Abstract：
:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was designed to evaluate the Hcy effects on neonatal rat cerebellum and cerebellar oxidative stress. We also evaluated the folic acid effects on biochemical alterations elicited by hyperhomocysteinemia (hHcy) in the cerebellum. Group I received normal saline, group II received Hcy subcutaneously twice a day at 8-h intervals (0.3-0.6 μmol/g body weight), group III received Hcy + folic acid (0.011 μmol/g body weight), and group IV received folic acid on postnatal day (PD) 4 until 25. On day 25, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in the cerebellum and motor cortex were assayed. Malondialdehyde (MDA) levels were also evaluated as a marker of lipid peroxidation. Rotarod and locomotor activity tests were performed in PD 25-27. Our results indicated that administration of Hcy increased plasma, cortical, and cerebellar total Hcy levels; reduced GPx activity; and induced lipid peroxidation in the cerebellum. Hcy impaired performance on the rotarod in rats. However, treatment with folic acid significantly attenuated motor coordination impairment, GPx activity reduction, the lipid peroxidation process, and significantly reduced plasma total Hcy levels. Histological analysis indicated that Hcy could decrease Purkinje cell count and folic acid prevented this toxic effect. We conclude that Hcy can induce neurotoxicity and folic acid has neuroprotective effects against cerebellar Hcy toxicity.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Koohpeyma H,Goudarzi I,Elahdadi Salmani M,Lashkarbolouki T,Shabani Mdoi
10.1007/s12640-018-9979-ysubject
Has Abstractpub_date
2019-04-01 00:00:00pages
724-738issue
3eissn
1029-8428issn
1476-3524pii
10.1007/s12640-018-9979-yjournal_volume
35pub_type
杂志文章abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9244-0
更新日期：2011-11-01 00:00:00
abstract：:L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9686-5
更新日期：2017-04-01 00:00:00
abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033559
更新日期：2008-04-01 00:00:00
abstract：:Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9570-8
更新日期：2016-01-01 00:00:00
abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00294-x
更新日期：2020-10-06 00:00:00
abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033484
更新日期：2007-01-01 00:00:00
abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033906
更新日期：2007-12-01 00:00:00
abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9028-y
更新日期：2009-04-01 00:00:00
abstract：:Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk betwee...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9427-y
更新日期：2014-07-01 00:00:00
abstract：:Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-0007-7
更新日期：2019-04-01 00:00:00
abstract：:In the slowly progressive neurodegenerative disorders like Parkinson's disease and Alzheimer's disease very different neuronal populations undergo degenerative processes, although the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkins...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033793
更新日期：2000-01-01 00:00:00
abstract：:In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9613-9
更新日期：2016-07-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033804
更新日期：2008-10-01 00:00:00
abstract：:Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9896-0
更新日期：2018-11-01 00:00:00
abstract：:Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9740-y
更新日期：2018-01-01 00:00:00
abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9542-z
更新日期：2015-10-01 00:00:00
abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...
journal_title：Neurotoxicity research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/BF03033223
更新日期：2004-01-01 00:00:00
abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9520-5
更新日期：2015-07-01 00:00:00
abstract：:Sepsis-associated encephalopathy causes brain dysfunction that can result in cognitive impairments in sepsis survivor patients. In previous work, we showed that simvastatin attenuated oxidative stress in brain structures related to memory in septic rats. However, there is still a need to evaluate the long-term impact ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00222-z
更新日期：2020-12-01 00:00:00
abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033979
更新日期：2005-11-01 00:00:00
abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033454
更新日期：2004-01-01 00:00:00
abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9503-y
更新日期：2015-04-01 00:00:00
abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9599-3
更新日期：2016-05-01 00:00:00
abstract：:The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...
journal_title：Neurotoxicity research
pub_type： 已发布勘误
doi：10.1007/s12640-018-9982-3
更新日期：2019-05-01 00:00:00
abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033861
更新日期：2008-12-01 00:00:00
abstract：:In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9497-5
更新日期：2015-01-01 00:00:00
abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...
journal_title：Neurotoxicity research
pub_type： 评论,杂志文章
doi：10.1007/s12640-019-00100-3
更新日期：2020-01-01 00:00:00
abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00044-8
更新日期：2019-10-01 00:00:00
