Abstract:
:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPTP administration, are consistent with classic changes observed in the programmed cell death. The DNA strand breaks that characterize apoptotic death are in situ detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Villani L,Beraudi A,Giuliani A,Poli Adoi
10.1007/BF03033264keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
255-7issue
3eissn
1029-8428issn
1476-3524journal_volume
3pub_type
杂志文章abstract::Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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更新日期:2012-08-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033288
更新日期:2000-02-01 00:00:00
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journal_title:Neurotoxicity research
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abstract::L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...
journal_title:Neurotoxicity research
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更新日期:2017-04-01 00:00:00