Abstract:
:MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingested with caffeine. Caffeine as a non-selective adenosine A1/A2A receptor antagonist affects dopaminergic and serotonergic transmissions. The aim of the present study was to determine the changes in DA and 5-HT release in the mouse striatum induced by MDMA and caffeine after their chronic administration. To find out whether caffeine aggravates MDMA neurotoxicity, the content of DA and 5-HT, density of brain DAT and SERT, and oxidative damage of nuclear DNA were determined. Furthermore, the effect of caffeine on MDMA-induced changes in striatal dynorphin and enkephalin and on behavior was assessed. The DA and 5-HT release was determined with in vivo microdialysis, and the monoamine contents were measured by HPLC with electrochemical detection. DNA damage was assayed with the alkaline comet assay. DAT and SERT densities were determined by immunohistochemistry, while prodynorphin (PDYN) and proenkephalin were determined by quantitative PCR reactions. The behavioral changes were measured by the open-field (OF) test and novel object recognition (NOR) test. Caffeine potentiated MDMA-induced DA release while inhibiting 5-HT release in the mouse striatum. Caffeine also exacerbated the oxidative damage of nuclear DNA induced by MDMA but diminished DAT decrease in the striatum and worsened a decrease in SERT density produced by MDMA in the frontal cortex. Neither the striatal PDYN expression, increased by MDMA, nor exploratory and locomotor activities of mice, decreased by MDMA, were affected by caffeine. The exploration of novel object in the NOR test was diminished by MDMA and caffeine. Our data provide evidence that long-term caffeine administration has a powerful influence on functions of dopaminergic and serotonergic neurons in the mouse brain and on neurotoxic effects evoked by MDMA.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Górska AM,Kamińska K,Wawrzczak-Bargieła A,Costa G,Morelli M,Przewłocki R,Kreiner G,Gołembiowska Kdoi
10.1007/s12640-017-9831-9subject
Has Abstractpub_date
2018-04-01 00:00:00pages
532-548issue
3eissn
1029-8428issn
1476-3524pii
10.1007/s12640-017-9831-9journal_volume
33pub_type
杂志文章abstract::Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-018-9912-4
更新日期:2018-11-01 00:00:00
abstract::Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033380
更新日期:2003-01-01 00:00:00
abstract::Predominant accumulation of ethylmalonic acid (EMA) in tissues and biological fluids is a characteristic of patients affected by short chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy. Neurological abnormalities are frequently found in these disorders, but the mechanisms underlying the brain inj...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9460-5
更新日期:2014-08-01 00:00:00
abstract::The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism, i.e., labile, reduced sulfur (LS) in the rat plasma. The above-mentioned parameters were determined after i.p. acute ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9403-6
更新日期:2013-10-01 00:00:00
abstract::Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotrans...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033568
更新日期:2007-04-01 00:00:00
abstract::Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9756-3
更新日期:2017-10-01 00:00:00
abstract::Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033357
更新日期:2006-12-01 00:00:00
abstract::Parkinson's disease (PD) is the second most familiar, progressive and movement-related neurodegenerative disorder after Alzheimer disease. This study aimed to decipher the role of autophagy in cypermethrin-induced Parkinsonism, an animal model of PD. Indicators of autophagy [expression of beclin 1, autophagy-related p...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9800-3
更新日期:2018-02-01 00:00:00
abstract::Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033454
更新日期:2004-01-01 00:00:00
abstract::Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. A sublethal preconditioning has been proposed as a neuroprotective strategy against several central nervous system neurodegenerative diseases. We have recently demonstrated that autophagy is a pr...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9390-7
更新日期:2013-11-01 00:00:00
abstract::Chronic alcohol consumption may cause neurodevelopmental and neurodegenerative disorders. Alcohol neurotoxicity is associated with the production of acetaldehyde and reactive oxygen species that induce oxidative DNA damage. However, the molecular mechanisms by which ethanol disturbs the DNA damage response (DDR), resu...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9554-8
更新日期:2016-01-01 00:00:00
abstract::Maillard reactions have been explored by food chemists for many years. It is only recently that the advanced glycation end products (AGEs), the end products of the Maillard reaction, have been detected in a wide variety of diseases such as diabetes, atherosclerosis, cataractogenesis, Parkinson disease and Alzheimer di...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/1029840290007321
更新日期:2002-05-01 00:00:00
abstract::Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033301
更新日期:2004-01-01 00:00:00
abstract::Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033205
更新日期:2001-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00258-1
更新日期:2020-07-18 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9049-6
更新日期:2009-07-01 00:00:00
abstract::One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12640-019-00153-4
更新日期:2020-03-01 00:00:00
abstract::Organophosphate (OP) poisoning is associated with long-lasting neurological damage, which is attributed mainly to the excessive levels of glutamate caused by the intoxication. Glutamate toxicity, however, is not specific to OP poisoning, and is linked to propagation of damage in both acute and chronic neurodegenerativ...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-013-9388-1
更新日期:2013-08-01 00:00:00
abstract::The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033824
更新日期:2005-10-01 00:00:00
abstract::Botulinum neurotoxin (BoNT) has been used clinically since 1980, with an ever-increasing range of clinical applications. This has coincided with a period of massively expanded interest in the underlying biology of the neurotoxin. Tremendous advances have taken place in the scientific understanding of neurotoxin struct...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033931
更新日期:2006-04-01 00:00:00
abstract::Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00054-6
更新日期:2019-08-01 00:00:00
abstract::The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9244-0
更新日期:2011-11-01 00:00:00
abstract::1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is present in the human and rodent brain as a mixture of stereospecific (R)- and (S)-1MeTIQ enantiomers. The racemate, (R,S)-1MeTIQ, exhibits neuroprotective activity as shown in the earlier study by the authors, and In addition, it was suggested to play a crucial physi...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9228-5
更新日期:2011-08-01 00:00:00
abstract::Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-011-9251-1
更新日期:2012-02-01 00:00:00
abstract::Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-016-9652-2
更新日期:2016-11-01 00:00:00
abstract::The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290007592
更新日期:2002-02-01 00:00:00
abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00154-3
更新日期:2020-03-01 00:00:00
abstract::The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033979
更新日期:2005-11-01 00:00:00
abstract::The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-019-00051-9
更新日期:2019-11-01 00:00:00
abstract::Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00021-1
更新日期:2019-11-01 00:00:00