Abstract:
:Cultured rat fibroblasts, monkey kidney tumor cells (line Vero) and murine neuroblastoma cells were exposed to dopamine or dopaminochrome in the presence and absence of ascorbic acid. Ascorbic acid is able to potentiate the toxicity of both dopamine and dopaminochrome for all the tested cells. The toxicity of dopaminochrome was higher than that of dopamine. There is a correlation between toxicity and levels of bioreductive defenses of the cells, e.g. DT-diaphorase (NAD(P)H:quinone oxidoreductase EC 1.6.99.2) and glutathione. In general, tumor cells have lower defenses and seem to be more sensitive to the toxic action.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Galzigna L,Zanatta L,Esposito Ndoi
10.1007/BF03033278keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
149-52issue
2eissn
1029-8428issn
1476-3524journal_volume
1pub_type
杂志文章abstract::Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9180-4
更新日期:2011-04-01 00:00:00
abstract::In the slowly progressive neurodegenerative disorders like Parkinson's disease and Alzheimer's disease very different neuronal populations undergo degenerative processes, although the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkins...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033793
更新日期:2000-01-01 00:00:00
abstract::2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00252-7
更新日期:2020-10-01 00:00:00
abstract::Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00163-7
更新日期:2020-03-01 00:00:00
abstract::Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033901
更新日期:2007-07-01 00:00:00
abstract::Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00294-x
更新日期:2020-10-06 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9556-6
更新日期:2016-04-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033183
更新日期:2004-01-01 00:00:00
abstract::The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9403-6
更新日期:2013-10-01 00:00:00
abstract::Cognitive impairment in depression may be one of the more practically important aspects of the illness, responsible for much of its morbidity. It also is at the heart of its psychopathology, may contribute to strategies of treatment, and may give us a more easily quantifiable measure of impaired function to correlate ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033237
更新日期:2006-10-01 00:00:00
abstract::Methamphetamine (METH) is an illicit drug that is also neurotoxic. Recent studies suggest that in addition to dopamine terminal degeneration in the striatum, METH causes apoptosis in cortical neurons. Earlier, we showed that c-fos knockout mice are more susceptible to the toxic effects of the drug. In order to identif...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/1029842021000045453
更新日期:2002-11-01 00:00:00
abstract::Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9460-5
更新日期:2014-08-01 00:00:00
abstract::Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9967-2
更新日期:2019-04-01 00:00:00
abstract::Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9028-y
更新日期:2009-04-01 00:00:00
abstract::It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9316-9
更新日期:2012-08-01 00:00:00
abstract::Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033380
更新日期:2003-01-01 00:00:00
abstract::Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9008-2
更新日期:2009-01-01 00:00:00
abstract::Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9369-9
更新日期:2013-08-01 00:00:00
abstract::Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9054-9
更新日期:2009-10-01 00:00:00
abstract::Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9696-3
更新日期:2017-05-01 00:00:00
abstract::Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9800-3
更新日期:2018-02-01 00:00:00
abstract::The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9495-7
更新日期:2015-02-01 00:00:00
abstract::Sepsis-associated encephalopathy causes brain dysfunction that can result in cognitive impairments in sepsis survivor patients. In previous work, we showed that simvastatin attenuated oxidative stress in brain structures related to memory in septic rats. However, there is still a need to evaluate the long-term impact ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00222-z
更新日期:2020-12-01 00:00:00
abstract::In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9497-5
更新日期:2015-01-01 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9049-6
更新日期:2009-07-01 00:00:00
abstract::High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9018-0
更新日期:2009-02-01 00:00:00
abstract::During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033229
更新日期:2001-01-01 00:00:00
abstract::The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9838-2
更新日期:2019-01-01 00:00:00
abstract::The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...
journal_title:Neurotoxicity research
pub_type: 已发布勘误
doi:10.1007/s12640-018-9982-3
更新日期:2019-05-01 00:00:00
abstract::There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9468-x
更新日期:2014-10-01 00:00:00