Abstract:
:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxicity. MDMA (4 x 20 mg/kg) was acutely administered to mice alone or in combination with caffeine (10 mg/kg). CD11b and GFAP immunoreactivity were evaluated as markers of microglia and astroglia activation in the substantia nigra pars-compacta (SNc) and striatum. MDMA was associated with significantly higher CD11b and GFAP immunoreactivity in striatum, whereas only CD11b was significantly higher than vehicle in SNc. Caffeine potentiated the increase in CD11b and GFAP in the striatum but not in the SNc of MDMA-treated mice. The abuse of MDMA is a growing worldwide problem; the results of this study suggest that combination of MDMA plus caffeine by increasing glial activation might have harmful health consequences.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli Mdoi
10.1007/s12640-009-9125-ysubject
Has Abstractpub_date
2010-05-01 00:00:00pages
435-9issue
4eissn
1029-8428issn
1476-3524journal_volume
17pub_type
杂志文章abstract::Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...
journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9043-z
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9556-6
更新日期:2016-04-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033778
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 历史文章,杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9611-y
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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