Abstract：
:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of 316 patients with ischemic stroke. The end point was stroke recurrence after 1-year follow-up. We used logistic regression model to assess the relationship between copeptin levels and risk recurrent stroke. Logistic regression analysis considering traditional risk factors showed a relationship between serum copeptin levels and moderate-to-high clinical severity when serum copeptin was used as a continuous variable (OR, 1.05; 95% CI, 1.03-1.09). In the follow-up, 54 patients (17.1%) had a stroke recurrence. The stroke recurrence events distribution across the copeptin quartiles ranged between 5.1% (first quartile) to 23.1% (fourth quartile). In multivariate models comparing the third (OR = 2.78; 95% CI 1.85-3.53) and fourth quartiles (OR = 4.00; 95% CI 2.86-6.50) against the first quartile of the copeptin, levels of copeptin were associated with stroke recurrence events. A higher serum copeptin level is a predictor of both severity at admission and stroke recurrence at 1-year in stroke patients.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Tang WZ,Wang XB,Li HT,Dong M,Ji Xdoi
10.1007/s12640-017-9754-5subject
Has Abstractpub_date
2017-10-01 00:00:00pages
420-425issue
3eissn
1029-8428issn
1476-3524pii
10.1007/s12640-017-9754-5journal_volume
32pub_type
杂志文章abstract：:Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00161-9
更新日期：2020-04-01 00:00:00
abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-017-9765-2
更新日期：2017-11-01 00:00:00
abstract：:Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00118-7
更新日期：2020-02-01 00:00:00
abstract：:One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12640-019-00153-4
更新日期：2020-03-01 00:00:00
abstract：:Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9251-1
更新日期：2012-02-01 00:00:00
abstract：:Impulse control disorders (ICDs) comprise a wide spectrum of abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian treatment. Some ICDs share several essential features with substance use disorders. In this work, we have studied the addiction-related gene ankyrin repe...
journal_title：Neurotoxicity research
pub_type： 杂志文章,多中心研究
doi：10.1007/s12640-014-9504-x
更新日期：2015-04-01 00:00:00
abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9979-y
更新日期：2019-04-01 00:00:00
abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9503-y
更新日期：2015-04-01 00:00:00
abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9483-y
更新日期：2015-01-01 00:00:00
abstract：:Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00054-6
更新日期：2019-08-01 00:00:00
abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9063-8
更新日期：2009-08-01 00:00:00
abstract：:Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9153-7
更新日期：2011-01-01 00:00:00
abstract：:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9603-y
更新日期：2016-05-01 00:00:00
abstract：:The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9838-2
更新日期：2019-01-01 00:00:00
abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9421-4
更新日期：2014-02-01 00:00:00
abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...
journal_title：Neurotoxicity research
pub_type： 评论,杂志文章
doi：10.1007/s12640-019-00100-3
更新日期：2020-01-01 00:00:00
abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9508-6
更新日期：2015-02-01 00:00:00
abstract：:Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9081-6
更新日期：2009-11-01 00:00:00
abstract：:The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induct...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9333-8
更新日期：2013-01-01 00:00:00
abstract：:Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9290-7
更新日期：2012-05-01 00:00:00
abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033183
更新日期：2004-01-01 00:00:00
abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9403-6
更新日期：2013-10-01 00:00:00
abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00055-5
更新日期：2019-11-01 00:00:00
abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033205
更新日期：2001-10-01 00:00:00
abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033559
更新日期：2008-04-01 00:00:00
abstract：:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00142-7
更新日期：2020-04-01 00:00:00
abstract：:During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033229
更新日期：2001-01-01 00:00:00
abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9476-x
更新日期：2014-10-01 00:00:00
abstract：:Neuronal cell death caused by pathophysiological over-activation of glutamate receptors and the subsequent CaII overloading, has been implicated in neurodegeneration after stroke, cerebral trauma and epileptic seizures. Recent findings suggest that certain progesterone metabolites (neurosteroids) such as allopregnanol...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033504
更新日期：2008-05-01 00:00:00
abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033284
更新日期：2004-01-01 00:00:00
