Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration.

Abstract:

:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic administration of 3-NP using an osmotic mini pump, were examined in the Lewis rats. Lewis rats were treated with 3-NP or saline for 2 days and behavior was tested daily for a 15 day period. Animals receiving 3-NP displayed significantly less spontaneous activity than animals in the saline group. 3-NP treated animals also weighed significantly less when compared to saline treated animals. These results demonstrate that even though there were no significant alterations in overt anatomical pathology, even short-term exposure to 3-NP produced significant effects. This short-term administration may present a potential paradigm for examination of sub-threshold neurotoxicity.

journal_name

Neurotox Res

journal_title

Neurotoxicity research

authors

Newcomb JD,Brown WD,Rodriguez AI,Garbuzova-Davis S,Saporta S,Sanberg PR,Willing AE

doi

10.1007/BF03033979

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

259-66

issue

3-4

eissn

1029-8428

issn

1476-3524

journal_volume

8

pub_type

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