Abstract:
:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when they were stimulated with apomorphine (0.5 mg/kg, s.c.), similar to rats injected unilaterally with 6-hydroxydopamine (6-OHDA). These rats also exhibited impairment of motor and cognitive behaviours. The results support the hypothesis that DT-diaphorase plays a protective role in the nigrostriatal dopaminergic systems.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar Jdoi
10.1007/BF03033183keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
629-33issue
8eissn
1029-8428issn
1476-3524journal_volume
5pub_type
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