Abstract:
:Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk between neurons and astrocytes may protect or aggravate neurotoxicity by unconjugated bilirubin (UCB). In a previous work we have shown that bidirectional signaling during astrocyte-neuron recognition attenuates neuronal damage by UCB. Here, we investigated whether the establishment of neuron-astrocyte homeostasis prior to cell exposure to UCB was instead associated with a lower resistance of neurons to UCB toxicity, and if the pro-survival properties of GUDCA were replicated in that experimental model. We have introduced a 24 h adaptation period for neuron-glia communication prior to the 48 h treatment with UCB. In such conditions, UCB induced glial activation, which aggravated neuronal damage, comprising increased apoptosis,cell demise and neuritic atrophy, which were completely prevented in the presence of GUDCA. Neuronal multidrug resistance-associated protein 1 expression and tumor necrosis factor-a secretion, although unchanged by UCB, increased in the presence of astrocytes. The rise in S100B and nitric oxide in the co-cultures medium may have contributed to UCB neurotoxicity. Since the levels of these diffusible molecules did not change by GUDCA we may assume that they are not directly involved in its beneficial effects. Data indicate that astrocytes, in an indirect neuron-astrocyte co-culture model and after homeostatic setting regulation of the system, are critically influencing neurodegeneration by UCB, and support GUDCA for the prevention of BIND.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Falcão AS,Silva RF,Vaz AR,Gomes C,Fernandes A,Barateiro A,Tiribelli C,Brites Ddoi
10.1007/s12640-013-9427-ysubject
Has Abstractpub_date
2014-07-01 00:00:00pages
1-15issue
1eissn
1029-8428issn
1476-3524journal_volume
26pub_type
杂志文章abstract::Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9824-8
更新日期:2018-04-01 00:00:00
abstract::This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9235-6
更新日期:2011-08-01 00:00:00
abstract::The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033311
更新日期:2004-01-01 00:00:00
abstract::Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9125-y
更新日期:2010-05-01 00:00:00
abstract::The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033183
更新日期:2004-01-01 00:00:00
abstract::Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033151
更新日期:2003-01-01 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9049-6
更新日期:2009-07-01 00:00:00
abstract::Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-010-9163-5
更新日期:2010-11-01 00:00:00
abstract::Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9369-9
更新日期:2013-08-01 00:00:00
abstract::High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9018-0
更新日期:2009-02-01 00:00:00
abstract::The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9495-7
更新日期:2015-02-01 00:00:00
abstract::Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery w...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9827-5
更新日期:2018-05-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive degeneration of brain and spinal cord motor neurons. Ubiquitin-proteasome system (UPS) dysfunction and oxidative stress have been implicated in ALS pathogenesis. However, it is unknown whether the defects in thes...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9532-1
更新日期:2015-08-01 00:00:00
abstract::Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of B...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9526-z
更新日期:2015-05-01 00:00:00
abstract::During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033229
更新日期:2001-01-01 00:00:00
abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00154-3
更新日期:2020-03-01 00:00:00
abstract::Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00321-x
更新日期:2021-01-05 00:00:00
abstract::In the slowly progressive neurodegenerative disorders like Parkinson's disease and Alzheimer's disease very different neuronal populations undergo degenerative processes, although the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkins...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033793
更新日期:2000-01-01 00:00:00
abstract::Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9542-z
更新日期:2015-10-01 00:00:00
abstract::The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033824
更新日期:2005-10-01 00:00:00
abstract::To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033559
更新日期:2008-04-01 00:00:00
abstract::Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290015908
更新日期:2002-03-01 00:00:00
abstract::Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00091-1
更新日期:2019-10-01 00:00:00
abstract::Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9754-5
更新日期:2017-10-01 00:00:00
abstract::Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9476-x
更新日期:2014-10-01 00:00:00
abstract::In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/1029842021000022089
更新日期:2002-08-01 00:00:00
abstract::The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290007592
更新日期:2002-02-01 00:00:00
abstract::Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00118-7
更新日期:2020-02-01 00:00:00
abstract::Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00017-x
更新日期:2019-07-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9556-6
更新日期:2016-04-01 00:00:00