A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs.

abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...

journal_title：Neurotoxicity research

authors： Villani L,Beraudi A,Giuliani A,Poli A

更新日期：2001-07-01 00:00:00

abstract：:Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery w...

journal_title：Neurotoxicity research

authors： Zhou X,Lu D,Li WD,Chen XH,Yang XY,Chen X,Zhou ZB,Ye JH,Feng X

更新日期：2018-05-01 00:00:00

abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...

journal_title：Neurotoxicity research

authors： Newcomb JD,Brown WD,Rodriguez AI,Garbuzova-Davis S,Saporta S,Sanberg PR,Willing AE

更新日期：2005-11-01 00:00:00

abstract：:Maillard reactions have been explored by food chemists for many years. It is only recently that the advanced glycation end products (AGEs), the end products of the Maillard reaction, have been detected in a wide variety of diseases such as diabetes, atherosclerosis, cataractogenesis, Parkinson disease and Alzheimer di...

journal_title：Neurotoxicity research

authors： Reddy VP,Obrenovich ME,Atwood CS,Perry G,Smith MA

更新日期：2002-05-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease (PD). Our previous studies have observed that Rg1, a major pharmacologically active ingredient from Ginseng, could protect dopaminergic neurons by reducing nigral iron levels through regulating the expression of iron transporters...

journal_title：Neurotoxicity research

authors： Du X,Xu H,Jiang H,Xie J

更新日期：2013-07-01 00:00:00

abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

journal_title：Neurotoxicity research

authors： von Bernhardi R

更新日期：2007-12-01 00:00:00

abstract：:Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...

journal_title：Neurotoxicity research

authors： Kurnik-Łucka M,Latacz G,Martyniak A,Bugajski A,Kieć-Kononowicz K,Gil K

更新日期：2020-02-01 00:00:00

abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

journal_title：Neurotoxicity research

authors： Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

更新日期：2019-07-01 00:00:00

abstract：:The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...

journal_title：Neurotoxicity research

authors： Ponce G,Hoenicka J,Rodríguez-Jiménez R,Gozalo A,Jimenéz M,Monasor R,Aragüés M,Rubio G,Jiménez-Arriero MA,Ramos JA,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

journal_title：Neurotoxicity research

authors： Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

更新日期：2020-08-01 00:00:00

abstract：:Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...

journal_title：Neurotoxicity research

authors： Wang H,Yue Y,Zhao H,Wu H,Jiang K,Li S,Zhao M,Lin F

更新日期：2021-01-05 00:00:00

abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...

journal_title：Neurotoxicity research

authors： Palomo T,Archer T,Kostrzewa RM,Beninger RJ

更新日期：2004-01-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00

abstract：:We show for the first time that a newly developed polyclonal antibody (pAb) can specifically target the cyanotoxin β-methylamino-L-alanine (BMAA) and can be used to enable direct visualization of BMAA entry and accumulation in primary brain cells. We used this pAb to investigate the effect of acute and chronic accumul...

journal_title：Neurotoxicity research

authors： Tan VX,Mazzocco C,Varney B,Bodet D,Guillemin TA,Bessede A,Guillemin GJ

更新日期：2018-01-01 00:00:00

abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...

journal_title：Neurotoxicity research

authors： Copeland RL Jr,Das JR,Kanaan YM,Taylor RE,Tizabi Y

更新日期：2007-07-01 00:00:00

abstract：:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...

journal_title：Neurotoxicity research

authors： An L,Zhang T

更新日期：2016-02-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:C57/BL6 mice were administered either 7.5 mg Fe (II)/ kg or vehicle (saline) postnatally on Days 10-12 after birth. From 64 days of age onwards for 24 days, groups of mice were administered either haloperidol (0.25 or 1 or 2 mg/kg, s.c.) or vehicle (Tween-80). Twenty-four hours after the final injection of either neur...

journal_title：Neurotoxicity research

authors： Fredriksson A,Archer T

更新日期：2006-06-01 00:00:00

abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

journal_title：Neurotoxicity research

authors： Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

更新日期：2019-04-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Dziubina A

更新日期：2012-08-01 00:00:00

abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Kajta M,Antkiewicz-Michaluk L

更新日期：2014-10-01 00:00:00

abstract：:Microglial activation and subsequent release of toxic pro-inflammatory factors are believed to play an important role in neuronal cell death associated with Parkinson's disease (PD). Compounds that inhibit microglia activation and suppress pro-inflammatory factor release have been reported to have neuroprotective effe...

journal_title：Neurotoxicity research

authors： Chinta SJ,Ganesan A,Reis-Rodrigues P,Lithgow GJ,Andersen JK

更新日期：2013-02-01 00:00:00

abstract：:Botulinum neurotoxin (BoNT) has been used clinically since 1980, with an ever-increasing range of clinical applications. This has coincided with a period of massively expanded interest in the underlying biology of the neurotoxin. Tremendous advances have taken place in the scientific understanding of neurotoxin struct...

journal_title：Neurotoxicity research

authors： Foster KA,Bigalke H,Aoki KR

更新日期：2006-04-01 00:00:00

abstract：:Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...

journal_title：Neurotoxicity research

authors： Thakur V,Jamwal S,Kumar M,Rahi V,Kumar P

更新日期：2020-08-01 00:00:00

abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...

journal_title：Neurotoxicity research

authors： Echeverry C,Arredondo F,Martínez M,Abin-Carriquiry JA,Midiwo J,Dajas F

更新日期：2015-01-01 00:00:00

abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...

journal_title：Neurotoxicity research

authors： Müller Herde A,Mihov Y,Krämer SD,Mu L,Adamantidis A,Ametamey SM,Hasler G

更新日期：2019-11-01 00:00:00

abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...

journal_title：Neurotoxicity research

authors： Wang Y,Musich PR,Serrano MA,Zou Y,Zhang J,Zhu MY

更新日期：2014-02-01 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of B...

journal_title：Neurotoxicity research

authors： Kiris E,Burnett JC,Nuss JE,Wanner LM,Peyser BD,Du HT,Gomba GY,Kota KP,Panchal RG,Gussio R,Kane CD,Tessarollo L,Bavari S

更新日期：2015-05-01 00:00:00