Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage.

abstract：:In humans, Down syndrome (DS) is caused by the presence of an extra copy of autosome 21. The most striking finding in DS patients is intellectual disability and the onset of Alzheimer's disease (AD)-like neuropathology in adulthood. Gene overdose is most likely to underlie both developmental impairments, as well as al...

journal_title：Neurotoxicity research

authors： Pérez-Núñez R,Barraza N,Gonzalez-Jamett A,Cárdenas AM,Barnier JV,Caviedes P

更新日期：2016-07-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...

journal_title：Neurotoxicity research

authors： Rashedinia M,Saberzadeh J,Khosravi Bakhtiari T,Hozhabri S,Arabsolghar R

更新日期：2019-04-01 00:00:00

abstract：:Ketamine is widely used as an anesthetic in pediatric clinical practice. However, numerous studies have reported that exposure to ketamine during the developmental period induces neurotoxicity. Here we investigate the neuroprotective effects of baicalin, a natural flavonoid compound, against ketamine-induced apoptotic...

journal_title：Neurotoxicity research

authors： Zuo D,Lin L,Liu Y,Wang C,Xu J,Sun F,Li L,Li Z,Wu Y

更新日期：2016-08-01 00:00:00

abstract：:Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...

journal_title：Neurotoxicity research

authors： Niu Q,Yang Y,Zhang Q,Niu P,He S,Di Gioacchino M,Conti P,Boscolo P

更新日期：2007-10-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...

journal_title：Neurotoxicity research

authors： Willing AE,Saporta S,Lixian J,Milliken M,Poulos S,Bowersox SS,Sanberg PR

更新日期：2002-03-01 00:00:00

abstract：:Intracerebral or intraperitoneal injections of brain extracts from the Alzheimer's disease patients result in the acceleration of cerebral β-amyloidosis in transgenic mice. Earlier, we have found that intravenous injections of synthetic full-length amyloid-β (Aβ) comprising the isomerized Asp7 trigger cerebral β-amylo...

journal_title：Neurotoxicity research

authors： Kulikova AA,Cheglakov IB,Kukharsky MS,Ovchinnikov RK,Kozin SA,Makarov AA

更新日期：2016-05-01 00:00:00

abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...

journal_title：Neurotoxicity research

authors： Shcherbitskaia AD,Vasilev DS,Milyutina YP,Tumanova NL,Zalozniaia IV,Kerkeshko GO,Arutjunyan AV

更新日期：2020-08-01 00:00:00

abstract：:The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. The main compounds used for Alzheimer's treatment are acetylcholinesterase inhibitors. Quercetin c...

journal_title：Neurotoxicity research

authors： da Silva WMB,de Oliveira Pinheiro S,Alves DR,de Menezes JESA,Magalhães FEA,Silva FCO,Silva J,Marinho ES,de Morais SM

更新日期：2020-04-01 00:00:00

abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...

journal_title：Neurotoxicity research

authors： Dircio-Bautista M,Colín-González AL,Aguilera G,Maya-López M,Villeda-Hernández J,Galván-Arzate S,García E,Túnez I,Santamaría A

更新日期：2018-05-01 00:00:00

abstract：:Depression is a highly prevalent and debilitating non-motor symptom observed during the early stages of Parkinson's disease (PD). Although PD prevalence is higher in men, the depressive symptoms in PD are more common in women. Therefore, the aim of this study was to investigate the development of anhedonic- and depres...

journal_title：Neurotoxicity research

authors： Schamne MG,Mack JM,Moretti M,Matheus FC,Walz R,Lanfumey L,Prediger RD

更新日期：2018-11-01 00:00:00

abstract：:In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid...

journal_title：Neurotoxicity research

authors： Manzanares J,Urigüen L,Rubio G,Palomo T

更新日期：2004-01-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of oxygen and iron, hypoxia-inducible factor 1 alpha (HIF-1alpha) is rapidly degraded via the prolyl hydroxylase (PHD)/VHL pathway. In addition to hypoxia, various no...

journal_title：Neurotoxicity research

authors： Milosevic J,Adler I,Manaenko A,Schwarz SC,Walkinshaw G,Arend M,Flippin LA,Storch A,Schwarz J

更新日期：2009-05-01 00:00:00

abstract：:Parkinson's disease is a slowly progressing disease, due to a lesion of dopaminergic neurons in the substantia nigra and a dramatic loss of dopamine in the striatum. It is now accepted that several environmental agents including the herbicide paraquat (PQ) may contribute to its pathogenesis. However, till now nothing ...

journal_title：Neurotoxicity research

authors： Songin M,Strosznajder JB,Fitał M,Kuter K,Kolasiewicz W,Nowak P,Ossowska K

更新日期：2011-01-01 00:00:00

abstract：:Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin protea...

journal_title：Neurotoxicity research

authors： Dikshit P,Goswami A,Mishra A,Chatterjee M,Jana NR

更新日期：2006-01-01 00:00:00

abstract：:Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers. Cathinones produce psychostimulant and empathogenic effects by enhancing dopaminergic, noradrenergic, and serotoninergic neurotransmission in the brain, and those which potently...

journal_title：Neurotoxicity research

authors： Wojcieszak J,Kuczyńska K,Zawilska JB

更新日期：2021-01-11 00:00:00

abstract：:Cellular oxidative stress and energy failure were shown to be involved in Glutamate (L-Glu) neurotoxicity, whereas, acetyl-L-carnitine (ALCAR) and ±DL-α-lipoic acid (LA) are known to be key players in the mitochondrial energy production. To evaluate the effects of the above antioxidants, adult rats were pretreated wit...

journal_title：Neurotoxicity research

authors： Nagesh Babu G,Kumar A,Singh RL

更新日期：2011-02-01 00:00:00

abstract：:Patients scheduled for cochlear implantation often retain residual hearing in the low frequencies. Unfortunately, some patients lose their residual hearing following implantation and the reasons for this are not well understood. Evidence suggests that electrotoxicity could be one of the factors responsible for this la...

journal_title：Neurotoxicity research

authors： Peter MN,Warnecke A,Reich U,Olze H,Szczepek AJ,Lenarz T,Paasche G

更新日期：2019-07-01 00:00:00

abstract：:The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induct...

journal_title：Neurotoxicity research

authors： Rauš S,Selaković V,Manojlović-Stojanoski M,Radenović L,Prolić Z,Janać B

更新日期：2013-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...

journal_title：Neurotoxicity research

authors： Lei H,Zhang Y,Huang L,Xu S,Li J,Yang L,Wang L,Xing C,Wang X,Peng Y

更新日期：2018-10-01 00:00:00

abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...

journal_title：Neurotoxicity research

authors： Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli M

更新日期：2010-05-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the...

journal_title：Neurotoxicity research

authors： Yu ZY,Li WW,Yang HM,Mañucat-Tan NB,Wang J,Wang YR,Sun BL,Hu ZC,Zhang LL,Tan L,Deng J,Liu YH

更新日期：2020-04-01 00:00:00

abstract：:Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...

journal_title：Neurotoxicity research

authors： Wang H,Yue Y,Zhao H,Wu H,Jiang K,Li S,Zhao M,Lin F

更新日期：2021-01-05 00:00:00

abstract：:Tissue accumulation of L-2-hydroxyglutaric acid (L-2-HG) is the biochemical hallmark of L-2-hydroxyglutaric aciduria (L-2-HGA), a rare neurometabolic inherited disease characterized by neurological symptoms and brain white matter abnormalities whose pathogenesis is not yet well established. L-2-HG was intracerebrally ...

journal_title：Neurotoxicity research

authors： Ribeiro RT,Zanatta Â,Amaral AU,Leipnitz G,de Oliveira FH,Seminotti B,Wajner M

更新日期：2018-04-01 00:00:00

abstract：:The study shows effects of the nonselective adenosine A1/A2A receptor antagonist caffeine and the selective A2A receptor antagonist KW6002 on LPS-induced changes in the extracellular levels of dopamine (DA), glutamate, adenosine, hydroxyl radical, and A2A receptor density in the rat striatum. Intrastriatal LPS (10 μg)...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Wardas J,Noworyta-Sokołowska K,Kamińska K,Górska A

更新日期：2013-07-01 00:00:00

abstract：:Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH...

journal_title：Neurotoxicity research

authors： Tang WZ,Wang XB,Li HT,Dong M,Ji X

更新日期：2017-10-01 00:00:00

abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...

journal_title：Neurotoxicity research

authors： Tizabi Y,Al-Namaeh M,Manaye KF,Taylor RE

更新日期：2003-01-01 00:00:00

abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....

journal_title：Neurotoxicity research

authors： de Oliveira MR,Duarte AR,Chenet AL,de Almeida FJS,Andrade CMB

更新日期：2019-10-01 00:00:00