Abstract:
:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side effects, induces apoptosis and suppresses neurogenesis in the hippocampus leading to memory impairment. Previous studies have shown that the antioxidant D-methionine protects against cisplatin-induced ototoxicity and nephrotoxicity suggesting that it might also prevent neurogenesis from being suppressed by cisplatin treatment. To test this hypothesis, rats were treated with cisplatin, D-methionine, cisplatin plus D-methionine, or saline (controls). Seven days after treatment, the rats were sacrificed, and hippocampal sections immunolabeled for doublecortin (DCX) to identify neuronal precursor cells and maturing neurons in the SGZ. Cisplatin significantly reduced the number of DCX-labeled cells (~80 %) relative to controls. In contrast, DCX cell counts in rats treated with D-methionine prior to cisplatin were similar to controls. The treatment with D-methionine alone did not affect the number of DCX cells. These results indicate that D-methionine prevents the dramatic cisplatin-induced decrease of neurogenesis.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Hinduja S,Kraus KS,Manohar S,Salvi RJdoi
10.1007/s12640-014-9503-ysubject
Has Abstractpub_date
2015-04-01 00:00:00pages
199-204issue
3eissn
1029-8428issn
1476-3524journal_volume
27pub_type
杂志文章abstract::Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title:Neurotoxicity research
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pub_type: 杂志文章,多中心研究
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-010-9153-7
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033321
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9468-x
更新日期:2014-10-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9556-6
更新日期:2016-04-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9390-7
更新日期:2013-11-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033311
更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9476-x
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9300-9
更新日期:2012-07-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9740-y
更新日期:2018-01-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-010-9228-5
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00091-1
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9301-8
更新日期:2012-08-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-020-00294-x
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9321-z
更新日期:2013-01-01 00:00:00
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-014-9508-6
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9686-5
更新日期:2017-04-01 00:00:00
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journal_title:Neurotoxicity research
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