Exercise Improves Cognitive Impairment and Dopamine Metabolism in MPTP-Treated Mice.

abstract：:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...

journal_title：Neurotoxicity research

authors： An L,Zhang T

更新日期：2016-02-01 00:00:00

abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Zelek-Molik A,Antkiewicz-Michaluk L

更新日期：2018-04-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Zelek-Molik A,Nalepa I,Antkiewicz-Michaluk L

更新日期：2016-04-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...

journal_title：Neurotoxicity research

authors： Milosevic J,Adler I,Manaenko A,Schwarz SC,Walkinshaw G,Arend M,Flippin LA,Storch A,Schwarz J

更新日期：2009-05-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...

journal_title：Neurotoxicity research

authors： Mester L,Szabo A,Atlasz T,Szabadfi K,Reglodi D,Kiss P,Racz B,Tamas A,Gallyas F Jr,Sumegi B,Hocsak E,Gabriel R,Kovacs K

更新日期：2009-07-01 00:00:00

abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

journal_title：Neurotoxicity research

authors： Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

更新日期：2020-08-01 00:00:00

abstract：:Aging plays a significant role in the progression of vascular diseases and vascular dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory signals may cause vascular permeability and endothelial leakage. Pro-inflammatory molecules have a significant effect on smooth muscle cells (SM...

journal_title：Neurotoxicity research

authors： Uddin MS,Kabir MT,Jakaria M,Mamun AA,Niaz K,Amran MS,Barreto GE,Ashraf GM

更新日期：2019-10-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...

journal_title：Neurotoxicity research

authors： K C S,Kakoty V,Marathe S,Chitkara D,Taliyan R

更新日期：2020-07-18 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

journal_title：Neurotoxicity research

authors： Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

更新日期：2020-03-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...

journal_title：Neurotoxicity research

authors： Ślusarczyk J,Piotrowski M,Szczepanowicz K,Regulska M,Leśkiewicz M,Warszyński P,Budziszewska B,Lasoń W,Basta-Kaim A

更新日期：2016-11-01 00:00:00

abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...

journal_title：Neurotoxicity research

authors： Rahbar MH,Samms-Vaughan M,Loveland KA,Ardjomand-Hessabi M,Chen Z,Bressler J,Shakespeare-Pellington S,Grove ML,Bloom K,Pearson DA,Lalor GC,Boerwinkle E

更新日期：2013-01-01 00:00:00

abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...

journal_title：Neurotoxicity research

authors： Zuo D,Lin L,Liu Y,Wang C,Xu J,Sun F,Li L,Li Z,Wu Y

更新日期：2016-08-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotrans...

journal_title：Neurotoxicity research

authors： Kaindl AM,Ikonomidou C

更新日期：2007-04-01 00:00:00

abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...

journal_title：Neurotoxicity research

authors： Li Y,Ding D,Jiang H,Fu Y,Salvi R

更新日期：2011-11-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...

journal_title：Neurotoxicity research

authors： Thakur V,Jamwal S,Kumar M,Rahi V,Kumar P

更新日期：2020-08-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...

journal_title：Neurotoxicity research

authors： Amini N,Vousooghi N,Hadjighassem M,Bakhtiyari M,Mousavi N,Safakheil H,Jafari L,Sarveazad A,Yari A,Ramezani S,Faghihi F,Joghataei MT

更新日期：2016-05-01 00:00:00

abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

journal_title：Neurotoxicity research

authors： Lv ZY,Tan CC,Yu JT,Tan L

更新日期：2017-11-01 00:00:00

abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...

journal_title：Neurotoxicity research

authors： Villani L,Beraudi A,Giuliani A,Poli A

更新日期：2001-07-01 00:00:00

abstract：:Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...

journal_title：Neurotoxicity research

authors： Das ND,Choi MR,Jung KH,Park JH,Lee HT,Das A,Kim SH,Chai YG

更新日期：2013-02-01 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...

journal_title：Neurotoxicity research

authors： Cecatto C,Amaral AU,Leipnitz G,Castilho RF,Wajner M

更新日期：2014-08-01 00:00:00

abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...

journal_title：Neurotoxicity research

authors： Wang B,Zhao J,Yu M,Meng X,Cui X,Zhao Y,Zhu Y,Xing W,Guan Y

更新日期：2014-07-01 00:00:00

abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Segura-Aguilar J

更新日期：2003-01-01 00:00:00

abstract：:Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...

journal_title：Neurotoxicity research

authors： Fürstenau CR,de Souza ICC,de Oliveira MR

更新日期：2019-10-01 00:00:00