Evaluation of levodopa and carbidopa antioxidant activity in normal human lymphocytes in vitro: implication for oxidative stress in Parkinson's disease.

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...

journal_title：Neurotoxicity research

authors： Milosevic J,Adler I,Manaenko A,Schwarz SC,Walkinshaw G,Arend M,Flippin LA,Storch A,Schwarz J

更新日期：2009-05-01 00:00:00

abstract：:We present for discussion a possible molecular mechanism explaining the formation of reactive oxygen species involved in the neurodegenerative process of dopaminergic system in Parkinson's disease. This new hypothesis involves one-electron reduction of aminochrome to o-semiquinone radical, which seems to be the reacti...

journal_title：Neurotoxicity research

authors： Segura-Aguilar J,Metodiewa D,Baez S

更新日期：2001-04-01 00:00:00

abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...

journal_title：Neurotoxicity research

authors： Masserano JM,Baker I,Venable D,Gong L,Zullo SJ,Merril CR,Wyatt RJ

更新日期：2000-02-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...

journal_title：Neurotoxicity research

authors： Amini N,Vousooghi N,Hadjighassem M,Bakhtiyari M,Mousavi N,Safakheil H,Jafari L,Sarveazad A,Yari A,Ramezani S,Faghihi F,Joghataei MT

更新日期：2016-05-01 00:00:00

abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...

journal_title：Neurotoxicity research

authors： Honson NS,Jensen JR,Abraha A,Hall GF,Kuret J

更新日期：2009-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that is hallmarked by pathological changes associated with the death of dopaminergic neurons, particularly in the extrapyramidal system (substantia nigra pars compacta, striatum) of the brain. Although the causes of slow neuronal death in PD are unknown, both ge...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Zelek-Molik A,Nalepa I,Antkiewicz-Michaluk L

更新日期：2016-04-01 00:00:00

abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...

journal_title：Neurotoxicity research

authors： Fernandes CG,Pierozan P,Soares GM,Ferreira F,Zanatta Â,Amaral AU,Borges CG,Wajner M,Pessoa-Pureur R

更新日期：2015-10-01 00:00:00

abstract：:One of the authors has incorrect family name spelling in the original article. Michael Ashner should read as Michael Aschner. ...

journal_title：Neurotoxicity research

authors： Colonnello A,Aguilera-Portillo G,Rubio-López LC,Robles-Bañuelos B,Rangel-López E,Cortez-Núñez S,Evaristo-Priego Y,Silva-Palacios A,Galván-Arzate S,García-Contreras R,Túnez I,Chen P,Aschner M,Santamaría A

更新日期：2020-03-01 00:00:00

abstract：:U373MG cells are able to take up aminochrome that induces glutathione transferase M2-2 (GSTM2) expression in a concentration-dependent manner where 100 µM aminochrome increases GSTM2 expression by 2.1-fold (P < 0.001) at 3 h. The uptake of (3)H-aminochrome into U373MG cells was significantly reduced in the presence of...

journal_title：Neurotoxicity research

authors： Cuevas C,Huenchuguala S,Muñoz P,Villa M,Paris I,Mannervik B,Segura-Aguilar J

更新日期：2015-04-01 00:00:00

abstract：:The hippocampus plays an important role in memory, mood, and spatial navigation. In the dentate gyrus of the adult hippocampus, in the subgranular zone (SGZ), new cells are generated, which differentiate and mature into new neurons. Cisplatin, a highly effective antineoplastic drug with nephrotoxic and ototoxic side e...

journal_title：Neurotoxicity research

authors： Hinduja S,Kraus KS,Manohar S,Salvi RJ

更新日期：2015-04-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Deficit schizophrenia is characterized by leaky intestinal tight and adherens junctions and bacterial translocation. Here we examine whether (deficit) schizophrenia is accompanied by leaky paracellular, transcellular, and vascular barriers in the gut and blood-brain barriers. We measured IgA responses to occludin, cla...

journal_title：Neurotoxicity research

authors： Maes M,Sirivichayakul S,Kanchanatawan B,Vodjani A

更新日期：2019-08-01 00:00:00

abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...

journal_title：Neurotoxicity research

authors： Li F,Wang XS,Dai RP,Zhang JY,Zhou XF,Hao W,Li CQ

更新日期：2011-11-01 00:00:00

abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...

journal_title：Neurotoxicity research

authors： Lipska BK,Weinberger DR

更新日期：2002-08-01 00:00:00

abstract：:Early-life stress is a potent risk factor for development of psychiatric conditions such as depression. The underlying mechanisms remain poorly understood. Here, we used the early-life social isolation (ESI) model of early-life stress in rats to characterize development of depressive-like behavior, the role of microgl...

journal_title：Neurotoxicity research

authors： Wang HT,Huang FL,Hu ZL,Zhang WJ,Qiao XQ,Huang YQ,Dai RP,Li F,Li CQ

更新日期：2017-05-01 00:00:00

abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...

journal_title：Neurotoxicity research

authors： Fernandez LL,de Lima MN,Scalco F,Vedana G,Miwa C,Hilbig A,Vianna M,Schröder N

更新日期：2011-08-01 00:00:00

abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...

journal_title：Neurotoxicity research

authors： Endesfelder S,Weichelt U,Schiller C,Winter K,von Haefen C,Bührer C

更新日期：2018-08-01 00:00:00

abstract：:Mercury is a toxic metal shown to have harmful effects on human health. Several studies have reported high blood mercury concentrations as a risk factor for autism spectrum disorders (ASDs), while other studies have reported no such association. The goal of this study was to investigate the association between blood m...

journal_title：Neurotoxicity research

authors： Rahbar MH,Samms-Vaughan M,Loveland KA,Ardjomand-Hessabi M,Chen Z,Bressler J,Shakespeare-Pellington S,Grove ML,Bloom K,Pearson DA,Lalor GC,Boerwinkle E

更新日期：2013-01-01 00:00:00

abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Michaluk J,Kajta M,Antkiewicz-Michaluk L

更新日期：2014-10-01 00:00:00

abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...

journal_title：Neurotoxicity research

authors： Alnoud MAH,Chen W,Liu N,Zhu W,Qiao J,Chang S,Wu Y,Wang S,Yang Y,Sun Q,Kang J

更新日期：2020-10-06 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

journal_title：Neurotoxicity research

authors： Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

更新日期：2020-08-01 00:00:00

abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

journal_title：Neurotoxicity research

authors： Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

更新日期：2019-07-01 00:00:00

abstract：:The sigma1 receptor (σ1R) is a chaperone protein residing at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), where it modulates Ca2+ exchange between the ER and mitochondria by interacting with inositol-1,4,5 trisphosphate receptors (IP3Rs). The σ1R is highly expressed in the central nervous syste...

journal_title：Neurotoxicity research

authors： Goguadze N,Zhuravliova E,Morin D,Mikeladze D,Maurice T

更新日期：2019-01-01 00:00:00

abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...

journal_title：Neurotoxicity research

authors： Ghasemi F,Bagheri H,Barreto GE,Read MI,Sahebkar A

更新日期：2019-07-01 00:00:00

abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...

journal_title：Neurotoxicity research

authors： Rai SN,Singh BK,Rathore AS,Zahra W,Keswani C,Birla H,Singh SS,Dilnashin H,Singh SP

更新日期：2019-10-01 00:00:00

abstract：:Non-motor symptoms are increasingly identified to present clinical and diagnostic importance for Parkinson's disease (PD). The multifactorial origin of pain in PD makes this symptom of great complexity. The dopamine precursor, L-DOPA (L-3,4-dihydroxyphenylalanine), the classic therapy for PD, seems to be effective in ...

journal_title：Neurotoxicity research

authors： Nascimento GC,Bariotto-Dos-Santos K,Leite-Panissi CRA,Del-Bel EA,Bortolanza M

更新日期：2018-11-01 00:00:00

abstract：:Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...

journal_title：Neurotoxicity research

authors： Zhang L,Qu Y,Tang B,Zhao F,Xiong T,Ferriero D,Mu D

更新日期：2012-11-01 00:00:00