Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...

journal_title：Neurotoxicity research

authors： Bercker S,Bert B,Bittigau P,Felderhoff-Müser U,Bührer C,Ikonomidou C,Weise M,Kaisers UX,Kerner T

更新日期：2009-08-01 00:00:00

abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...

journal_title：Neurotoxicity research

authors： Masserano JM,Baker I,Venable D,Gong L,Zullo SJ,Merril CR,Wyatt RJ

更新日期：2000-02-01 00:00:00

abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...

journal_title：Neurotoxicity research

authors： Blackwood DH,Pickard BJ,Thomson PA,Evans KL,Porteous DJ,Muir WJ

更新日期：2007-01-01 00:00:00

abstract：:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...

journal_title：Neurotoxicity research

authors： Tang WZ,Wang XB,Li HT,Dong M,Ji X

更新日期：2017-10-01 00:00:00

abstract：:Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...

journal_title：Neurotoxicity research

authors： Itoh T,Satou T,Nishida S,Tsubaki M,Hashimoto S,Ito H

更新日期：2009-11-01 00:00:00

abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...

journal_title：Neurotoxicity research

authors： Nagesh Babu G,Kumar A,Singh RL

更新日期：2011-02-01 00:00:00

abstract：:The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...

journal_title：Neurotoxicity research

authors： Kowalczyk-Pachel D,Chwatko G,Iciek M,Czyżyk J,Filip M,Włodek L,Lorenc-Koci E

更新日期：2013-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...

journal_title：Neurotoxicity research

authors： Lei H,Zhang Y,Huang L,Xu S,Li J,Yang L,Wang L,Xing C,Wang X,Peng Y

更新日期：2018-10-01 00:00:00

abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...

journal_title：Neurotoxicity research

authors： Villani L,Beraudi A,Giuliani A,Poli A

更新日期：2001-07-01 00:00:00

abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...

journal_title：Neurotoxicity research

authors： Beninger RJ,Gerdjikov T

更新日期：2004-01-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...

journal_title：Neurotoxicity research

authors： Milosevic J,Adler I,Manaenko A,Schwarz SC,Walkinshaw G,Arend M,Flippin LA,Storch A,Schwarz J

更新日期：2009-05-01 00:00:00

abstract：:Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...

journal_title：Neurotoxicity research

authors： Zhang L,Qu Y,Tang B,Zhao F,Xiong T,Ferriero D,Mu D

更新日期：2012-11-01 00:00:00

abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...

journal_title：Neurotoxicity research

authors： Fisher D,Gamieldien K,Mafunda PS

更新日期：2015-07-01 00:00:00

abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...

journal_title：Neurotoxicity research

authors： Avila J,Pérez M,Lim F,Gómez-Ramos A,Hernández F,Lucas JJ

更新日期：2004-01-01 00:00:00

abstract：:Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...

journal_title：Neurotoxicity research

authors： Cecatto C,Amaral AU,Leipnitz G,Castilho RF,Wajner M

更新日期：2014-08-01 00:00:00

abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...

journal_title：Neurotoxicity research

authors： Wang W,Dow KE,Riopelle RJ,Ross GM

更新日期：2001-10-01 00:00:00

abstract：:In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...

journal_title：Neurotoxicity research

authors： Pérez-Núñez R,Barraza N,Gonzalez-Jamett A,Cárdenas AM,Barnier JV,Caviedes P

更新日期：2016-07-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...

journal_title：Neurotoxicity research

authors： Schamne MG,Mack JM,Moretti M,Matheus FC,Walz R,Lanfumey L,Prediger RD

更新日期：2018-11-01 00:00:00

abstract：:Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In...

journal_title：Neurotoxicity research

authors： Borroto-Escuela DO,Romero-Fernandez W,Wydra K,Zhou Z,Suder A,Filip M,Fuxe K

更新日期：2020-02-01 00:00:00

abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...

journal_title：Neurotoxicity research

authors： Dikshit P,Goswami A,Mishra A,Chatterjee M,Jana NR

更新日期：2006-01-01 00:00:00

abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Kajta M,Antkiewicz-Michaluk L

更新日期：2014-10-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:Cognitive impairment in depression may be one of the more practically important aspects of the illness, responsible for much of its morbidity. It also is at the heart of its psychopathology, may contribute to strategies of treatment, and may give us a more easily quantifiable measure of impaired function to correlate ...

journal_title：Neurotoxicity research

authors： Ebmeier K,Rose E,Steele D

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

journal_title：Neurotoxicity research

authors： Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

更新日期：2020-03-01 00:00:00

abstract：:Leaner mice carry a homozygous, autosomal recessive mutation in the mouse CACNA1A gene encoding the Alpha1A subunit of P/Q-type calcium channels, which results in an out-of-frame splicing event in the carboxy terminus of the Alpha1A protein. Leaner mice exhibit severe ataxia, paroxysmal dyskinesia and absence seizures...

journal_title：Neurotoxicity research

authors： Lau FC,Frank TC,Nahm SS,Stoica G,Abbott LC

更新日期：2004-01-01 00:00:00