The developing cholinergic system as target for environmental toxicants, nicotine and polychlorinated biphenyls (PCBs): implications for neurotoxicological processes in mice.

abstract：:Levetiracetam (LVT) is a relatively novel antiepileptic drug (AED) known to act through binding with the synaptic vesicular 2A (SV2A) protein, thus modulating the presynaptic neurotransmitter release. The tryptophan metabolite quinolinic acid (QUIN) acts as an excitotoxin when its brain concentrations reach toxic leve...

journal_title：Neurotoxicity research

authors： Dircio-Bautista M,Colín-González AL,Aguilera G,Maya-López M,Villeda-Hernández J,Galván-Arzate S,García E,Túnez I,Santamaría A

更新日期：2018-05-01 00:00:00

abstract：:The isolated sciatic nerve of the frog was used to assess the effects of the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) on the peripheral nervous system. For each experiment, both sciatic nerves were used. The evoked compound action potentials of the nerves were monitored for over 48 h as an indication of their ...

journal_title：Neurotoxicity research

authors： Kouri G,Theophilidis G

更新日期：2002-02-01 00:00:00

abstract：:This study was aimed to investigate neuropathological changes in adult and aged rats subjected to supplementary iron administration in a critical postnatal period to study the contribution of environmental risk factors to the pathogenesis of neurodegenerative disorders. Ten rats received a single daily oral administra...

journal_title：Neurotoxicity research

authors： Fernandez LL,de Lima MN,Scalco F,Vedana G,Miwa C,Hilbig A,Vianna M,Schröder N

更新日期：2011-08-01 00:00:00

abstract：:High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic...

journal_title：Neurotoxicity research

authors： Herpin G,Gargouri I,Gauchard GC,Nisse C,Khadhraoui M,Elleuch B,Zmirou-Navier D,Perrin PP

更新日期：2009-02-01 00:00:00

abstract：:Dopamine can be autoxidized to superoxides and quinones. Superoxides can form hydroxyl radicals that are highly reactive with lipids, proteins and DNA leading to neuronal damage and cell death. We used a clonal catecholaminergic cell line (CATH.a) derived from the central nervous system to evaluate the effects of dopa...

journal_title：Neurotoxicity research

authors： Masserano JM,Baker I,Venable D,Gong L,Zullo SJ,Merril CR,Wyatt RJ

更新日期：2000-02-01 00:00:00

abstract：:The rate of mitosis of cancer cells is significantly higher than normal primary cells with increased metabolic needs, which in turn enhances the generation of reactive oxygen species (ROS) production. Higher ROS production is known to increase cancer cell dependence on ROS scavenging systems to counteract the increase...

journal_title：Neurotoxicity research

authors： Ertilav K,Nazıroğlu M,Ataizi ZS,Braidy N

更新日期：2019-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive degeneration of brain and spinal cord motor neurons. Ubiquitin-proteasome system (UPS) dysfunction and oxidative stress have been implicated in ALS pathogenesis. However, it is unknown whether the defects in thes...

journal_title：Neurotoxicity research

authors： Yang S,Zhang KY,Kariawasam R,Bax M,Fifita JA,Ooi L,Yerbury JJ,Nicholson GA,Blair IP

更新日期：2015-08-01 00:00:00

abstract：:Ethanol is a neuroteratogen and neurodegeneration is the most devastating consequence of developmental exposure to ethanol. A sublethal preconditioning has been proposed as a neuroprotective strategy against several central nervous system neurodegenerative diseases. We have recently demonstrated that autophagy is a pr...

journal_title：Neurotoxicity research

authors： Wang H,Bower KA,Frank JA,Xu M,Luo J

更新日期：2013-11-01 00:00:00

abstract：:Accumulating data support axonal degeneration as the major determinant of irreversible neurological disability in patients with multiple sclerosis (MS). The extent of axonal injury correlates with the degree of inflammation in active MS lesions and occurs at early stages of disease, indicating that inflammatory demyel...

journal_title：Neurotoxicity research

authors： Bjartmar C,Trapp BD

更新日期：2003-01-01 00:00:00

abstract：:Rats lesioned shortly after birth with 6-hydroxydopamine (6-OHDA; 134 μg icv) represent a near-ideal model of severe Parkinson's disease because of the near-total destruction of nigrostriatal dopaminergic fibers. There are scarce data that in Parkinson's disease, activity of the central histaminergic system is increas...

journal_title：Neurotoxicity research

authors： Brus R,Jochem J,Nowak P,Adwent M,Boroń D,Brus H,Kostrzewa RM

更新日期：2012-02-01 00:00:00

abstract：:The main pathochemical hallmark of Parkinson's disease (PD) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (L-dopa) is a treatment that partially restores the dopaminergic transmission. In vitro assays have demonstrated both toxic and protective effects of L-dopa on dopam...

journal_title：Neurotoxicity research

authors： Colamartino M,Santoro M,Duranti G,Sabatini S,Ceci R,Testa A,Padua L,Cozzi R

更新日期：2015-02-01 00:00:00

abstract：:In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for ca...

journal_title：Neurotoxicity research

authors： Endesfelder S,Weichelt U,Schiller C,Winter K,von Haefen C,Bührer C

更新日期：2018-08-01 00:00:00

abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...

journal_title：Neurotoxicity research

authors： Gołembiowska K,Dziubina A

更新日期：2012-08-01 00:00:00

abstract：:Several reports suggest that 3,4-methylenedioxymethamphetamine (MDMA) induces neurotoxic effects and gliosis. Since recreational use of MDMA is often associated with caffeinated beverages, we investigated whether caffeine interferes with MDMA-induced astroglia and microglia activation, thus facilitating its neurotoxic...

journal_title：Neurotoxicity research

authors： Khairnar A,Plumitallo A,Frau L,Schintu N,Morelli M

更新日期：2010-05-01 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), the causative agents of botulism, are potent inhibitors of neurotransmitter release from motor neurons. There are currently no drugs to treat BoNT intoxication after the onset of the disease symptoms. In this study, we explored how modulation of key host pathways affects the process of B...

journal_title：Neurotoxicity research

authors： Kiris E,Burnett JC,Nuss JE,Wanner LM,Peyser BD,Du HT,Gomba GY,Kota KP,Panchal RG,Gussio R,Kane CD,Tessarollo L,Bavari S

更新日期：2015-05-01 00:00:00

abstract：:Hyperfunction of brain dopamine (DA) systems is associated with psychosis in schizophrenia and the medications used to treat schizophrenia are DA receptor blockers. DA also plays a critical role in incentive learning produced by rewarding stimuli. Using DA as the link, these results suggest that psychosis in schizophr...

journal_title：Neurotoxicity research

authors： Beninger RJ

更新日期：2006-12-01 00:00:00

abstract：:Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are kno...

journal_title：Neurotoxicity research

authors： Skórkowska A,Maciejska A,Pomierny B,Krzyżanowska W,Starek-Świechowicz B,Bystrowska B,Broniowska Ż,Kazek G,Budziszewska B

更新日期：2020-03-01 00:00:00

abstract：:To determine whether noradrenergic nerves might have a modulatory role on the sensitivity or reactivity of histaminergic receptor systems in brain, behavioral effects of the respective histamine H1, H2 and H3 antagonists S(+)chlorpheniramine, cimetidine and thioperimide in control adult rats were compared to the effec...

journal_title：Neurotoxicity research

authors： Nowak P,Jochem J,Zwirska-Korczala K,Josko J,Noras L,Kostrzewa RM,Brus R

更新日期：2008-04-01 00:00:00

abstract：:The original version of this article contained mistakes, and the authors would like to correct them. Some parts of the image in Figure 5 were missing. The correct Figure 5 is shown at the next page. ...

journal_title：Neurotoxicity research

authors： Li H,Song S,Wang Y,Huang C,Zhang F,Liu J,Hong JS

更新日期：2019-05-01 00:00:00

abstract：:Aging plays a significant role in the progression of vascular diseases and vascular dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory signals may cause vascular permeability and endothelial leakage. Pro-inflammatory molecules have a significant effect on smooth muscle cells (SM...

journal_title：Neurotoxicity research

authors： Uddin MS,Kabir MT,Jakaria M,Mamun AA,Niaz K,Amran MS,Barreto GE,Ashraf GM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin neutralization is classically attributed to the Fab and F(ab')2 fragments of antibodies. Herein, we generated Fab and F(ab')2 fragments of thre...

journal_title：Neurotoxicity research

authors： Ghotloo S,Amiri MM,Khoshnoodi J,Abbasi E,Jeddi-Tehrani M,Golsaz-Shirazi F,Shokri F

更新日期：2020-03-01 00:00:00

abstract：:There is a long-standing debate about whether rats have what could be considered a prefrontal cortex (PFC) and, if they do, what its primate homologue is. Anatomical evidence supports the view that the rat medial PFC is related to both the primate anterior cingulate cortex (ACC) and the dorsolateral PFC. Functionally ...

journal_title：Neurotoxicity research

authors： Seamans JK,Lapish CC,Durstewitz D

更新日期：2008-10-01 00:00:00

abstract：:Reinforcing effects of addictive drugs can be evaluated with the conditioned place preference (CPP) test which involves both the action of drugs and environmental cues. However, the encoded neural circuits and underlying signaling mechanism are not fully understood. In this study, we have used morphine-CPP model in th...

journal_title：Neurotoxicity research

authors： Li F,Wang XS,Dai RP,Zhang JY,Zhou XF,Hao W,Li CQ

更新日期：2011-11-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare and fatal α-synucleinopathy characterized by a distinctive oligodendrogliopathy with glial cytoplasmic inclusions and associated neuronal multisystem degeneration. The majority of patients presents with a rapidly progressive parkinsonian disorder and atypical features such as ea...

journal_title：Neurotoxicity research

authors： Stefanova N,Georgievska B,Eriksson H,Poewe W,Wenning GK

更新日期：2012-05-01 00:00:00

abstract：:The present study shows that intranigral injection of dicoumarol, a DT-diaphorase inhibitor, potentiates the neurotoxic effect of salsolinol (salsolinol 1.25 nmoles plus dicoumarol 2 nmoles; in 2 microl). Rats treated with dicoumarol plus salsolinol presented a characteristic contralateral rotational behaviour when th...

journal_title：Neurotoxicity research

authors： Díaz-Véliz G,Mora S,Lungenstrass H,Segura-Aguilar J

更新日期：2004-01-01 00:00:00

abstract：:The deaths of neurons, astrocytes and endothelial cells have been described in patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect neurons; instead, neurotoxic substances shed by infected glia and macrophages can induce a form of programmed cell death called apoptosis in neurons. These neu...

journal_title：Neurotoxicity research

authors： Li W,Galey D,Mattson MP,Nath A

更新日期：2005-10-01 00:00:00

abstract：:Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of newborn rats to a variety of anesthetics has been shown to induce apoptotic neurodegeneration in the developing brain. Newborn Wistar rats were treated with repeated intraperitoneal injections of propofol or sevoflurane inhalation an...

journal_title：Neurotoxicity research

authors： Bercker S,Bert B,Bittigau P,Felderhoff-Müser U,Bührer C,Ikonomidou C,Weise M,Kaisers UX,Kerner T

更新日期：2009-08-01 00:00:00

abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...

journal_title：Neurotoxicity research

authors： Wąsik A,Romańska I,Zelek-Molik A,Antkiewicz-Michaluk L

更新日期：2018-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (...

journal_title：Neurotoxicity research

authors： Lei H,Zhang Y,Huang L,Xu S,Li J,Yang L,Wang L,Xing C,Wang X,Peng Y

更新日期：2018-10-01 00:00:00

abstract：:Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer's disease and certain forms of frontotemporal lobar degeneration. These lesions are composed largely of tau protein, which aggregates to form intracellular fibrils in affected neurons. Previously it was shown that...

journal_title：Neurotoxicity research

authors： Honson NS,Jensen JR,Abraha A,Hall GF,Kuret J

更新日期：2009-04-01 00:00:00