Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.

abstract：:Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...

journal_title：Neurotoxicity research

authors： Geier DA,Geier MR

更新日期：2006-08-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

journal_title：Neurotoxicity research

authors： von Bernhardi R

更新日期：2007-12-01 00:00:00

abstract：:Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...

journal_title：Neurotoxicity research

authors： Fürstenau CR,de Souza ICC,de Oliveira MR

更新日期：2019-10-01 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...

journal_title：Neurotoxicity research

authors： Li H,Song S,Wang Y,Huang C,Zhang F,Liu J,Hong JS

更新日期：2019-05-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...

journal_title：Neurotoxicity research

authors： Beninger RJ,Gerdjikov T

更新日期：2004-01-01 00:00:00

abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...

journal_title：Neurotoxicity research

authors： Lipska BK,Weinberger DR

更新日期：2002-08-01 00:00:00

abstract：:Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...

journal_title：Neurotoxicity research

authors： Zhang H,Wang H,Xiao X,Zhang T

更新日期：2016-01-01 00:00:00

abstract：:The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...

journal_title：Neurotoxicity research

authors： Peana AT,Bassareo V,Acquas E

更新日期：2019-11-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00

abstract：:Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...

journal_title：Neurotoxicity research

authors： Brus R,Jochem J,Nowak P,Adwent M,Boroń D,Brus H,Kostrzewa RM

更新日期：2012-02-01 00:00:00

abstract：:The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...

journal_title：Neurotoxicity research

authors： Kouri G,Theophilidis G

更新日期：2002-02-01 00:00:00

abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...

journal_title：Neurotoxicity research

authors： Li Y,Ding D,Jiang H,Fu Y,Salvi R

更新日期：2011-11-01 00:00:00

abstract：:Cultured rat fibroblasts, monkey kidney tumor cells (line Vero) and murine neuroblastoma cells were exposed to dopamine or dopaminochrome in the presence and absence of ascorbic acid. Ascorbic acid is able to potentiate the toxicity of both dopamine and dopaminochrome for all the tested cells. The toxicity of dopamino...

journal_title：Neurotoxicity research

authors： Galzigna L,Zanatta L,Esposito N

更新日期：1999-12-01 00:00:00

abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...

journal_title：Neurotoxicity research

authors： Nagesh Babu G,Kumar A,Singh RL

更新日期：2011-02-01 00:00:00

abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

journal_title：Neurotoxicity research

authors： Hansen B

更新日期：2020-01-01 00:00:00

abstract：:Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...

journal_title：Neurotoxicity research

authors： Itoh T,Satou T,Nishida S,Tsubaki M,Hashimoto S,Ito H

更新日期：2009-11-01 00:00:00

abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

journal_title：Neurotoxicity research

authors： Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

更新日期：2019-05-01 00:00:00

abstract：:Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...

journal_title：Neurotoxicity research

authors： Chun HJ,Lee Y,Kim AH,Lee J

更新日期：2016-04-01 00:00:00

abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

journal_title：Neurotoxicity research

authors： Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

更新日期：2019-07-01 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

journal_title：Neurotoxicity research

authors： Wojcieszak J,Kuczyńska K,Zawilska JB

更新日期：2021-01-11 00:00:00

abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...

journal_title：Neurotoxicity research

authors： Zuo D,Lin L,Liu Y,Wang C,Xu J,Sun F,Li L,Li Z,Wu Y

更新日期：2016-08-01 00:00:00

abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...

journal_title：Neurotoxicity research

authors： Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli M

更新日期：2010-05-01 00:00:00

abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

journal_title：Neurotoxicity research

authors： de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

更新日期：2019-10-01 00:00:00

abstract：:Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...

journal_title：Neurotoxicity research

authors： Niu Q,Yang Y,Zhang Q,Niu P,He S,Di Gioacchino M,Conti P,Boscolo P

更新日期：2007-10-01 00:00:00

abstract：:Depressive symptomatology is expressed across a wide spectrum of psychiatric disorders including major depression and schizophrenia. Further, depressive symptomatology is also observed in individuals undergoing withdrawal from chronic exposure to various drugs of abuse including cocaine, amphetamine and nicotine. The ...

journal_title：Neurotoxicity research

authors： Markou A,Kenny PJ

更新日期：2002-06-01 00:00:00