Abstract:
:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin coordination complexes with the metal ions Cu+2, Zn+2, Ni+2, Co+2, and Fe+2 were synthesized to investigate their potential use against Alzheimer's disease, by evaluating the inhibition of acetylcholinesterase in vitro and in silico, as well as the antioxidant activity, toxicity, and anxiolytic action in the zebrafish (Danio rerio) model. The organic complexes were characterized by UV-Vis and FT-IR. The spectral information suggested that coordination of metals occurs with the carbonyl group and OH linked to the C-3 carbon of quercetin. The quercetin-Fe (QFe) complex presented the best antioxidant and antiacetylcholinesterase actions, and these results were confirmed by molecular docking. In the toxicity and locomotor evaluation, the quercetin molecules and the synthesized complexes, mainly QCu and QZn derivatives, showed the highest degree of inhibition of the fish's locomotor activity, suggesting a possible anxiolytic action. Then, quercetin complexes with metals, mainly with Fe+2, represent valuable compounds and deserve more investigation as promising agents against Alzheimer's disease.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
da Silva WMB,de Oliveira Pinheiro S,Alves DR,de Menezes JESA,Magalhães FEA,Silva FCO,Silva J,Marinho ES,de Morais SMdoi
10.1007/s12640-019-00142-7subject
Has Abstractpub_date
2020-04-01 00:00:00pages
893-903issue
4eissn
1029-8428issn
1476-3524pii
10.1007/s12640-019-00142-7journal_volume
37pub_type
杂志文章abstract::Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...
journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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doi:10.1007/s12640-013-9390-7
更新日期:2013-11-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/BF03033386
更新日期:2003-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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doi:10.1007/s12640-020-00258-1
更新日期:2020-07-18 00:00:00
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更新日期:2007-12-01 00:00:00
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033301
更新日期:2004-01-01 00:00:00
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