Abstract：
:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences of the exposures in affecting hippocampus-depended cognition and synaptic plasticity. Wistar rats were exposed to melamine through the whole gestational period or from postnatal day (PD) 21 to PD41, and then tested on PD90. The experiments of water maze and hippocampal synaptic plasticity in vivo were performed to assess the effects on spatial cognition and synaptic impairments. The results indicated that cognitive defects were induced by exposures to either prenatal or postnatal melamine, whereas there was a more serious damage in prenatal. Histological evidence further showed that there were the detrimental effects of both prenatal and postnatal effects. Paired-pulse facilitation ratio and post-tetanic potentiation were severely impacted in prenatal-exposed rats but not postnatal-exposed ones. Both exposures to prenatal and postnatal melamine impaired long-term potentiation, while there was severe damage to prenatal animals. These data suggest that the detrimental effects of prenatal and postnatal melamine on cognition and hippocampal synaptic plasticity could persist into adulthood, and the impairment of prenatal exposure was to some extent more severe. Hence, prenatal and postnatal exposures to melamine may have different effects on hippocampus-dependent learning and memory, which would most likely result from differentially adversely properties on the hippocampal CA1 synaptic function.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
An L,Zhang Tdoi
10.1007/s12640-015-9578-0subject
Has Abstractpub_date
2016-02-01 00:00:00pages
218-29issue
2eissn
1029-8428issn
1476-3524pii
10.1007/s12640-015-9578-0journal_volume
29pub_type
杂志文章abstract：:Cellular mechanisms involved in neurodegeneration and neuroprotection are continuing to be explored, and this paper focuses on some novel discoveries that give further insight into these processes. Oligodendrocytes and activated astroglia are likely generators of the pro-inflammatory cytokines, such as the tumor necro...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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