Abstract：
:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effects in adult rats that had been lesioned as neonates with the noradrenergic neurotoxin DSP-4. On the 1st and 3rd days after birth rat pups were treated with either saline or DSP-4 (50 mg/kg sc), then returned to their home cages with the dam. At 8 weeks when rats were tested, S(+)chlorpheniramine (10 mg/kg ip) was found to increase locomotor activity in intact and DSP-4 lesioned rats, while cimetidine (5 mg/kg, ip) and thioperimide (5 mg/kg, ip) increased activity several-fold solely in the DSP-4 group. Exploratory activity, nociceptive activity, and irritability were little altered by the histamine antagonists, although oral activity was increased by thioperimide in intact and lesioned rats, and by cimetidine or S(+)chlorpheniramine in DSP-4 rats. High performance liquid chromatography with electrochemical detection was used to determine that DSP-4 produced a 90% reduction in frontal cortex, hippocampus and hypothalamus, with a 90% elevation of NE in cerebellum--reflecting reactive sprouting of noradrenergic fibers consequent to lesion of noradrenergic tracts projecting to proximal brain regions. These findings indicate that perinatal noradrenergic fiber lesioning in rat brain is associated with an altered behavioral spectrum by histamine H1, H2 and H3 receptor antagonists, thereby implicating histaminergic systems as modulators of noradrenergic systems in brain.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus Rdoi
10.1007/BF03033559subject
Has Abstractpub_date
2008-04-01 00:00:00pages
79-83issue
2eissn
1029-8428issn
1476-3524journal_volume
13pub_type
杂志文章abstract：:The senile plaques (SPs) and neurofibrillary tangles (NFTs) are the two major pathological hallmarks of AD, which are composed of β-amyloid protein and Tau protein. So the β-amyloid protein (Aβ) and Tau oligomers (oTau) are the majority in the pathology of AD. Recently, the spreading of Aβ and oTau in the brain of AD ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-017-9765-2
更新日期：2017-11-01 00:00:00
abstract：:Multiple lines of evidence demonstrate that reactive oxygen species (ROS) are involved in regulation of normal cell metabolism as second messengers. Under extreme conditions, these molecules induce oxidative stress, which may stimulate (or accompany) a number of neurodegenerative processes. In the glutamatergic system...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/BF03033454
更新日期：2004-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 已发布勘误
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更新日期：2019-05-01 00:00:00
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journal_title：Neurotoxicity research
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doi：10.1007/s12640-016-9652-2
更新日期：2016-11-01 00:00:00
abstract：:During neonatal life, offspring can be affected by toxic agents either by transfer via mother's milk or by direct exposure. In many mammalian species the perinatal period is characterized by a rapid development of the brain - "the brain growth spurt" (BGS). This period in the development of the mammalian brain is asso...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033229
更新日期：2001-01-01 00:00:00
abstract：:GSK3beta is prominent for its role in apoptosis signaling and has been shown to be involved in Parkinson's disease (PD) pathogenesis. The overall effects of GSK3beta activity on cell fate are well-established, but the effects of mitochondrial GSK3beta activity on mitochondrial function and cell fate are unknown. Here ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033861
更新日期：2008-12-01 00:00:00
abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9372-1
更新日期：2013-07-01 00:00:00
abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290015908
更新日期：2002-03-01 00:00:00
abstract：:Mobile phone communications are conveyed by radiofrequency (RF) electromagnetic fields, including pulse-modulated global system for mobile communications (GSM)-1800 MHz, whose effects on the CNS affected by pathological states remain to be specified. Here, we investigated whether a 2-h head-only exposure to GSM-1800 M...
journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033484
更新日期：2007-01-01 00:00:00
abstract：:There has been a growing recognition of the role of neuroinflammation caused by microglia-exaggerated release of inflammatory mediators in the pathogenesis of Parkinson's disease (PD). Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous 38 amino acid containing neuropeptide that has been shown ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9468-x
更新日期：2014-10-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting from the progressive loss of motor neurons in the spinal cord and brain. To date, clinically effective neuroprotective agents have not been available. The current study demonstrates for the first time that huperzine A, a potential neuroprotec...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033367
更新日期：2008-01-01 00:00:00
abstract：:The classical motor symptoms of Parkinson’s disease (PD) are preceded by non-motor symptoms in preclinical stages, including cognition impairment. The current drug treatment for PD is palliative and does not meet the clinical challenges of the disease, such as levodopa-induced dyskinesia, non-motor symptoms, and neuro...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9566-4
更新日期：2016-01-01 00:00:00
abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9836-4
更新日期：2018-05-01 00:00:00
abstract：:A widely held view suggests that homocysteine (Hcy) can contribute to neurodegeneration through promotion of oxidative stress. There is evidence that homocysteine is toxic to cerebellar Purkinje neurons in vitro; however, in vivo action of Hcy on Purkinje cell has not been investigated so far. Thus, this study was des...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9979-y
更新日期：2019-04-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9827-5
更新日期：2018-05-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9686-5
更新日期：2017-04-01 00:00:00
abstract：:The expanding arsenal of transgenic mice has created a powerful tool for investigating the biological mechanisms involved in ototoxicity. However, cisplatin ototoxicity is difficult to investigate in mice because of their small size and vulnerability to death by nephrotoxicity. To overcome this problem, we developed a...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9244-0
更新日期：2011-11-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9294-3
更新日期：2012-05-01 00:00:00
abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9049-6
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033188
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00030-0
更新日期：2019-07-01 00:00:00
abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033901
更新日期：2007-07-01 00:00:00
abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9316-9
更新日期：2012-08-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9250-2
更新日期：2011-11-01 00:00:00
abstract：:Our previous investigation showed that melamine in offspring hippocampus appeared to not be the critical factor for cognitive defects. The present study was to investigate whether the cognitive impairments induced by prenatal and postnatal melamine exposure and persisted into adulthood, and to evaluate the differences...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9578-0
更新日期：2016-02-01 00:00:00
abstract：:In multicellular organisms, all the cells are genetically identical but turn genes on or off at the right time to promote differentiation into specific cell types. The regulation of higher-order chromatin structure is essential for genome-wide reprogramming and for tissue-specific patterns of gene expression. The comp...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-014-9497-5
更新日期：2015-01-01 00:00:00
abstract：:Methylglyoxal (MG) is formed during normal metabolism by processes like glycolysis, lipid peroxidation, and threonine catabolism, and its accumulation is associated with various degenerative diseases, such as diabetes and arterial atherogenesis. Furthermore, MG has also been reported to have toxic effects on hippocamp...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9588-y
更新日期：2016-04-01 00:00:00
abstract：:Reoccurring seasonal cyanobacterial harmful algal blooms (CHABs) persist in many waters, and recent work has shown links between CHAB and elevated risk of amyotrophic lateral sclerosis (ALS). Quantifying the exposure levels of CHAB as a potential risk factor for ALS is complicated by human mobility, potential pathways...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9740-y
更新日期：2018-01-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
