Antidepressant Drugs Correct the Imbalance Between proBDNF/p75NTR/Sortilin and Mature BDNF/TrkB in the Brain of Mice with Chronic Stress.

abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...

journal_title：Neurotoxicity research

authors： von Bernhardi R

更新日期：2007-12-01 00:00:00

abstract：:Effects of chemotherapeutics on glioma cell lines and spheroids are usually investigated without evaluating the effects of chemotherapeutics on normal brain tissue. To perform such investigations, the aim of this study was to establish a panel of markers for detection of general cell death and more specific neuronal a...

journal_title：Neurotoxicity research

authors： Nørregaard A,Jensen SS,Kolenda J,Aaberg-Jessen C,Christensen KG,Jensen PH,Schrøder HD,Kristensen BW

更新日期：2012-07-01 00:00:00

abstract：:Inflammation can cause memory impairment. In the present study, the effect of carvacrol on brain tissue inflammation and oxidative stress as well as learning and memory in lipopolysaccharide (LPS)-challenged rats was evaluated. The animals were grouped and treated: (1) control which received vehicle instead of LPS and...

journal_title：Neurotoxicity research

authors： Hakimi Z,Salmani H,Marefati N,Arab Z,Gholamnezhad Z,Beheshti F,Shafei MN,Hosseini M

更新日期：2020-04-01 00:00:00

abstract：:Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk betwee...

journal_title：Neurotoxicity research

authors： Falcão AS,Silva RF,Vaz AR,Gomes C,Fernandes A,Barateiro A,Tiribelli C,Brites D

更新日期：2014-07-01 00:00:00

abstract：:The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...

journal_title：Neurotoxicity research

authors： Lau WK,Mak JC,Chan KH,Law AC

更新日期：2012-08-01 00:00:00

abstract：:Aluminum-induced neuronal injury has been implicated in various neurodegenerative disorders. However, the underlying mechanism involved in this pathogenesis still remains unknown. Our present findings demonstrated that chronic aluminum exposure resulted in spatial learning impairment and significantly increased intrac...

journal_title：Neurotoxicity research

authors： Wang B,Zhao J,Yu M,Meng X,Cui X,Zhao Y,Zhu Y,Xing W,Guan Y

更新日期：2014-07-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...

journal_title：Neurotoxicity research

authors： Eriksson P,Ankarberg E,Viberg H,Fredriksson A

更新日期：2001-01-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...

journal_title：Neurotoxicity research

authors： Maes M,Sirivichayakul S,Kanchanatawan B,Vodjani A

更新日期：2019-08-01 00:00:00

abstract：:The cytotoxic effects of methamphetamine (MA) are well established to be caused via induced oxidative stress which in turn compromises the core function of the blood-brain barrier (BBB) by reducing its ability to regulate the homeostatic environment of the brain. While most studies were conducted over a period of 24-4...

journal_title：Neurotoxicity research

authors： Fisher D,Gamieldien K,Mafunda PS

更新日期：2015-07-01 00:00:00

abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...

journal_title：Neurotoxicity research

authors： Fernandez LL,de Lima MN,Scalco F,Vedana G,Miwa C,Hilbig A,Vianna M,Schröder N

更新日期：2011-08-01 00:00:00

abstract：:Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...

journal_title：Neurotoxicity research

authors： Huang CW,Cheng JT,Tsai JJ,Wu SN,Huang CC

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...

journal_title：Neurotoxicity research

authors： Lei H,Zhang Y,Huang L,Xu S,Li J,Yang L,Wang L,Xing C,Wang X,Peng Y

更新日期：2018-10-01 00:00:00

abstract：:One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...

journal_title：Neurotoxicity research

authors： Colonnello A,Aguilera-Portillo G,Rubio-López LC,Robles-Bañuelos B,Rangel-López E,Cortez-Núñez S,Evaristo-Priego Y,Silva-Palacios A,Galván-Arzate S,García-Contreras R,Túnez I,Chen P,Aschner M,Santamaría A

更新日期：2020-03-01 00:00:00

abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...

journal_title：Neurotoxicity research

authors： Herpin G,Gargouri I,Gauchard GC,Nisse C,Khadhraoui M,Elleuch B,Zmirou-Navier D,Perrin PP

更新日期：2009-02-01 00:00:00

abstract：:Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In...

journal_title：Neurotoxicity research

authors： Borroto-Escuela DO,Romero-Fernandez W,Wydra K,Zhou Z,Suder A,Filip M,Fuxe K

更新日期：2020-02-01 00:00:00

abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

journal_title：Neurotoxicity research

authors： de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

更新日期：2019-10-01 00:00:00

abstract：:Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...

journal_title：Neurotoxicity research

authors： Nascimento GC,Bariotto-Dos-Santos K,Leite-Panissi CRA,Del-Bel EA,Bortolanza M

更新日期：2018-11-01 00:00:00

abstract：:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication mod...

journal_title：Neurotoxicity research

authors： Hansen B

更新日期：2020-01-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Kostrzewa JP,Brown RW,Nowak P,Brus R

更新日期：2008-10-01 00:00:00

abstract：:MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingeste...

journal_title：Neurotoxicity research

authors： Górska AM,Kamińska K,Wawrzczak-Bargieła A,Costa G,Morelli M,Przewłocki R,Kreiner G,Gołembiowska K

更新日期：2018-04-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...

journal_title：Neurotoxicity research

authors： Lameth J,Gervais A,Colin C,Lévêque P,Jay TM,Edeline JM,Mallat M

更新日期：2017-10-01 00:00:00

abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...

journal_title：Neurotoxicity research

authors： Kostrzewa RM,Segura-Aguilar J

更新日期：2003-01-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...

journal_title：Neurotoxicity research

authors： Ślusarczyk J,Piotrowski M,Szczepanowicz K,Regulska M,Leśkiewicz M,Warszyński P,Budziszewska B,Lasoń W,Basta-Kaim A

更新日期：2016-11-01 00:00:00

abstract：:Neuronal cell death caused by pathophysiological over-activation of glutamate receptors and the subsequent CaII overloading, has been implicated in neurodegeneration after stroke, cerebral trauma and epileptic seizures. Recent findings suggest that certain progesterone metabolites (neurosteroids) such as allopregnanol...

journal_title：Neurotoxicity research

authors： Xilouri M,Papazafiri P

更新日期：2008-05-01 00:00:00

abstract：:Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...

journal_title：Neurotoxicity research

authors： Echeverry C,Arredondo F,Martínez M,Abin-Carriquiry JA,Midiwo J,Dajas F

更新日期：2015-01-01 00:00:00