The addiction-related gene ANKK1 in Parkinsonian patients with impulse control disorder.

abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...

journal_title：Neurotoxicity research

authors： Zuo D,Lin L,Liu Y,Wang C,Xu J,Sun F,Li L,Li Z,Wu Y

更新日期：2016-08-01 00:00:00

abstract：:Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...

journal_title：Neurotoxicity research

authors： Kikuchi-Utsumi K,Ishizaka M,Matsumura N,Watabe M,Aoyama K,Sasakawa N,Nakaki T

更新日期：2013-08-01 00:00:00

abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

journal_title：Neurotoxicity research

authors： Lv ZY,Tan CC,Yu JT,Tan L

更新日期：2017-11-01 00:00:00

abstract：:Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...

journal_title：Neurotoxicity research

authors： Han SR,Kang YH,Yoo SM,Lee MS,Lee SH

更新日期：2020-03-01 00:00:00

abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...

journal_title：Neurotoxicity research

authors： Blackwood DH,Pickard BJ,Thomson PA,Evans KL,Porteous DJ,Muir WJ

更新日期：2007-01-01 00:00:00

abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...

journal_title：Neurotoxicity research

authors： Hempstead BL

更新日期：2009-10-01 00:00:00

abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...

journal_title：Neurotoxicity research

authors： Avila J,Pérez M,Lim F,Gómez-Ramos A,Hernández F,Lucas JJ

更新日期：2004-01-01 00:00:00

abstract：:Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery w...

journal_title：Neurotoxicity research

authors： Zhou X,Lu D,Li WD,Chen XH,Yang XY,Chen X,Zhou ZB,Ye JH,Feng X

更新日期：2018-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...

journal_title：Neurotoxicity research

authors： Kuszczyk MA,Sadowski MJ,Antkiewicz-Michaluk L,Lazarewicz JW

更新日期：2014-05-01 00:00:00

abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...

journal_title：Neurotoxicity research

authors： Bercker S,Bert B,Bittigau P,Felderhoff-Müser U,Bührer C,Ikonomidou C,Weise M,Kaisers UX,Kerner T

更新日期：2009-08-01 00:00:00

abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...

journal_title：Neurotoxicity research

authors： Endesfelder S,Weichelt U,Schiller C,Winter K,von Haefen C,Bührer C

更新日期：2018-08-01 00:00:00

abstract：:Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in hum...

journal_title：Neurotoxicity research

authors： Adamo AM,Zago MP,Mackenzie GG,Aimo L,Keen CL,Keenan A,Oteiza PI

更新日期：2010-01-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...

journal_title：Neurotoxicity research

authors： Copeland RL Jr,Das JR,Kanaan YM,Taylor RE,Tizabi Y

更新日期：2007-07-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:C57/BL6 mice were administered either 7.5 mg Fe (II)/ kg or vehicle (saline) postnatally on Days 10-12 after birth. From 64 days of age onwards for 24 days, groups of mice were administered either haloperidol (0.25 or 1 or 2 mg/kg, s.c.) or vehicle (Tween-80). Twenty-four hours after the final injection of either neur...

journal_title：Neurotoxicity research

authors： Fredriksson A,Archer T

更新日期：2006-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...

journal_title：Neurotoxicity research

authors： K C S,Kakoty V,Marathe S,Chitkara D,Taliyan R

更新日期：2020-07-18 00:00:00

abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...

journal_title：Neurotoxicity research

authors： Fernandes CG,Pierozan P,Soares GM,Ferreira F,Zanatta Â,Amaral AU,Borges CG,Wajner M,Pessoa-Pureur R

更新日期：2015-10-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

journal_title：Neurotoxicity research

authors： Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

更新日期：2020-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...

journal_title：Neurotoxicity research

authors： Hemendinger RA,Armstrong EJ 3rd,Persinski R,Todd J,Mougeot JL,Volvovitz F,Rosenfeld J

更新日期：2008-01-01 00:00:00

abstract：:Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

journal_title：Neurotoxicity research

authors： Wojcieszak J,Kuczyńska K,Zawilska JB

更新日期：2021-01-11 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

journal_title：Neurotoxicity research

authors： Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

更新日期：2020-03-01 00:00:00

abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

journal_title：Neurotoxicity research

authors： Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

更新日期：2020-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...

journal_title：Neurotoxicity research

authors： Tang XQ,Fan LL,Li YJ,Shen XT,Zhuan YY,He JQ,Xu JH,Hu B,Li YJ

更新日期：2011-04-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...

journal_title：Neurotoxicity research

authors： Kouri G,Theophilidis G

更新日期：2002-02-01 00:00:00

abstract：:During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...

journal_title：Neurotoxicity research

authors： Eriksson P,Ankarberg E,Viberg H,Fredriksson A

更新日期：2001-01-01 00:00:00

abstract：:The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...

journal_title：Neurotoxicity research

authors： Lau WK,Mak JC,Chan KH,Law AC

更新日期：2012-08-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...

journal_title：Neurotoxicity research

authors： Ślusarczyk J,Piotrowski M,Szczepanowicz K,Regulska M,Leśkiewicz M,Warszyński P,Budziszewska B,Lasoń W,Basta-Kaim A

更新日期：2016-11-01 00:00:00