Analysis of methamphetamine-induced changes in the expression of integrin family members in the cortex of wild-type and c-fos knockout mice.

abstract：:Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...

journal_title：Neurotoxicity research

authors： Kuszczyk MA,Sadowski MJ,Antkiewicz-Michaluk L,Lazarewicz JW

更新日期：2014-05-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...

journal_title：Neurotoxicity research

authors： Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler G

更新日期：2019-11-01 00:00:00

abstract：:Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...

journal_title：Neurotoxicity research

authors： Chun HJ,Lee Y,Kim AH,Lee J

更新日期：2016-04-01 00:00:00

abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...

journal_title：Neurotoxicity research

authors： Wang Y,Musich PR,Serrano MA,Zou Y,Zhang J,Zhu MY

更新日期：2014-02-01 00:00:00

abstract：:The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...

journal_title：Neurotoxicity research

authors： Lau WK,Mak JC,Chan KH,Law AC

更新日期：2012-08-01 00:00:00

abstract：:Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...

journal_title：Neurotoxicity research

authors： Lameth J,Gervais A,Colin C,Lévêque P,Jay TM,Edeline JM,Mallat M

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

journal_title：Neurotoxicity research

authors： Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

更新日期：2020-03-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00

abstract：:Mercury is a ubiquitous contaminant, and a range of chemical species is generated by human activity and natural environmental change. Elemental mercury and its inorganic and organic compounds have different toxic properties, but all them are considered hazardous in human exposure. In an equimolecular exposure basis, o...

journal_title：Neurotoxicity research

authors： Sanfeliu C,Sebastià J,Cristòfol R,Rodríguez-Farré E

更新日期：2003-01-01 00:00:00

abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

journal_title：Neurotoxicity research

authors： Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

更新日期：2020-03-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...

journal_title：Neurotoxicity research

authors： Koohpeyma H,Goudarzi I,Elahdadi Salmani M,Lashkarbolouki T,Shabani M

更新日期：2019-04-01 00:00:00

abstract：:Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

journal_title：Neurotoxicity research

authors： Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

更新日期：2020-04-01 00:00:00

abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...

journal_title：Neurotoxicity research

authors： Kowalczyk-Pachel D,Chwatko G,Iciek M,Czyżyk J,Filip M,Włodek L,Lorenc-Koci E

更新日期：2013-10-01 00:00:00

abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Zelek-Molik A,Antkiewicz-Michaluk L

更新日期：2018-04-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...

journal_title：Neurotoxicity research

authors： da Silva WMB,de Oliveira Pinheiro S,Alves DR,de Menezes JESA,Magalhães FEA,Silva FCO,Silva J,Marinho ES,de Morais SM

更新日期：2020-04-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In...

journal_title：Neurotoxicity research

authors： Borroto-Escuela DO,Romero-Fernandez W,Wydra K,Zhou Z,Suder A,Filip M,Fuxe K

更新日期：2020-02-01 00:00:00

abstract：:Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...

journal_title：Neurotoxicity research

authors： Itoh T,Satou T,Nishida S,Tsubaki M,Hashimoto S,Ito H

更新日期：2009-11-01 00:00:00

abstract：:Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...

journal_title：Neurotoxicity research

authors： Huang CW,Cheng JT,Tsai JJ,Wu SN,Huang CC

更新日期：2009-01-01 00:00:00

abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...

journal_title：Neurotoxicity research

authors： Newcomb JD,Brown WD,Rodriguez AI,Garbuzova-Davis S,Saporta S,Sanberg PR,Willing AE

更新日期：2005-11-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingeste...

journal_title：Neurotoxicity research

authors： Górska AM,Kamińska K,Wawrzczak-Bargieła A,Costa G,Morelli M,Przewłocki R,Kreiner G,Gołembiowska K

更新日期：2018-04-01 00:00:00

abstract：:L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...

journal_title：Neurotoxicity research

authors： Yang Z,Wang X,Yang J,Sun M,Wang Y,Wang X

更新日期：2017-04-01 00:00:00

abstract：:Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...

journal_title：Neurotoxicity research

authors： Yang CR,Zhang XY,Liu Y,Du JY,Liang R,Yu M,Zhang FQ,Mu XF,Li F,Zhou L,Zhou FH,Meng FJ,Wang S,Ming D,Zhou XF

更新日期：2020-01-01 00:00:00

abstract：:Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...

journal_title：Neurotoxicity research

authors： Nieoczym D,Socała K,Jedziniak P,Wyska E,Wlaź P

更新日期：2019-11-01 00:00:00

abstract：:In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...

journal_title：Neurotoxicity research

authors： Sadakierska-Chudy A,Kostrzewa RM,Filip M

更新日期：2015-01-01 00:00:00

abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...

journal_title：Neurotoxicity research

authors： Villani L,Beraudi A,Giuliani A,Poli A

更新日期：2001-07-01 00:00:00

abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

journal_title：Neurotoxicity research

authors： Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

更新日期：2019-04-01 00:00:00