Influence of In Vitro Electrical Stimulation on Survival of Spiral Ganglion Neurons.

abstract：:Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...

journal_title：Neurotoxicity research

authors： Huang CW,Cheng JT,Tsai JJ,Wu SN,Huang CC

更新日期：2009-01-01 00:00:00

abstract：:In the slowly progressive neurodegenerative disorders like Parkinson's disease and Alzheimer's disease very different neuronal populations undergo degenerative processes, although the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkins...

journal_title：Neurotoxicity research

authors： Pedersen V,Schmidt WJ

更新日期：2000-01-01 00:00:00

abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...

journal_title：Neurotoxicity research

authors： Nagesh Babu G,Kumar A,Singh RL

更新日期：2011-02-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Zelek-Molik A,Nalepa I,Antkiewicz-Michaluk L

更新日期：2016-04-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

journal_title：Neurotoxicity research

authors： Hansen B

更新日期：2020-01-01 00:00:00

abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

journal_title：Neurotoxicity research

authors： Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

更新日期：2019-05-01 00:00:00

abstract：:Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...

journal_title：Neurotoxicity research

authors： Chun HJ,Lee Y,Kim AH,Lee J

更新日期：2016-04-01 00:00:00

abstract：:Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective...

journal_title：Neurotoxicity research

authors： Shi TY,Feng SF,Xing JH,Wu YM,Li XQ,Zhang N,Tian Z,Liu SB,Zhao MG

更新日期：2012-05-01 00:00:00

abstract：:L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...

journal_title：Neurotoxicity research

authors： Yang Z,Wang X,Yang J,Sun M,Wang Y,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Organophosphate (OP) poisoning is associated with long-lasting neurological damage, which is attributed mainly to the excessive levels of glutamate caused by the intoxication. Glutamate toxicity, however, is not specific to OP poisoning, and is linked to propagation of damage in both acute and chronic neurodegenerativ...

journal_title：Neurotoxicity research

authors： Eisenkraft A,Falk A,Finkelstein A

更新日期：2013-08-01 00:00:00

abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...

journal_title：Neurotoxicity research

authors： Kowalczyk-Pachel D,Chwatko G,Iciek M,Czyżyk J,Filip M,Włodek L,Lorenc-Koci E

更新日期：2013-10-01 00:00:00

abstract：:Cultured rat fibroblasts, monkey kidney tumor cells (line Vero) and murine neuroblastoma cells were exposed to dopamine or dopaminochrome in the presence and absence of ascorbic acid. Ascorbic acid is able to potentiate the toxicity of both dopamine and dopaminochrome for all the tested cells. The toxicity of dopamino...

journal_title：Neurotoxicity research

authors： Galzigna L,Zanatta L,Esposito N

更新日期：1999-12-01 00:00:00

abstract：:Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...

journal_title：Neurotoxicity research

authors： Songin M,Strosznajder JB,Fitał M,Kuter K,Kolasiewicz W,Nowak P,Ossowska K

更新日期：2011-01-01 00:00:00

abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...

journal_title：Neurotoxicity research

authors： Honson NS,Jensen JR,Abraha A,Hall GF,Kuret J

更新日期：2009-04-01 00:00:00

abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...

journal_title：Neurotoxicity research

authors： Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar J

更新日期：2004-01-01 00:00:00

abstract：:Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...

journal_title：Neurotoxicity research

authors： Brus R,Jochem J,Nowak P,Adwent M,Boroń D,Brus H,Kostrzewa RM

更新日期：2012-02-01 00:00:00

abstract：:There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...

journal_title：Neurotoxicity research

authors： Brown D,Tamas A,Reglodi D,Tizabi Y

更新日期：2014-10-01 00:00:00

abstract：:1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...

journal_title：Neurotoxicity research

authors： Antkiewicz-Michaluk L,Wąsik A,Romańska I,Bojarski A,Michaluk J

更新日期：2011-08-01 00:00:00

abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

journal_title：Neurotoxicity research

authors： Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

更新日期：2020-03-01 00:00:00

abstract：:Methamphetamine (METH) is an illicit drug that is also neurotoxic. Recent studies suggest that in addition to dopamine terminal degeneration in the striatum, METH causes apoptosis in cortical neurons. Earlier, we showed that c-fos knockout mice are more susceptible to the toxic effects of the drug. In order to identif...

journal_title：Neurotoxicity research

authors： Betts ES,Krasnova IN,McCoy MT,Ladenheim B,Cadet JL

更新日期：2002-11-01 00:00:00

abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...

journal_title：Neurotoxicity research

authors： Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler G

更新日期：2019-11-01 00:00:00

abstract：:Impulse control disorders (ICDs) comprise a wide spectrum of abnormal behaviors frequently found in patients with Parkinson's disease (PD) receiving antiparkinsonian treatment. Some ICDs share several essential features with substance use disorders. In this work, we have studied the addiction-related gene ankyrin repe...

journal_title：Neurotoxicity research

authors： Hoenicka J,García-Ruiz PJ,Ponce G,Herranz A,Martínez-Rubio D,Pérez-Santamarina E,Palau F

更新日期：2015-04-01 00:00:00

abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...

journal_title：Neurotoxicity research

authors： Koohpeyma H,Goudarzi I,Elahdadi Salmani M,Lashkarbolouki T,Shabani M

更新日期：2019-04-01 00:00:00

abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

journal_title：Neurotoxicity research

authors： Lv ZY,Tan CC,Yu JT,Tan L

更新日期：2017-11-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...

journal_title：Neurotoxicity research

authors： Fisher D,Gamieldien K,Mafunda PS

更新日期：2015-07-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...

journal_title：Neurotoxicity research

authors： Hemendinger RA,Armstrong EJ 3rd,Persinski R,Todd J,Mougeot JL,Volvovitz F,Rosenfeld J

更新日期：2008-01-01 00:00:00

abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...

journal_title：Neurotoxicity research

authors： Sadakierska-Chudy A,Filip M

更新日期：2015-02-01 00:00:00