Abstract:
:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood mercury concentrations in children and ASDs. Moreover, we investigated the role of seafood consumption in relation to blood mercury concentrations in Jamaican children. Based on data for 65 sex- and age-matched pairs (2-8 years), we used a General Linear Model to test whether there is an association between blood mercury concentrations and ASDs. After controlling for the child's frequency of seafood consumption, maternal age, and parental education, we did not find a significant difference (P = 0.61) between blood mercury concentrations and ASDs. However, in both cases and control groups, children who ate certain types of seafood (i.e., salt water fish, sardine, or mackerel fish) had significantly higher (all P < 0.05) geometric means blood mercury concentration which were about 3.5 times that of children living in the US or Canada. Our findings also indicate that Jamaican children with parents who both had education up to high school are at a higher risk of exposure to mercury compared to children with at least one parent who had education beyond high school. Based on our findings, we recommend additional education to Jamaican parents regarding potential hazards of elevated blood mercury concentrations, and its association with seafood consumption and type of seafood.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Rahbar MH,Samms-Vaughan M,Loveland KA,Ardjomand-Hessabi M,Chen Z,Bressler J,Shakespeare-Pellington S,Grove ML,Bloom K,Pearson DA,Lalor GC,Boerwinkle Edoi
10.1007/s12640-012-9321-zsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
22-38issue
1eissn
1029-8428issn
1476-3524journal_volume
23pub_type
杂志文章abstract::Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...
journal_title:Neurotoxicity research
pub_type: 杂志文章
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abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00154-3
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abstract::Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title:Neurotoxicity research
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更新日期:2011-11-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290007592
更新日期:2002-02-01 00:00:00
abstract::Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033291
更新日期:2004-01-01 00:00:00
abstract::Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures...
journal_title:Neurotoxicity research
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doi:10.1007/BF03033437
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abstract::Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...
journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-011-9251-1
更新日期:2012-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章,多中心研究
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033804
更新日期:2008-10-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9067-4
更新日期:2010-01-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-015-9566-4
更新日期:2016-01-01 00:00:00
abstract::Methamphetamine (METH) is an illicit drug that is also neurotoxic. Recent studies suggest that in addition to dopamine terminal degeneration in the striatum, METH causes apoptosis in cortical neurons. Earlier, we showed that c-fos knockout mice are more susceptible to the toxic effects of the drug. In order to identif...
journal_title:Neurotoxicity research
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doi:10.1080/1029842021000045453
更新日期:2002-11-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-009-9125-y
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doi:10.1007/s12640-015-9532-1
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9301-8
更新日期:2012-08-01 00:00:00
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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更新日期:2014-05-01 00:00:00
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journal_title:Neurotoxicity research
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更新日期:2018-08-01 00:00:00
abstract::The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...
journal_title:Neurotoxicity research
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doi:10.1007/s12640-014-9495-7
更新日期:2015-02-01 00:00:00
abstract::The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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journal_title:Neurotoxicity research
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更新日期:2015-05-01 00:00:00
abstract::Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...
journal_title:Neurotoxicity research
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abstract::GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033861
更新日期:2008-12-01 00:00:00
abstract::Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00021-1
更新日期:2019-11-01 00:00:00
abstract::Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9696-3
更新日期:2017-05-01 00:00:00