Abstract：
:Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated the role of Zn in the regulation of these two critical events. A low Zn availability leads to decreased cell viability in human neuroblastoma IMR-32 cells and primary cultures of rat cortical neurons. This occurs in part as a consequence of decreased cell proliferation and increased apoptotic cell death. In IMR-32 cells, Zn deficiency led to the inhibition of cell proliferation through the arrest of the cell cycle at the G0/G1 phase. Zn deficiency induced apoptosis in both proliferating and quiescent neuronal cells via the intrinsic apoptotic pathway. Reductions in cellular Zn triggered a translocation of the pro-apoptotic protein Bad to the mitochondria, cytochrome c release, and caspase-3 activation. Apoptosis is the resultant of the inhibition of the prosurvival extracellular-signal-regulated kinase, the inhibition of nuclear factor-kappa B, and associated decreased expression of antiapoptotic proteins, and to a direct activation of caspase-3. A deficit of Zn during critical developmental periods can have persistent effects on brain function secondary to a deregulation of neuronal proliferation and apoptosis.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Adamo AM,Zago MP,Mackenzie GG,Aimo L,Keen CL,Keenan A,Oteiza PIdoi
10.1007/s12640-009-9067-4subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1-14issue
1eissn
1029-8428issn
1476-3524journal_volume
17pub_type
杂志文章abstract：:In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9497-5
更新日期：2015-01-01 00:00:00
abstract：:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9603-y
更新日期：2016-05-01 00:00:00
abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00163-7
更新日期：2020-03-01 00:00:00
abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033357
更新日期：2006-12-01 00:00:00
abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/1029842021000022089
更新日期：2002-08-01 00:00:00
abstract：:The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9838-2
更新日期：2019-01-01 00:00:00
abstract：:We have recently reported that global perinatal asphyxia (PA) induces a regionally sustained increase in oxidized glutathione (GSSG) levels and GSSG/GSH ratio, a decrease in tissue-reducing capacity, a decrease in catalase activity, and an increase in apoptotic caspase-3-dependent cell death in rat neonatal brain up t...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00064-4
更新日期：2019-10-01 00:00:00
abstract：:Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients (> or = 7 years-old) with autism spectrum disorders (ASDs) (Diagnos...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033334
更新日期：2006-08-01 00:00:00
abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033454
更新日期：2004-01-01 00:00:00
abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033305
更新日期：2006-01-01 00:00:00
abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00087-x
更新日期：2019-10-01 00:00:00
abstract：:The process of receptor supersensitivity (RSS) has a long history and is an epiphenomenon of neuronal denervation. Dopamine (DA) RSS (DARSS) similarly occurs after DA denervation, and this process is invoked in neuropsychiatric and neurodegenerative disorders. From studies largely over the past 25 years, much has been...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033804
更新日期：2008-10-01 00:00:00
abstract：:Neuronal cell death caused by pathophysiological over-activation of glutamate receptors and the subsequent CaII overloading, has been implicated in neurodegeneration after stroke, cerebral trauma and epileptic seizures. Recent findings suggest that certain progesterone metabolites (neurosteroids) such as allopregnanol...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033504
更新日期：2008-05-01 00:00:00
abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9967-2
更新日期：2019-04-01 00:00:00
abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290015908
更新日期：2002-03-01 00:00:00
abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9235-6
更新日期：2011-08-01 00:00:00
abstract：:Functional role(s) for the common neurotrophin receptor p75NTR in nerve growth factor (NGF) signaling have yet to be fully elucidated. Many studies have demonstrated that p75NTR can enhance nerve growth factor-induced survival mediated via the trkA receptor. In addition, newly identified pathways for p75NTR signaling ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033205
更新日期：2001-10-01 00:00:00
abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033778
更新日期：2005-01-01 00:00:00
abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033288
更新日期：2000-02-01 00:00:00
abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9611-y
更新日期：2016-08-01 00:00:00
abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033559
更新日期：2008-04-01 00:00:00
abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033814
更新日期：2008-10-01 00:00:00
abstract：:Alzheimer disease (AD) is a major cause of dementia. Several mechanisms have been postulated to explain its pathogenesis, beta-amyloid (A beta toxicity, cholinergic dysfunction, Tau hyper-phosphorylation, oxidative damage, synaptic dysfunction and inflammation secondary to senile plaques, among others. Glial cells are...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033906
更新日期：2007-12-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
abstract：:Genetic studies have sought to identify subtypes or endophenotypes of schizophrenia in an effort to improve the reliability of findings. A number of chromosomal regions or genes have now been shown to have had replicated linkage to schizophrenia susceptibility. Molecules involved in neurodevelopment or neurotransmitte...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033291
更新日期：2004-01-01 00:00:00
abstract：:Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to investigate the tremorgenic mechanism of paraoxon, an active metaboli...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-0007-7
更新日期：2019-04-01 00:00:00
abstract：:Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00321-x
更新日期：2021-01-05 00:00:00
abstract：:Depressive symptomatology is expressed across a wide spectrum of psychiatric disorders including major depression and schizophrenia. Further, depressive symptomatology is also observed in individuals undergoing withdrawal from chronic exposure to various drugs of abuse including cocaine, amphetamine and nicotine. The ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290023963
更新日期：2002-06-01 00:00:00
abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00294-x
更新日期：2020-10-06 00:00:00
abstract：:Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9652-2
更新日期：2016-11-01 00:00:00
