Abstract:
:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidative stress in 6-hydroxydopamine-treated rats suggesting that this effect may account for neuroprotective properties of drugs. In the present study, rats were injected with reserpine (10 mg/kg sc) and 18 h later the effect of the adenosine A(2A) receptor antagonists 8-(3-chlorostyryl)caffeine (CSC) and 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol (ZM 241385) on extracellular DA, glutamate and hydroxyl radical formation was studied in the rat striatum using in vivo microdialysis. By disrupting VMAT2 function, reserpine depleted DA stores, and increased glutamate and hydroxyl radical levels in the rat striatum. CSC (1 mg/kg) but not ZM 241385 (3 mg/kg) increased extracellular DA level and production of hydroxyl radical in reserpinised rats. Both antagonists decreased the reserpine-induced increase in extracellular glutamate. L-3,4-Dihydroxyphenylalanine (L-DOPA) (25 mg/kg) significantly enhanced extracellular DA, had no effect on reserpine-induced hydroxyl radical production and decreased extracellular glutamate concentration. CSC but not ZM 241385 given jointly with L-DOPA increased the effect of L-DOPA on extracellular DA and augmented the reserpine-induced hydroxyl radical production. CSC and ZM 241385 did not influence extracellular glutamate level, which was decreased by L-DOPA. It seems that by decreasing the MAO-dependent DA metabolism rate, CSC raised cytosolic DA and by DA autoxidation, it induced hydroxyl radical overproduction. Thus, the methylxanthine A(2A) receptor antagonists bearing properties of MAO-B inhibitor, like CSC, may cause a risk of oxidative stress resulting from dysfunctional DA storage mechanism in early PD.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Gołembiowska K,Dziubina Adoi
10.1007/s12640-012-9316-9subject
Has Abstractpub_date
2012-08-01 00:00:00pages
150-7issue
2eissn
1029-8428issn
1476-3524journal_volume
22pub_type
杂志文章abstract::We show for the first time that a newly developed polyclonal antibody (pAb) can specifically target the cyanotoxin β-methylamino-L-alanine (BMAA) and can be used to enable direct visualization of BMAA entry and accumulation in primary brain cells. We used this pAb to investigate the effect of acute and chronic accumul...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9787-9
更新日期:2018-01-01 00:00:00
abstract::Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-021-00329-x
更新日期:2021-01-11 00:00:00
abstract::Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotrans...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033568
更新日期:2007-04-01 00:00:00
abstract::Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033288
更新日期:2000-02-01 00:00:00
abstract::Maillard reactions have been explored by food chemists for many years. It is only recently that the advanced glycation end products (AGEs), the end products of the Maillard reaction, have been detected in a wide variety of diseases such as diabetes, atherosclerosis, cataractogenesis, Parkinson disease and Alzheimer di...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/1029840290007321
更新日期:2002-05-01 00:00:00
abstract::A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9979-y
更新日期:2019-04-01 00:00:00
abstract::This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9235-6
更新日期:2011-08-01 00:00:00
abstract::Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033357
更新日期:2006-12-01 00:00:00
abstract::Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9588-y
更新日期:2016-04-01 00:00:00
abstract::Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9570-8
更新日期:2016-01-01 00:00:00
abstract::The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290007592
更新日期:2002-02-01 00:00:00
abstract::Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9250-2
更新日期:2011-11-01 00:00:00
abstract::The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-019-00051-9
更新日期:2019-11-01 00:00:00
abstract::In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9613-9
更新日期:2016-07-01 00:00:00
abstract::The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9508-6
更新日期:2015-02-01 00:00:00
abstract::Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-010-9163-5
更新日期:2010-11-01 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9049-6
更新日期:2009-07-01 00:00:00
abstract::Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9440-1
更新日期:2014-05-01 00:00:00
abstract::The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033804
更新日期:2008-10-01 00:00:00
abstract::GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033861
更新日期:2008-12-01 00:00:00
abstract::Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9028-y
更新日期:2009-04-01 00:00:00
abstract::Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00294-x
更新日期:2020-10-06 00:00:00
abstract::Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033264
更新日期:2001-07-01 00:00:00
abstract::Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in hum...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9067-4
更新日期:2010-01-01 00:00:00
abstract::Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and Glo systems were in...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9738-5
更新日期:2017-10-01 00:00:00
abstract::Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00163-7
更新日期:2020-03-01 00:00:00
abstract::Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00017-x
更新日期:2019-07-01 00:00:00
abstract::Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9063-8
更新日期:2009-08-01 00:00:00
abstract::Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00231-y
更新日期:2020-08-01 00:00:00
abstract::The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9244-0
更新日期:2011-11-01 00:00:00