Abstract：
:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system, ROS levels are under control of ionotropic and metabotropic glutamate receptors, which modulate ion fluxes through the neuronal membrane. The Na+/K(+)-pump is also one of the important participants affecting stationary ROS levels through several distinct mechanisms. This review describes the involvement of the Na+/K(+)-pump in intracellular signaling mechanisms via cross-talk between the pump and glutamate receptors in cerebellum granule cells. Selective dysfunction of mGlu II receptors may also lead to abnormal protein phosphorylation (i.e., tau phosphorylation), culminating in neurodegenerative disorders (i.e., Alzheimer disease). Also, unregulated production of intracellular ROS resulting from an imbalance of ionotropic and metabotropic receptors may activate one or more protein kinases. In summary, Glu receptor dysfunction, leading to a deficit in glutamate-mediated signal transduction may represent one of the earliest stages of neurodegenerative disorders. The Na+/K(+)-pump is able to prevent over-production of intracellular ROS, thus increasing oxidative stability of neuronal cells.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Boldyrev A,Bulygina E,Makhro Adoi
10.1007/BF03033454keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
581-7issue
7-8eissn
1029-8428issn
1476-3524journal_volume
6pub_type
杂志文章,评审abstract：:Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NE...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9421-4
更新日期：2014-02-01 00:00:00
abstract：:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00142-7
更新日期：2020-04-01 00:00:00
abstract：:The possible link between tau phosphorylation and tau assembly in these neurodegenerative diseases known as tauopathies is described. Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033284
更新日期：2004-01-01 00:00:00
abstract：:Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033913
更新日期：2007-10-01 00:00:00
abstract：:One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12640-019-00153-4
更新日期：2020-03-01 00:00:00
abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9905-3
更新日期：2018-10-01 00:00:00
abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033380
更新日期：2003-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033367
更新日期：2008-01-01 00:00:00
abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033291
更新日期：2004-01-01 00:00:00
abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9500-1
更新日期：2015-04-01 00:00:00
abstract：:The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuro...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9566-4
更新日期：2016-01-01 00:00:00
abstract：:Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-010-9163-5
更新日期：2010-11-01 00:00:00
abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9872-8
更新日期：2018-08-01 00:00:00
abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9125-y
更新日期：2010-05-01 00:00:00
abstract：:Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9346-3
更新日期：2013-02-01 00:00:00
abstract：:The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9495-7
更新日期：2015-02-01 00:00:00
abstract：:Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00154-3
更新日期：2020-03-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9556-6
更新日期：2016-04-01 00:00:00
abstract：:Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00118-7
更新日期：2020-02-01 00:00:00
abstract：:Reward-related incentive learning involves the acquisition by neutral stimuli of an enhanced ability to elicit approach and other responses. Previous studies have shown that both dopamine (DA) and glutamate (Glu) play critical roles in this type of learning. Signaling molecules are intracellular messengers that partic...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033301
更新日期：2004-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain. Member of the peroxisome proliferato...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00258-1
更新日期：2020-07-18 00:00:00
abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9321-z
更新日期：2013-01-01 00:00:00
abstract：:Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-0007-7
更新日期：2019-04-01 00:00:00
abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033979
更新日期：2005-11-01 00:00:00
abstract：:Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033484
更新日期：2007-01-01 00:00:00
abstract：:The complexity of the genome is regulated by epigenetic mechanisms, which act on the level of DNA, histones, and nucleosomes. Epigenetic machinery is involved in various biological processes, including embryonic development, cell differentiation, neurogenesis, and adult cell renewal. In the last few years, it has beco...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9508-6
更新日期：2015-02-01 00:00:00
abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9054-9
更新日期：2009-10-01 00:00:00
abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9611-y
更新日期：2016-08-01 00:00:00
abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033901
更新日期：2007-07-01 00:00:00
abstract：:MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingeste...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9831-9
更新日期：2018-04-01 00:00:00
