Abstract:
:Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-DSM IV), born from 1983-1998, that presented to the Genetic Centers of America for outpatient genetic evaluations were prospectively examined for urinary prophryin levels (LabCorp, Inc.) from June 2005-June 2006. Imaging and laboratory testing were conducted on each patient to rule-out other causal factors for their ASDs. As controls, age-, sex-, and race-matched neurotypical ASD siblings were examined. An apparent dose-response effect was observed between autism severity and increased urinary coproporphyrins. Patients with non-chelated autism (2.25-fold, 83% had levels > 2 SD above the control mean) and non-chelated ASDs (2-fold, 58% had levels > 2 SD above the control mean), but not patients with non-chelated pervasive developmental delay-not otherwise specified (PDD-NOS) or Asperger's disorder (1.4-fold, 46% had levels > 2 SD above the control mean), had significantly increased median coproporphyrin levels versus controls. A significant increase (1.7-fold) in median coproporphyrin levels was observed among non-chelated ASD patients versus chelated ASD patients. Porphyrins should be routinely clinically measured in ASDs, and potential ASD treatments should consider monitoring porphyrin levels. Additional research should be conducted to evaluate the potential role for mercury exposure in some ASDs.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Geier DA,Geier MRdoi
10.1007/BF03033334subject
Has Abstractpub_date
2006-08-01 00:00:00pages
57-64issue
1eissn
1029-8428issn
1476-3524journal_volume
10pub_type
杂志文章abstract::Few studies have been undertaken on the relationship of the structure of flavones and neuroprotection. Previously, we described the structural determinants of the neuroprotective activity of some natural flavones in cerebellar granule neurons in culture against an oxidative insult (H2O2). In the present work, we analy...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-014-9483-y
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abstract::In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...
journal_title:Neurotoxicity research
pub_type: 历史文章,杂志文章,评审
doi:10.1007/BF03033223
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abstract::Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...
journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9067-4
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abstract::Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033484
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00222-z
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9180-4
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/10298420290007592
更新日期:2002-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00144-5
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9235-6
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abstract::Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9063-8
更新日期:2009-08-01 00:00:00
abstract::Myelin abnormalities, oligodendrocyte damage, and concomitant glia activation are common characteristics of demyelinating diseases of the central nervous system. Administration of the neurotoxicant cuprizone (CPZ) has been extensively used to establish a reproducible mouse model of demyelination. However, its effects ...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00154-3
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abstract::Previous studies using monotypic nerve cell cultures have shown that bilirubin-induced neurological dysfunction (BIND) involves apoptosis and necrosis-like cell death, following neuritic atrophy and astrocyte activation,and that glycoursodeoxycholic acid (GUDCA) has therapeutic efficacy against BIND. Cross-talk betwee...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9427-y
更新日期:2014-07-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9588-y
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-019-9999-2
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033264
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00163-7
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9520-5
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-013-9390-7
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00054-6
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-017-9740-y
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00258-1
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-012-9333-8
更新日期:2013-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-009-9018-0
更新日期:2009-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033183
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-020-00233-w
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033793
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