Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:Thioredoxin (Trx) and glyoxalase (Glo) systems have been suggested to be molecular targets of methylglyoxal (MGO). This highly reactive endogenous compound has been associated with the development of neurodegenerative pathologies and cell death. In the present study, the glutathione (GSH), Trx, and Glo systems were in...

journal_title：Neurotoxicity research

authors： Schmitz AE,de Souza LF,Dos Santos B,Maher P,Lopes FM,Londero GF,Klamt F,Dafre AL

更新日期：2017-10-01 00:00:00

abstract：:Neurotransmitters and neuromodulators are essential for normal nervous system development. Disturbances in the expression timetable or intensity of neurotransmitter signalling during critical periods of brain development can lead to permanent damage. Neuroactive drugs and environmental toxins interfere with neurotrans...

journal_title：Neurotoxicity research

authors： Kaindl AM,Ikonomidou C

更新日期：2007-04-01 00:00:00

abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

journal_title：Neurotoxicity research

authors： Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

更新日期：2019-04-01 00:00:00

abstract：:Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective...

journal_title：Neurotoxicity research

authors： Shi TY,Feng SF,Xing JH,Wu YM,Li XQ,Zhang N,Tian Z,Liu SB,Zhao MG

更新日期：2012-05-01 00:00:00

abstract：:Local anesthetics effectively block and relieve pain, but with a relatively short duration of action, limiting its analgesic effectiveness. Therefore, a long-acting local anesthetic would improve the management of pain, but no such agent is yet available for clinical use. The aim of this study is to evaluate the poten...

journal_title：Neurotoxicity research

authors： Rodriguez-Navarro AJ,Lagos M,Figueroa C,Garcia C,Recabal P,Silva P,Iglesias V,Lagos N

更新日期：2009-11-01 00:00:00

abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...

journal_title：Neurotoxicity research

authors： Fernandes CG,Pierozan P,Soares GM,Ferreira F,Zanatta Â,Amaral AU,Borges CG,Wajner M,Pessoa-Pureur R

更新日期：2015-10-01 00:00:00

abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...

journal_title：Neurotoxicity research

authors： Masserano JM,Baker I,Venable D,Gong L,Zullo SJ,Merril CR,Wyatt RJ

更新日期：2000-02-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...

journal_title：Neurotoxicity research

authors： Mester L,Szabo A,Atlasz T,Szabadfi K,Reglodi D,Kiss P,Racz B,Tamas A,Gallyas F Jr,Sumegi B,Hocsak E,Gabriel R,Kovacs K

更新日期：2009-07-01 00:00:00

abstract：:The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...

journal_title：Neurotoxicity research

authors： Goguadze N,Zhuravliova E,Morin D,Mikeladze D,Maurice T

更新日期：2019-01-01 00:00:00

abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...

journal_title：Neurotoxicity research

authors： Herpin G,Gargouri I,Gauchard GC,Nisse C,Khadhraoui M,Elleuch B,Zmirou-Navier D,Perrin PP

更新日期：2009-02-01 00:00:00

abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...

journal_title：Neurotoxicity research

authors： Beninger RJ

更新日期：2006-12-01 00:00:00

abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

journal_title：Neurotoxicity research

authors： Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

更新日期：2019-05-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:Sepsis-associated encephalopathy causes brain dysfunction that can result in cognitive impairments in sepsis survivor patients. In previous work, we showed that simvastatin attenuated oxidative stress in brain structures related to memory in septic rats. However, there is still a need to evaluate the long-term impact ...

journal_title：Neurotoxicity research

authors： Catalão CHR,Santos-Junior NN,da Costa LHA,Souza AO,Cárnio EC,Sebollela A,Alberici LC,Rocha MJA

更新日期：2020-12-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...

journal_title：Neurotoxicity research

authors： Cuevas C,Huenchuguala S,Muñoz P,Villa M,Paris I,Mannervik B,Segura-Aguilar J

更新日期：2015-04-01 00:00:00

abstract：:Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

journal_title：Neurotoxicity research

authors： Wojcieszak J,Kuczyńska K,Zawilska JB

更新日期：2021-01-11 00:00:00

abstract：:Melamine is an industrial chemical that can cause central nervous system disorders including excitotoxicity and cognitive impairment. Its illegal use in powdered baby formula was the focus of a milk scandal in China in 2008. One of our previous studies showed that melamine impaired glutamatergic transmission in rat hi...

journal_title：Neurotoxicity research

authors： Zhang H,Wang H,Xiao X,Zhang T

更新日期：2016-01-01 00:00:00

abstract：:Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...

journal_title：Neurotoxicity research

authors： Schamne MG,Mack JM,Moretti M,Matheus FC,Walz R,Lanfumey L,Prediger RD

更新日期：2018-11-01 00:00:00

abstract：:Botulinum neurotoxin (BoNT) has been used clinically since 1980, with an ever-increasing range of clinical applications. This has coincided with a period of massively expanded interest in the underlying biology of the neurotoxin. Tremendous advances have taken place in the scientific understanding of neurotoxin struct...

journal_title：Neurotoxicity research

authors： Foster KA,Bigalke H,Aoki KR

更新日期：2006-04-01 00:00:00

abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Zelek-Molik A,Antkiewicz-Michaluk L

更新日期：2018-04-01 00:00:00

abstract：:Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...

journal_title：Neurotoxicity research

authors： Wang HT,Huang FL,Hu ZL,Zhang WJ,Qiao XQ,Huang YQ,Dai RP,Li F,Li CQ

更新日期：2017-05-01 00:00:00

abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Dziubina A

更新日期：2012-08-01 00:00:00

abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...

journal_title：Neurotoxicity research

authors： Amini N,Vousooghi N,Hadjighassem M,Bakhtiyari M,Mousavi N,Safakheil H,Jafari L,Sarveazad A,Yari A,Ramezani S,Faghihi F,Joghataei MT

更新日期：2016-05-01 00:00:00

abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...

journal_title：Neurotoxicity research

authors： Honson NS,Jensen JR,Abraha A,Hall GF,Kuret J

更新日期：2009-04-01 00:00:00

abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...

journal_title：Neurotoxicity research

authors： Ślusarczyk J,Piotrowski M,Szczepanowicz K,Regulska M,Leśkiewicz M,Warszyński P,Budziszewska B,Lasoń W,Basta-Kaim A

更新日期：2016-11-01 00:00:00

abstract：:Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...

journal_title：Neurotoxicity research

authors： Zhang L,Qu Y,Tang B,Zhao F,Xiong T,Ferriero D,Mu D

更新日期：2012-11-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...

journal_title：Neurotoxicity research

authors： Boldyrev A,Bulygina E,Makhro A

更新日期：2004-01-01 00:00:00