Abstract:
:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amyloidosis. In vitro studies have shown that isomerization of Asp7 promotes zinc-induced oligomerization of the Aβ metal-binding domain (Aβ1-16). Here we report that single intracerebral injection of the peptide Aβ1-16 with isomerized Asp7 (isoAβ1-16) but not the injection of Aβ1-16 significantly increases amyloid burden in 5XFAD transgenic mice. Our results provide evidence for a role of isoAβ1-16 as a minimal seeding agent of Aβ aggregation in vivo.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Kulikova AA,Cheglakov IB,Kukharsky MS,Ovchinnikov RK,Kozin SA,Makarov AAdoi
10.1007/s12640-016-9603-ysubject
Has Abstractpub_date
2016-05-01 00:00:00pages
551-7issue
4eissn
1029-8428issn
1476-3524pii
10.1007/s12640-016-9603-yjournal_volume
29pub_type
杂志文章abstract::Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...
journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/s12640-019-00030-0
更新日期:2019-07-01 00:00:00
abstract::Cocaine was previously shown to act at the Sigma1R which is a target for counteracting cocaine actions. It therefore becomes of interest to test if the monoamine stabilizer (-) OSU-6162 (OSU-6162) with a nanomolar affinity for the Sigma1R can acutely modulate in low doses the effects of cocaine self-administration. In...
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abstract:BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...
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doi:10.1007/s12640-015-9578-0
更新日期:2016-02-01 00:00:00
abstract::The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...
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更新日期:2020-12-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9787-9
更新日期:2018-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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更新日期:2017-10-01 00:00:00
abstract::Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033334
更新日期:2006-08-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-012-9321-z
更新日期:2013-01-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/BF03033793
更新日期:2000-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033778
更新日期:2005-01-01 00:00:00
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journal_title:Neurotoxicity research
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doi:10.1007/BF03033504
更新日期:2008-05-01 00:00:00
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journal_title:Neurotoxicity research
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更新日期:2013-11-01 00:00:00
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更新日期:2007-07-01 00:00:00
abstract::Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...
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pub_type: 杂志文章,评审
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更新日期:2007-12-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9312-0
更新日期:2012-11-01 00:00:00
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doi:10.1007/BF03033380
更新日期:2003-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:Neurotoxicity research
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