Abstract：
:Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways, and data availability. In this work, we develop phycocyanin concentration (i.e., CHAB exposure) maps using satellite remote sensing across northern New England to assess relationships with ALS cases using a spatial epidemiological approach. Strategic semi-analytical regression models integrated Landsat and in situ observations to map phycocyanin concentration (PC) for all lakes greater than 8 ha (n = 4117) across the region. Then, systematic versions of a Bayesian Poisson Log-linear model were fit to assess the mapped PC as a risk factor for ALS while accounting for model uncertainty and modifiable area unit problems. The satellite remote sensing of PC had strong overall ability to map conditions (adj. R2, 0.86; RMSE, 11.92) and spatial variability across the region. PC tended to be positively associated with ALS risk with the level of significance depending on fixed model components. Meta-analysis shows that when average PC exposure is 100 μg/L, an all model average odds ratio is 1.48, meaning there is about a 48% increase in average ALS risk. This research generated the first regionally comprehensive map of PC for thousands of lakes and integrated robust spatial uncertainty. The outcomes support the hypothesis that cyanotoxins increase the risk of ALS, which helps our understanding of the etiology of ALS.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Torbick N,Ziniti B,Stommel E,Linder E,Andrew A,Caller T,Haney J,Bradley W,Henegan PL,Shi Xdoi
10.1007/s12640-017-9740-ysubject
Has Abstractpub_date
2018-01-01 00:00:00pages
199-212issue
1eissn
1029-8428issn
1476-3524pii
10.1007/s12640-017-9740-yjournal_volume
33pub_type
杂志文章abstract：:We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00064-4
更新日期：2019-10-01 00:00:00
abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9503-y
更新日期：2015-04-01 00:00:00
abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033861
更新日期：2008-12-01 00:00:00
abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033166
更新日期：2003-01-01 00:00:00
abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9421-4
更新日期：2014-02-01 00:00:00
abstract：:MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingeste...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9831-9
更新日期：2018-04-01 00:00:00
abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033804
更新日期：2008-10-01 00:00:00
abstract：:Methamphetamine (METH) is a psychostimulant that damages nigrostriatal dopaminergic terminals, primarily by enhancing dopamine and glutamate release. α₁-adrenergic receptor (AR) subtype involved in METH-induced neurotoxicity in rats was investigated using selective α₁-AR antagonists. METH neurotoxicity was evaluated b...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9369-9
更新日期：2013-08-01 00:00:00
abstract：:Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9570-8
更新日期：2016-01-01 00:00:00
abstract：:The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...
journal_title：Neurotoxicity research
pub_type： 已发布勘误
doi：10.1007/s12640-018-9982-3
更新日期：2019-05-01 00:00:00
abstract：:Depression is a worldwide problem with a great social and economic burden in many countries. In our previous research, we found that the expression of proBDNF/p75NTR/sortilin is upregulated in patients with major depressive disorder. In addition, the treatment of proBDNF antibodies reversed both the depressive behavio...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00101-2
更新日期：2020-01-01 00:00:00
abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9018-0
更新日期：2009-02-01 00:00:00
abstract：:Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9460-5
更新日期：2014-08-01 00:00:00
abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9836-4
更新日期：2018-05-01 00:00:00
abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9321-z
更新日期：2013-01-01 00:00:00
abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9508-6
更新日期：2015-02-01 00:00:00
abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9451-y
更新日期：2014-07-01 00:00:00
abstract：:There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9468-x
更新日期：2014-10-01 00:00:00
abstract：:Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross blood brain barrier and received considerable attention for its neuroprotective role. We have reported the benefit of AA against aluminum chloride (AlCl3)-induced amyloid pathology, enhanced acetylcholine esterase (AChE) act...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-9999-2
更新日期：2019-05-01 00:00:00
abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9611-y
更新日期：2016-08-01 00:00:00
abstract：:The TaqIA1 allele of the dopamine receptor gene D2 (DRD2) has been associated with alcoholism, as well as with other addictive behaviours. The exact nature of how the presence of this allele can be a vulnerability factor in the development of alcoholism remains unclear. In this study we found that the presence in the ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033311
更新日期：2004-01-01 00:00:00
abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9049-6
更新日期：2009-07-01 00:00:00
abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9125-y
更新日期：2010-05-01 00:00:00
abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9542-z
更新日期：2015-10-01 00:00:00
abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033979
更新日期：2005-11-01 00:00:00
abstract：:Alzheimer's disease (AD) is associated with increased brain levels of β-amyloid (Aβ) peptides, which readily self-aggregate into fibrils and oligomers that have particularly deleterious properties toward synapses of excitatory glutamatergic neurons. Here, we examined the neuroprotective effects of 1-methyl-1,2,3,4,-te...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9440-1
更新日期：2014-05-01 00:00:00
abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9874-6
更新日期：2018-04-01 00:00:00
abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033824
更新日期：2005-10-01 00:00:00
abstract：:Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00054-6
更新日期：2019-08-01 00:00:00
abstract：:Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00091-1
更新日期：2019-10-01 00:00:00
