PACAP protects against inflammatory-mediated toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease.

abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...

journal_title：Neurotoxicity research

authors： Li Y,Ding D,Jiang H,Fu Y,Salvi R

更新日期：2011-11-01 00:00:00

abstract：:The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...

journal_title：Neurotoxicity research

authors： Li H,Song S,Wang Y,Huang C,Zhang F,Liu J,Hong JS

更新日期：2019-05-01 00:00:00

abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...

journal_title：Neurotoxicity research

authors： Lipska BK,Weinberger DR

更新日期：2002-08-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...

journal_title：Neurotoxicity research

authors： King TD,Clodfelder-Miller B,Barksdale KA,Bijur GN

更新日期：2008-12-01 00:00:00

abstract：:Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...

journal_title：Neurotoxicity research

authors： Kikuchi-Utsumi K,Ishizaka M,Matsumura N,Watabe M,Aoyama K,Sasakawa N,Nakaki T

更新日期：2013-08-01 00:00:00

abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...

journal_title：Neurotoxicity research

authors： Beninger RJ,Gerdjikov T

更新日期：2004-01-01 00:00:00

abstract：:Methamphetamine (METH) is an illicit drug that is also neurotoxic. Recent studies suggest that in addition to dopamine terminal degeneration in the striatum, METH causes apoptosis in cortical neurons. Earlier, we showed that c-fos knockout mice are more susceptible to the toxic effects of the drug. In order to identif...

journal_title：Neurotoxicity research

authors： Betts ES,Krasnova IN,McCoy MT,Ladenheim B,Cadet JL

更新日期：2002-11-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

journal_title：Neurotoxicity research

authors： Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

更新日期：2020-04-01 00:00:00

abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...

journal_title：Neurotoxicity research

authors： Hinduja S,Kraus KS,Manohar S,Salvi RJ

更新日期：2015-04-01 00:00:00

abstract：:Cultured rat fibroblasts, monkey kidney tumor cells (line Vero) and murine neuroblastoma cells were exposed to dopamine or dopaminochrome in the presence and absence of ascorbic acid. Ascorbic acid is able to potentiate the toxicity of both dopamine and dopaminochrome for all the tested cells. The toxicity of dopamino...

journal_title：Neurotoxicity research

authors： Galzigna L,Zanatta L,Esposito N

更新日期：1999-12-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...

journal_title：Neurotoxicity research

authors： Schamne MG,Mack JM,Moretti M,Matheus FC,Walz R,Lanfumey L,Prediger RD

更新日期：2018-11-01 00:00:00

abstract：:2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may cause hearing loss. Previous studies in mice have suggested that HPβCD ...

journal_title：Neurotoxicity research

authors： Liu X,Ding D,Chen GD,Li L,Jiang H,Salvi R

更新日期：2020-10-01 00:00:00

abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Kostrzewa JP,Brown RW,Nowak P,Brus R

更新日期：2008-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Zelek-Molik A,Nalepa I,Antkiewicz-Michaluk L

更新日期：2016-04-01 00:00:00

abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...

journal_title：Neurotoxicity research

authors： Cuevas C,Huenchuguala S,Muñoz P,Villa M,Paris I,Mannervik B,Segura-Aguilar J

更新日期：2015-04-01 00:00:00

abstract：:Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...

journal_title：Neurotoxicity research

authors： Han SR,Kang YH,Yoo SM,Lee MS,Lee SH

更新日期：2020-03-01 00:00:00

abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

journal_title：Neurotoxicity research

authors： Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

更新日期：2020-03-01 00:00:00

abstract：:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...

journal_title：Neurotoxicity research

authors： Tang WZ,Wang XB,Li HT,Dong M,Ji X

更新日期：2017-10-01 00:00:00

abstract：:We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...

journal_title：Neurotoxicity research

authors： Lespay-Rebolledo C,Tapia-Bustos A,Bustamante D,Morales P,Herrera-Marschitz M

更新日期：2019-10-01 00:00:00

abstract：:Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...

journal_title：Neurotoxicity research

authors： Cecatto C,Amaral AU,Leipnitz G,Castilho RF,Wajner M

更新日期：2014-08-01 00:00:00

abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...

journal_title：Neurotoxicity research

authors： Amini N,Vousooghi N,Hadjighassem M,Bakhtiyari M,Mousavi N,Safakheil H,Jafari L,Sarveazad A,Yari A,Ramezani S,Faghihi F,Joghataei MT

更新日期：2016-05-01 00:00:00

abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...

journal_title：Neurotoxicity research

authors： Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler G

更新日期：2019-11-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

journal_title：Neurotoxicity research

authors： Wojcieszak J,Kuczyńska K,Zawilska JB

更新日期：2021-01-11 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...

journal_title：Neurotoxicity research

authors： Iha HA,Kunisawa N,Shimizu S,Onishi M,Nomura Y,Matsubara N,Iwai C,Ogawa M,Hashimura M,Sato K,Kato M,Ohno Y

更新日期：2019-04-01 00:00:00