed in CPZ-fed mice with a fold change ≥ 1.5. Our results demonstrated that CPZ-induced demyelination induces apparent alterations in the expression of most of the myelin-related genes, including the 6 key genes MBP, MAG, and MOG and GFAP, CXCR4, and NgR, which were observed to be downregulated and upregulated, respectively, suggesting that the differences in gene expression in vivo could serve as potential therapeutic targets for remyelination.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Han SR,Kang YH,Yoo SM,Lee MS,Lee SHdoi
10.1007/s12640-019-00154-3subject
Has Abstractpub_date
2020-03-01 00:00:00pages
732-742issue
3eissn
1029-8428issn
1476-3524pii
10.1007/s12640-019-00154-3journal_volume
37pub_type
杂志文章abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9476-x
更新日期：2014-10-01 00:00:00
abstract：:2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00252-7
更新日期：2020-10-01 00:00:00
abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9520-5
更新日期：2015-07-01 00:00:00
abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9403-6
更新日期：2013-10-01 00:00:00
abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9244-0
更新日期：2011-11-01 00:00:00
abstract：:We present for discussion a possible molecular mechanism explaining the formation of reactive oxygen species involved in the neurodegenerative process of dopaminergic system in Parkinson's disease. This new hypothesis involves one-electron reduction of aminochrome to o-semiquinone radical, which seems to be the reacti...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033188
更新日期：2001-04-01 00:00:00
abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9235-6
更新日期：2011-08-01 00:00:00
abstract：:Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in hum...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9067-4
更新日期：2010-01-01 00:00:00
abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9321-z
更新日期：2013-01-01 00:00:00
abstract：:Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9800-3
更新日期：2018-02-01 00:00:00
abstract：:1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9228-5
更新日期：2011-08-01 00:00:00
abstract：:L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9686-5
更新日期：2017-04-01 00:00:00
abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9028-y
更新日期：2009-04-01 00:00:00
abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9018-0
更新日期：2009-02-01 00:00:00
abstract：:Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9312-0
更新日期：2012-11-01 00:00:00
abstract：:Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9180-4
更新日期：2011-04-01 00:00:00
abstract：:Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9369-9
更新日期：2013-08-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033367
更新日期：2008-01-01 00:00:00
abstract：:Maillard reactions have been explored by food chemists for many years. It is only recently that the advanced glycation end products (AGEs), the end products of the Maillard reaction, have been detected in a wide variety of diseases such as diabetes, atherosclerosis, cataractogenesis, Parkinson disease and Alzheimer di...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/1029840290007321
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00124-9
更新日期：2020-03-01 00:00:00
abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9451-y
更新日期：2014-07-01 00:00:00
abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033288
更新日期：2000-02-01 00:00:00
abstract：:Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00021-1
更新日期：2019-11-01 00:00:00
abstract：:Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9554-8
更新日期：2016-01-01 00:00:00
abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...
journal_title：Neurotoxicity research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/BF03033223
更新日期：2004-01-01 00:00:00
abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...
journal_title：Neurotoxicity research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s12640-009-9092-3
更新日期：2009-11-01 00:00:00
abstract：:Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00321-x
更新日期：2021-01-05 00:00:00
abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290015908
更新日期：2002-03-01 00:00:00
