Abstract：
:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a strategy for promoting cisplatin-induced ototoxicity by coadministration of furosemide a loop diuretic. A dose-response study identified 200 mg/kg of furosemide as the optimal dose for disrupting the stria vascularis and opening the blood-ear barrier. Our analysis of stria pathology indicated that the optimal period for administering cisplatin was 1 h after furosemide treatment. Combined treatment with 0.5 mg/kg of cisplatin and 200 mg/kg furosemide resulted in only moderate loss of outer hair cells in the basal 20% of the cochlea, only mild threshold shifts and minimal loss of distortion product otoacoustic emission (DPOAE). In contrast, 1 mg/kg of cisplatin plus 200 mg/kg of furosemide resulted in a permanent 40-50 dB elevation of auditory brainstem response thresholds, almost complete elimination of DPOAE, and nearly total loss of outer hair cells. The widespread outer hair cell lesions that develop in mice treated with cisplatin plus furosemide could serve as extremely useful murine model for investigating techniques for regenerating outer hair cells, studying the mechanisms of cisplatin and furosemide ototoxicity and assessing the perceptual and electrophysiological consequences of outer hair cell loss on central auditory plasticity.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Li Y,Ding D,Jiang H,Fu Y,Salvi Rdoi
10.1007/s12640-011-9244-0subject
Has Abstractpub_date
2011-11-01 00:00:00pages
307-19issue
4eissn
1029-8428issn
1476-3524journal_volume
20pub_type
杂志文章abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00163-7
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abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033778
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00161-9
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9390-7
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033906
更新日期：2007-12-01 00:00:00
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journal_title：Neurotoxicity research
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更新日期：2012-07-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neurotoxicity research
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doi：10.1007/s12640-012-9316-9
更新日期：2012-08-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9740-y
更新日期：2018-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9616-6
更新日期：2016-08-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9570-8
更新日期：2016-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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doi：10.1007/s12640-021-00329-x
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9081-6
更新日期：2009-11-01 00:00:00
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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更新日期：2007-04-01 00:00:00
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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doi：10.1007/s12640-016-9613-9
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journal_title：Neurotoxicity research
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doi：10.1007/s12640-019-0007-7
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033804
更新日期：2008-10-01 00:00:00
abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title：Neurotoxicity research
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