Effect of Combined Prenatal and Adult Benzophenone-3 Dermal Exposure on Factors Regulating Neurodegenerative Processes, Blood Hormone Levels, and Hematological Parameters in Female Rats.

abstract：:Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and Glo systems were in...

journal_title：Neurotoxicity research

authors： Schmitz AE,de Souza LF,Dos Santos B,Maher P,Lopes FM,Londero GF,Klamt F,Dafre AL

更新日期：2017-10-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

journal_title：Neurotoxicity research

authors： Hansen B

更新日期：2020-01-01 00:00:00

abstract：:We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...

journal_title：Neurotoxicity research

authors： Lespay-Rebolledo C,Tapia-Bustos A,Bustamante D,Morales P,Herrera-Marschitz M

更新日期：2019-10-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induct...

journal_title：Neurotoxicity research

authors： Rauš S,Selaković V,Manojlović-Stojanoski M,Radenović L,Prolić Z,Janać B

更新日期：2013-01-01 00:00:00

abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...

journal_title：Neurotoxicity research

authors： Dikshit P,Goswami A,Mishra A,Chatterjee M,Jana NR

更新日期：2006-01-01 00:00:00

abstract：:Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

journal_title：Neurotoxicity research

authors： Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

更新日期：2020-04-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...

journal_title：Neurotoxicity research

authors： Echeverry C,Arredondo F,Martínez M,Abin-Carriquiry JA,Midiwo J,Dajas F

更新日期：2015-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...

journal_title：Neurotoxicity research

authors： K C S,Kakoty V,Marathe S,Chitkara D,Taliyan R

更新日期：2020-07-18 00:00:00

abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

journal_title：Neurotoxicity research

authors： von Bernhardi R

更新日期：2007-12-01 00:00:00

abstract：:In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...

journal_title：Neurotoxicity research

authors： Pérez-Núñez R,Barraza N,Gonzalez-Jamett A,Cárdenas AM,Barnier JV,Caviedes P

更新日期：2016-07-01 00:00:00

abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...

journal_title：Neurotoxicity research

authors： Masserano JM,Baker I,Venable D,Gong L,Zullo SJ,Merril CR,Wyatt RJ

更新日期：2000-02-01 00:00:00

abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

journal_title：Neurotoxicity research

authors： Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

更新日期：2019-04-01 00:00:00

abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...

journal_title：Neurotoxicity research

authors： Herpin G,Gargouri I,Gauchard GC,Nisse C,Khadhraoui M,Elleuch B,Zmirou-Navier D,Perrin PP

更新日期：2009-02-01 00:00:00

abstract：:L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...

journal_title：Neurotoxicity research

authors： Yang Z,Wang X,Yang J,Sun M,Wang Y,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...

journal_title：Neurotoxicity research

authors： Yang CR,Zhang XY,Liu Y,Du JY,Liang R,Yu M,Zhang FQ,Mu XF,Li F,Zhou L,Zhou FH,Meng FJ,Wang S,Ming D,Zhou XF

更新日期：2020-01-01 00:00:00

abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...

journal_title：Neurotoxicity research

authors： King TD,Clodfelder-Miller B,Barksdale KA,Bijur GN

更新日期：2008-12-01 00:00:00

abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...

journal_title：Neurotoxicity research

authors： Wang B,Zhao J,Yu M,Meng X,Cui X,Zhao Y,Zhu Y,Xing W,Guan Y

更新日期：2014-07-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...

journal_title：Neurotoxicity research

authors： Rodriguez-Navarro AJ,Lagos M,Figueroa C,Garcia C,Recabal P,Silva P,Iglesias V,Lagos N

更新日期：2009-11-01 00:00:00

abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Segura-Aguilar J

更新日期：2003-01-01 00:00:00

abstract：:The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...

journal_title：Neurotoxicity research

authors： Colamartino M,Santoro M,Duranti G,Sabatini S,Ceci R,Testa A,Padua L,Cozzi R

更新日期：2015-02-01 00:00:00

abstract：:The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...

journal_title：Neurotoxicity research

authors： Kouri G,Theophilidis G

更新日期：2002-02-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...

journal_title：Neurotoxicity research

authors： Ślusarczyk J,Piotrowski M,Szczepanowicz K,Regulska M,Leśkiewicz M,Warszyński P,Budziszewska B,Lasoń W,Basta-Kaim A

更新日期：2016-11-01 00:00:00

abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...

journal_title：Neurotoxicity research

authors： Hempstead BL

更新日期：2009-10-01 00:00:00

abstract：:Neuronal cell death caused by pathophysiological over-activation of glutamate receptors and the subsequent CaII overloading, has been implicated in neurodegeneration after stroke, cerebral trauma and epileptic seizures. Recent findings suggest that certain progesterone metabolites (neurosteroids) such as allopregnanol...

journal_title：Neurotoxicity research

authors： Xilouri M,Papazafiri P

更新日期：2008-05-01 00:00:00

abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...

journal_title：Neurotoxicity research

authors： Nagesh Babu G,Kumar A,Singh RL

更新日期：2011-02-01 00:00:00

abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

journal_title：Neurotoxicity research

authors： Lv ZY,Tan CC,Yu JT,Tan L

更新日期：2017-11-01 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00