Abstract:
:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinical, longitudinal study to investigate the effect of chronic nicotine exposure on mGluR5 with the novel radiotracer [18F]PSS232 using PET. Twelve male dark Agouti rats at the age of 6 weeks were assigned randomly to three groups. From day 0 to day 250 the groups received 0 mg/L, 4 mg/L, or 8 mg/L nicotine solution in the drinking water. From day 250 to 320 all groups received nicotine-free drinking water. PET scans with [18F]PSS232 were performed in all animals on days 0, 250, and 320. To assess locomotion, seven tests in square open field arenas were carried out 72 days after the last PET scan. During the first four tests, rats received 0 mg/L nicotine and for the last three tests 4 mg/L nicotine in the drinking water. After 250 days of nicotine consumption [18F]PSS232 binding was reduced in the striatum, hippocampus, thalamus, and midbrain. At day 320, after nicotine withdrawal, [18F]PSS232 binding increased. These effects were more pronounced in the 4 mg/L nicotine group. Chronic administration of nicotine through the drinking water reduced exploratory behaviour. This preliminary longitudinal PET study demonstrates that chronic nicotine administration alters behaviour and mGluR5 availability. Chronic nicotine administration leads to decreased [18F]PSS232 binding which normalizes after prolonged nicotine withdrawal.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler Gdoi
10.1007/s12640-019-00055-5subject
Has Abstractpub_date
2019-11-01 00:00:00pages
806-816issue
4eissn
1029-8428issn
1476-3524pii
10.1007/s12640-019-00055-5journal_volume
36pub_type
杂志文章abstract::Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9896-0
更新日期:2018-11-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9754-5
更新日期:2017-10-01 00:00:00
abstract::Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033205
更新日期:2001-10-01 00:00:00
abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00154-3
更新日期:2020-03-01 00:00:00
abstract::Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00294-x
更新日期:2020-10-06 00:00:00
abstract::Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9125-y
更新日期:2010-05-01 00:00:00
abstract::Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9250-2
更新日期:2011-11-01 00:00:00
abstract::One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12640-019-00153-4
更新日期:2020-03-01 00:00:00
abstract::The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-019-00051-9
更新日期:2019-11-01 00:00:00
abstract::Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033913
更新日期:2007-10-01 00:00:00
abstract::Impulse control disorders (ICDs) comprise a wide spectrum of abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian treatment. Some ICDs share several essential features with substance use disorders. In this work, we have studied the addiction-related gene ankyrin repe...
journal_title:Neurotoxicity research
pub_type: 杂志文章,多中心研究
doi:10.1007/s12640-014-9504-x
更新日期:2015-04-01 00:00:00
abstract::The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033824
更新日期:2005-10-01 00:00:00
abstract::Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...
journal_title:Neurotoxicity research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s12640-009-9092-3
更新日期:2009-11-01 00:00:00
abstract::The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033284
更新日期:2004-01-01 00:00:00
abstract::The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033804
更新日期:2008-10-01 00:00:00
abstract::Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9369-9
更新日期:2013-08-01 00:00:00
abstract::Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033778
更新日期:2005-01-01 00:00:00
abstract::Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9346-3
更新日期:2013-02-01 00:00:00
abstract::2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00252-7
更新日期:2020-10-01 00:00:00
abstract::Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290015908
更新日期:2002-03-01 00:00:00
abstract::C57/BL6 mice were administered either 7.5 mg Fe (II)/ kg or vehicle (saline) postnatally on Days 10-12 after birth. From 64 days of age onwards for 24 days, groups of mice were administered either haloperidol (0.25 or 1 or 2 mg/kg, s.c.) or vehicle (Tween-80). Twenty-four hours after the final injection of either neur...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033321
更新日期:2006-06-01 00:00:00
abstract::Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033334
更新日期:2006-08-01 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9905-3
更新日期:2018-10-01 00:00:00
abstract::Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00101-2
更新日期:2020-01-01 00:00:00
abstract::Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9312-0
更新日期:2012-11-01 00:00:00
abstract::Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9460-5
更新日期:2014-08-01 00:00:00
abstract::Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9180-4
更新日期:2011-04-01 00:00:00
abstract::The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9508-6
更新日期:2015-02-01 00:00:00
abstract::Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9153-7
更新日期:2011-01-01 00:00:00
abstract::There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9468-x
更新日期:2014-10-01 00:00:00