Abstract：
:Neural stem cell (NSC) neurogenesis is the formation of new neurons by which the brain maintains its lifelong plasticity in response to extrinsic and intrinsic changes. Here, we show the effect of lipopolysaccharides (LPS) as an in vitro model of inflammation on NSCs to determine whether the inflammatory mediators can epigenetically affect NSCs and alter their proliferation and differentiation abilities. To study the effect of LPS on NSCs, we used an immortalized mouse neuroectodermal stem cell line, NE-4C. We found that Jmjd2b, histone-3 lysine-9 di-/tri-methyl (H3K9me2/3) demethylase, is functional following LPS treatment and is crucial in multiple signaling pathways and biological processes. The global gene expression levels were detected in Jmjd2b-knockdown (kd) NE-4C cells and in LPS-stimulated Jmjd2b-kd NE-4C cells using an Affymetrix GeneChip(®) Mouse Gene 1.0 ST Array. In addition, the datasets were analyzed using MetaCore Pathway Analysis (GeneGo). The attenuation of Jmjd2b in NE-4C cells significantly affected the p65, iNOS, Bcl2, and TGF-β expression levels and had downstream effects on related signaling pathways. In addition, chromatin immunoprecipitation revealed that Jmjd2b-kd could inhibit the Notch1, IL-1β, and IL-2 genes by recruiting repressive H3K9me3 to their promoters. Moreover, this study highlights Jmjd2b role in LPS-mediated inflammation, which suggests an epigenetic regulation in NE-4C cells. Finally, this study establishes novel Jmjd2b targets that potentiate a biological rationale involving Jmjd2b in NSC inflammation.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Das ND,Choi MR,Jung KH,Park JH,Lee HT,Das A,Kim SH,Chai YGdoi
10.1007/s12640-012-9346-3subject
Has Abstractpub_date
2013-02-01 00:00:00pages
154-65issue
2eissn
1029-8428issn
1476-3524journal_volume
23pub_type
杂志文章abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033166
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
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