Assessing Cyanobacterial Harmful Algal Blooms as Risk Factors for Amyotrophic Lateral Sclerosis.


:Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways, and data availability. In this work, we develop phycocyanin concentration (i.e., CHAB exposure) maps using satellite remote sensing across northern New England to assess relationships with ALS cases using a spatial epidemiological approach. Strategic semi-analytical regression models integrated Landsat and in situ observations to map phycocyanin concentration (PC) for all lakes greater than 8 ha (n = 4117) across the region. Then, systematic versions of a Bayesian Poisson Log-linear model were fit to assess the mapped PC as a risk factor for ALS while accounting for model uncertainty and modifiable area unit problems. The satellite remote sensing of PC had strong overall ability to map conditions (adj. R2, 0.86; RMSE, 11.92) and spatial variability across the region. PC tended to be positively associated with ALS risk with the level of significance depending on fixed model components. Meta-analysis shows that when average PC exposure is 100 μg/L, an all model average odds ratio is 1.48, meaning there is about a 48% increase in average ALS risk. This research generated the first regionally comprehensive map of PC for thousands of lakes and integrated robust spatial uncertainty. The outcomes support the hypothesis that cyanotoxins increase the risk of ALS, which helps our understanding of the etiology of ALS.


Neurotox Res


Neurotoxicity research


Torbick N,Ziniti B,Stommel E,Linder E,Andrew A,Caller T,Haney J,Bradley W,Henegan PL,Shi X




Has Abstract


2018-01-01 00:00:00














  • Effects of adenosine receptor antagonists on the in vivo LPS-induced inflammation model of Parkinson's disease.

    abstract::The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

    更新日期:2013-07-01 00:00:00

  • Neurotoxicity of organomercurial compounds.

    abstract::Mercury is a ubiquitous contaminant, and a range of chemical species is generated by human activity and natural environmental change. Elemental mercury and its inorganic and organic compounds have different toxic properties, but all them are considered hazardous in human exposure. In an equimolecular exposure basis, o...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Sanfeliu C,Sebastià J,Cristòfol R,Rodríguez-Farré E

    更新日期:2003-01-01 00:00:00

  • Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities.

    abstract::The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: da Silva WMB,de Oliveira Pinheiro S,Alves DR,de Menezes JESA,Magalhães FEA,Silva FCO,Silva J,Marinho ES,de Morais SM

    更新日期:2020-04-01 00:00:00

  • The novel free radical scavenger, edaravone, increases neural stem cell number around the area of damage following rat traumatic brain injury.

    abstract::Edaravone is a novel free radical scavenger that is clinically employed in patients with acute cerebral infarction, but has not previously been used to treat traumatic brain injury (TBI). In this study, we investigated the effect of edaravone administration on rat TBI. In particular, we used immunohistochemistry to mo...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Itoh T,Satou T,Nishida S,Tsubaki M,Hashimoto S,Ito H

    更新日期:2009-11-01 00:00:00

  • Melamine Alters Glutamatergic Synaptic Transmission of CA3-CA1 Synapses Presynaptically Through Autophagy Activation in the Rat Hippocampus.

    abstract::Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Zhang H,Wang H,Xiao X,Zhang T

    更新日期:2016-01-01 00:00:00

  • Dopamine and incentive learning: a framework for considering antipsychotic medication effects.

    abstract::Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Beninger RJ

    更新日期:2006-12-01 00:00:00

  • 1MeTIQ provides protection against Aβ-induced reduction of surface expression of synaptic proteins and inhibits H₂O₂-induced oxidative stress in primary hippocampal neurons.

    abstract::Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Kuszczyk MA,Sadowski MJ,Antkiewicz-Michaluk L,Lazarewicz JW

    更新日期:2014-05-01 00:00:00

  • IDRD2 TaqIA polymorphism is associated with urinary homovanillic acid levels in a sample of Spanish male alcoholic patients.

    abstract::The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Ponce G,Hoenicka J,Rodríguez-Jiménez R,Gozalo A,Jimenéz M,Monasor R,Aragüés M,Rubio G,Jiménez-Arriero MA,Ramos JA,Palomo T

    更新日期:2004-01-01 00:00:00

  • Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.

    abstract::Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Huang CW,Cheng JT,Tsai JJ,Wu SN,Huang CC

    更新日期:2009-01-01 00:00:00

  • Effect of Combined Prenatal and Adult Benzophenone-3 Dermal Exposure on Factors Regulating Neurodegenerative Processes, Blood Hormone Levels, and Hematological Parameters in Female Rats.

    abstract::Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

    更新日期:2020-03-01 00:00:00

  • Ethylmalonic acid induces permeability transition in isolated brain mitochondria.

    abstract::Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Cecatto C,Amaral AU,Leipnitz G,Castilho RF,Wajner M

    更新日期:2014-08-01 00:00:00

  • Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.

    abstract::This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

    journal_title:Neurotoxicity research

    pub_type: 评论,杂志文章


    authors: Hansen B

    更新日期:2020-01-01 00:00:00

  • Effects of DSP4 on the noradrenergic phenotypes and its potential molecular mechanisms in SH-SY5Y cells.

    abstract::Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Wang Y,Musich PR,Serrano MA,Zou Y,Zhang J,Zhu MY

    更新日期:2014-02-01 00:00:00

  • Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice.

    abstract::Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Kulikova AA,Cheglakov IB,Kukharsky MS,Ovchinnikov RK,Kozin SA,Makarov AA

    更新日期:2016-05-01 00:00:00

  • Role of endocannabinoid system in mental diseases.

    abstract::In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

    journal_title:Neurotoxicity research

    pub_type: 历史文章,杂志文章,评审


    authors: Manzanares J,Urigüen L,Rubio G,Palomo T

    更新日期:2004-01-01 00:00:00

  • Spreading of Pathology in Alzheimer's Disease.

    abstract::The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Lv ZY,Tan CC,Yu JT,Tan L

    更新日期:2017-11-01 00:00:00

  • Functional analysis of histone demethylase Jmjd2b on lipopolysaccharide-treated murine neural stem cells (NSCs).

    abstract::Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Das ND,Choi MR,Jung KH,Park JH,Lee HT,Das A,Kim SH,Chai YG

    更新日期:2013-02-01 00:00:00

  • MPTP-induced apoptosis in the retina of goldfish.

    abstract::Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Villani L,Beraudi A,Giuliani A,Poli A

    更新日期:2001-07-01 00:00:00

  • Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

    abstract::Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Thakur V,Jamwal S,Kumar M,Rahi V,Kumar P

    更新日期:2020-08-01 00:00:00

  • Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release.

    abstract::1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Antkiewicz-Michaluk L,Wąsik A,Romańska I,Bojarski A,Michaluk J

    更新日期:2011-08-01 00:00:00

  • Glial cell dysregulation: a new perspective on Alzheimer disease.

    abstract::Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: von Bernhardi R

    更新日期:2007-12-01 00:00:00

  • Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.

    abstract::Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Kostrzewa RM,Segura-Aguilar J

    更新日期:2003-01-01 00:00:00

  • A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs.

    abstract::The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Sadakierska-Chudy A,Filip M

    更新日期:2015-02-01 00:00:00

  • Correction to: Comparing the Neuroprotective Effects of Caffeic Acid in Rat Cortical Slices and Caenorhabditis elegans: Involvement of Nrf2 and SKN-1 Signaling Pathways.

    abstract::One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,已发布勘误


    authors: Colonnello A,Aguilera-Portillo G,Rubio-López LC,Robles-Bañuelos B,Rangel-López E,Cortez-Núñez S,Evaristo-Priego Y,Silva-Palacios A,Galván-Arzate S,García-Contreras R,Túnez I,Chen P,Aschner M,Santamaría A

    更新日期:2020-03-01 00:00:00

  • Effect of chronic and subchronic organic solvents exposure on balance control of workers in plant manufacturing adhesive materials.

    abstract::High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Herpin G,Gargouri I,Gauchard GC,Nisse C,Khadhraoui M,Elleuch B,Zmirou-Navier D,Perrin PP

    更新日期:2009-02-01 00:00:00

  • Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review.

    abstract::Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Boldyrev A,Bulygina E,Makhro A

    更新日期:2004-01-01 00:00:00

  • Aberrant CpG Methylation Mediates Abnormal Transcription of MAO-A Induced by Acute and Chronic L-3,4-Dihydroxyphenylalanine Administration in SH-SY5Y Neuronal Cells.

    abstract::L-3,4-dihydroxyphenylalanine (L-dopa) remains the most effective drug for therapy of Parkinson's disease (PD); however, long-term use of it causes serious side effects. L-dopa-induced dyskinesia (LID) has consistently been related to L-dopa-derived excessive dopamine release, but the mechanisms have not been addressed...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Yang Z,Wang X,Yang J,Sun M,Wang Y,Wang X

    更新日期:2017-04-01 00:00:00

  • Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed in Alzheimer's Disease.

    abstract::Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: Yu ZY,Li WW,Yang HM,Mañucat-Tan NB,Wang J,Wang YR,Sun BL,Hu ZC,Zhang LL,Tan L,Deng J,Liu YH

    更新日期:2020-04-01 00:00:00

  • Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章


    authors: K C S,Kakoty V,Marathe S,Chitkara D,Taliyan R

    更新日期:2020-07-18 00:00:00

  • Quality Control in Huntington's Disease: a Therapeutic Target.

    abstract::Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

    journal_title:Neurotoxicity research

    pub_type: 杂志文章,评审


    authors: Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

    更新日期:2019-10-01 00:00:00