Abstract：
:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation and compared to controls. Brains were examined histopathologically using the De Olmos cupric silver staining. Additionally, a summation score of the density of apoptotic cells was calculated for every brain. Spatial memory learning was assessed by the Morris Water Maze (MWM) test and the hole board test, performed in 7 weeks old animals who underwent the same anesthetic procedure. Brains of propofol-treated animals showed a significant higher neurodegenerative summation score (24,345) when compared to controls (15,872) and to sevoflurane-treated animals (18,870). Treated animals also demonstrated persistent learning deficits in the hole board test, whereas the MWM test revealed no differences between both groups. Among other substances acting via GABAA agonism and/or NMDA antagonism propofol induced neurodegeneration in newborn rat brains whereas a sevoflurane based anesthesia did not. The significance of these results for clinical anesthesia has not been completely elucidated. Future studies have to focus on the detection of safe anesthetic strategies for the developing brain.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Bercker S,Bert B,Bittigau P,Felderhoff-Müser U,Bührer C,Ikonomidou C,Weise M,Kaisers UX,Kerner Tdoi
10.1007/s12640-009-9063-8subject
Has Abstractpub_date
2009-08-01 00:00:00pages
140-7issue
2eissn
1029-8428issn
1476-3524journal_volume
16pub_type
杂志文章abstract：:The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00051-9
更新日期：2019-11-01 00:00:00
abstract：:Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. A sublethal preconditioning has been proposed as a neuroprotective strategy against several central nervous system neurodegenerative diseases. We have recently demonstrated that autophagy is a pr...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9390-7
更新日期：2013-11-01 00:00:00
abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9979-y
更新日期：2019-04-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00144-5
更新日期：2020-04-01 00:00:00
abstract：:Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and Glo systems were in...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9738-5
更新日期：2017-10-01 00:00:00
abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033901
更新日期：2007-07-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033367
更新日期：2008-01-01 00:00:00
abstract：:C57/BL6 mice were administered either 7.5 mg Fe (II)/ kg or vehicle (saline) postnatally on Days 10-12 after birth. From 64 days of age onwards for 24 days, groups of mice were administered either haloperidol (0.25 or 1 or 2 mg/kg, s.c.) or vehicle (Tween-80). Twenty-four hours after the final injection of either neur...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033321
更新日期：2006-06-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9427-y
更新日期：2014-07-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9905-3
更新日期：2018-10-01 00:00:00
abstract：:The nucleus accumbens (Nacc) and medial prefrontal cortex (mPFC) receive dopaminergic innervation from the ventral tegmental area and are involved in learning. Male rats with 6-hydroxydopamine (6-OHDA)-induced dopaminergic and noradrenergic reductions in the Nacc or mPFC were tested for allocentric and egocentric lear...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9616-6
更新日期：2016-08-01 00:00:00
abstract：:Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9180-4
更新日期：2011-04-01 00:00:00
abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00163-7
更新日期：2020-03-01 00:00:00
abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033357
更新日期：2006-12-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290023963
更新日期：2002-06-01 00:00:00
abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033778
更新日期：2005-01-01 00:00:00
abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9611-y
更新日期：2016-08-01 00:00:00
abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9403-6
更新日期：2013-10-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033151
更新日期：2003-01-01 00:00:00
abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...
journal_title：Neurotoxicity research
pub_type： 历史文章,杂志文章,评审
doi：10.1007/BF03033223
更新日期：2004-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9556-6
更新日期：2016-04-01 00:00:00
abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9054-9
更新日期：2009-10-01 00:00:00
abstract：:The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuro...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9566-4
更新日期：2016-01-01 00:00:00
abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9125-y
更新日期：2010-05-01 00:00:00
abstract：:Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9554-8
更新日期：2016-01-01 00:00:00
abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9451-y
更新日期：2014-07-01 00:00:00
abstract：:Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9153-7
更新日期：2011-01-01 00:00:00
abstract：:Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross blood brain barrier and received considerable attention for its neuroprotective role. We have reported the benefit of AA against aluminum chloride (AlCl3)-induced amyloid pathology, enhanced acetylcholine esterase (AChE) act...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-9999-2
更新日期：2019-05-01 00:00:00
abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033284
更新日期：2004-01-01 00:00:00
