Glycyrrhizic Acid Ameliorates Mitochondrial Function and Biogenesis Against Aluminum Toxicity in PC12 Cells.

abstract：:Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...

journal_title：Neurotoxicity research

authors： Itoh T,Satou T,Nishida S,Tsubaki M,Hashimoto S,Ito H

更新日期：2009-11-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...

journal_title：Neurotoxicity research

authors： Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar J

更新日期：2004-01-01 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...

journal_title：Neurotoxicity research

authors： Blackwood DH,Pickard BJ,Thomson PA,Evans KL,Porteous DJ,Muir WJ

更新日期：2007-01-01 00:00:00

abstract：:The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...

journal_title：Neurotoxicity research

authors： Lau WK,Mak JC,Chan KH,Law AC

更新日期：2012-08-01 00:00:00

abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...

journal_title：Neurotoxicity research

authors： Fernandez LL,de Lima MN,Scalco F,Vedana G,Miwa C,Hilbig A,Vianna M,Schröder N

更新日期：2011-08-01 00:00:00

abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...

journal_title：Neurotoxicity research

authors： Endesfelder S,Weichelt U,Schiller C,Winter K,von Haefen C,Bührer C

更新日期：2018-08-01 00:00:00

abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...

journal_title：Neurotoxicity research

authors： Fernandes CG,Pierozan P,Soares GM,Ferreira F,Zanatta Â,Amaral AU,Borges CG,Wajner M,Pessoa-Pureur R

更新日期：2015-10-01 00:00:00

abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...

journal_title：Neurotoxicity research

authors： Cuevas C,Huenchuguala S,Muñoz P,Villa M,Paris I,Mannervik B,Segura-Aguilar J

更新日期：2015-04-01 00:00:00

abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

journal_title：Neurotoxicity research

authors： de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

更新日期：2019-10-01 00:00:00

abstract：:Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...

journal_title：Neurotoxicity research

authors： Romero AM,Palanca A,Ruiz-Soto M,Llorca J,Marín MP,Renau-Piqueras J,Berciano MT,Lafarga M

更新日期：2016-01-01 00:00:00

abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...

journal_title：Neurotoxicity research

authors： Echeverry C,Arredondo F,Martínez M,Abin-Carriquiry JA,Midiwo J,Dajas F

更新日期：2015-01-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...

journal_title：Neurotoxicity research

authors： Milosevic J,Adler I,Manaenko A,Schwarz SC,Walkinshaw G,Arend M,Flippin LA,Storch A,Schwarz J

更新日期：2009-05-01 00:00:00

abstract：:Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the...

journal_title：Neurotoxicity research

authors： Yu ZY,Li WW,Yang HM,Mañucat-Tan NB,Wang J,Wang YR,Sun BL,Hu ZC,Zhang LL,Tan L,Deng J,Liu YH

更新日期：2020-04-01 00:00:00

abstract：:Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...

journal_title：Neurotoxicity research

authors： Kurnik-Łucka M,Latacz G,Martyniak A,Bugajski A,Kieć-Kononowicz K,Gil K

更新日期：2020-02-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...

journal_title：Neurotoxicity research

authors： Mishra AK,Mishra S,Rajput C,Ur Rasheed MS,Patel DK,Singh MP

更新日期：2018-02-01 00:00:00

abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Dziubina A

更新日期：2012-08-01 00:00:00

abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...

journal_title：Neurotoxicity research

authors： Hinduja S,Kraus KS,Manohar S,Salvi RJ

更新日期：2015-04-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Mercury is a ubiquitous contaminant, and a range of chemical species is generated by human activity and natural environmental change. Elemental mercury and its inorganic and organic compounds have different toxic properties, but all them are considered hazardous in human exposure. In an equimolecular exposure basis, o...

journal_title：Neurotoxicity research

authors： Sanfeliu C,Sebastià J,Cristòfol R,Rodríguez-Farré E

更新日期：2003-01-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...

journal_title：Neurotoxicity research

authors： Copeland RL Jr,Das JR,Kanaan YM,Taylor RE,Tizabi Y

更新日期：2007-07-01 00:00:00

abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...

journal_title：Neurotoxicity research

authors： Li F,Wang XS,Dai RP,Zhang JY,Zhou XF,Hao W,Li CQ

更新日期：2011-11-01 00:00:00

abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...

journal_title：Neurotoxicity research

authors： Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli M

更新日期：2010-05-01 00:00:00

abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...

journal_title：Neurotoxicity research

authors： Dircio-Bautista M,Colín-González AL,Aguilera G,Maya-López M,Villeda-Hernández J,Galván-Arzate S,García E,Túnez I,Santamaría A

更新日期：2018-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Zelek-Molik A,Nalepa I,Antkiewicz-Michaluk L

更新日期：2016-04-01 00:00:00

abstract：:Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...

journal_title：Neurotoxicity research

authors： Wang HT,Huang FL,Hu ZL,Zhang WJ,Qiao XQ,Huang YQ,Dai RP,Li F,Li CQ

更新日期：2017-05-01 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...

journal_title：Neurotoxicity research

authors： Antkiewicz-Michaluk L,Wąsik A,Romańska I,Bojarski A,Michaluk J

更新日期：2011-08-01 00:00:00