Abstract：
:Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotransmitter signalling and may thereby provide one mechanism underlying neurological abnormalities. Glutamate is the main excitatory neurotransmitter in the mammalian central nervous system and mediates neurotransmission across most excitatory synapses. In this article we review the timely expression of the excitatory neurotransmitter glutamate and its receptors during brain development, briefly review glutamate receptor antagonists and present clinical and experimental evidence describing their adverse effects in the developing brain.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Kaindl AM,Ikonomidou Cdoi
10.1007/BF03033568subject
Has Abstractpub_date
2007-04-01 00:00:00pages
203-18issue
3-4eissn
1029-8428issn
1476-3524journal_volume
11pub_type
杂志文章,评审abstract：:Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9346-3
更新日期：2013-02-01 00:00:00
abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-0009-5
更新日期：2019-05-01 00:00:00
abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9063-8
更新日期：2009-08-01 00:00:00
abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9500-1
更新日期：2015-04-01 00:00:00
abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9652-2
更新日期：2016-11-01 00:00:00
abstract：:Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00154-3
更新日期：2020-03-01 00:00:00
abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00017-x
更新日期：2019-07-01 00:00:00
abstract：:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9603-y
更新日期：2016-05-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9556-6
更新日期：2016-04-01 00:00:00
abstract：:Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9896-0
更新日期：2018-11-01 00:00:00
abstract：:Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic dec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00091-1
更新日期：2019-10-01 00:00:00
abstract：:The mitochondrial toxin, 3-nitropropionic acid (3-NP), produces motor dysfunction and striatal atrophy in rats. However, rat strain and method of administration may contribute to variability in the deficits caused by 3-NP toxicity. To evaluate this, changes in nocturnal spontaneous locomotor activity from chronic admi...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033979
更新日期：2005-11-01 00:00:00
abstract：:Epileptic seizures in diabetic hyperglycemia (DH) are not uncommon. This study aimed to determine the acute behavioral, pathological, and electrophysiological effects of status epilepticus (SE) on diabetic animals. Adult male Sprague-Dawley rats were first divided into groups with and without streptozotocin (STZ)-indu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9008-2
更新日期：2009-01-01 00:00:00
abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033861
更新日期：2008-12-01 00:00:00
abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9503-y
更新日期：2015-04-01 00:00:00
abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9165-3
更新日期：2011-02-01 00:00:00
abstract：:In the slowly progressive neurodegenerative disorders like Parkinson's disease and Alzheimer's disease very different neuronal populations undergo degenerative processes, although the cascades of cellular events leading to death are supposed to be similar. We suggest that the complex pattern of degeneration in Parkins...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033793
更新日期：2000-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033367
更新日期：2008-01-01 00:00:00
abstract：:Neurotrophins are initially synthesized as precursor forms that are cleaved to release C-terminal mature forms that bind to Trk receptors to initiate survival and differentiative responses. Recent studies suggest that the precursor form of NGF (proNGF) acts as a distinct ligand by binding to a receptor complex of p75 ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9054-9
更新日期：2009-10-01 00:00:00
abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9836-4
更新日期：2018-05-01 00:00:00
abstract：:Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9180-4
更新日期：2011-04-01 00:00:00
abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033205
更新日期：2001-10-01 00:00:00
abstract：:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9754-5
更新日期：2017-10-01 00:00:00
abstract：:The author group has previously established an in vivo subchronic cigarette smoke (CS) exposure rat model, in which the systemic oxidative burden as well as the modulation of local anti-oxidative enzymes in the lung has been demonstrated. Oxidative stress has been shown to induce pro-inflammatory cytokine release, inc...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9301-8
更新日期：2012-08-01 00:00:00
abstract：:Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9696-3
更新日期：2017-05-01 00:00:00
abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9043-z
更新日期：2009-05-01 00:00:00
abstract：:One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,已发布勘误
doi：10.1007/s12640-019-00153-4
更新日期：2020-03-01 00:00:00
abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...
journal_title：Neurotoxicity research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s12640-009-9092-3
更新日期：2009-11-01 00:00:00
