Abstract：
:This commentary serves as an introduction to the magnetic resonance imaging (MRI) technique called diffusion kurtosis imaging (DKI) employed in the study by Arab et al. in the present issue of Neurotoxicology Research. In their study, DKI is employed for longitudinal investigation of a methamphetamine intoxication model of Parkinson's disease. The study employs an impressive number of animals and combines DKI with behavioral analysis at multiple time points. The commentary discusses some aspects of the study design especially the strength of combining behavioral analysis with MRI in an effort to provide as thorough a characterization and validity assessment of the animal model and cohort as possible. The potential clinical value of combining multiple MRI techniques (multimodal MRI) in PD is discussed as well as the benefit of multimodal MRI combined with behavioral analysis and subsequent histological analysis for in-depth characterization of animal models.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Hansen Bdoi
10.1007/s12640-019-00100-3subject
Has Abstractpub_date
2020-01-01 00:00:00pages
41-47issue
1eissn
1029-8428issn
1476-3524pii
10.1007/s12640-019-00100-3journal_volume
37pub_type
评论,杂志文章abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease (PD). Our previous studies have observed that Rg1, a major pharmacologically active ingredient from Ginseng, could protect dopaminergic neurons by reducing nigral iron levels through regulating the expression of iron transporters...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9362-3
更新日期：2013-07-01 00:00:00
abstract：:Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect of PTE on the activity of antiepileptic drugs in the acute seizure tests in mice, i.e., the intravenous pentetrazole (iv PTZ) seizure threshold, m...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00021-1
更新日期：2019-11-01 00:00:00
abstract：:Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a metabolite of dopamine, may act as an endogenous neurotoxin and contribute to the etiology of Parkinson's disease (PD). The inverse relationship between smoking and PD prompted our previous investigation and the report of protective effects of nicot...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033901
更新日期：2007-07-01 00:00:00
abstract：:The 1,2,3,4-tetrahydroisoquinolines (TIQs) are compounds frequently described as alkaloids that can be found in the human body fluids and/or tissues including the brain. In most circumstances, TIQs may be originated as a consequence of reactions, known as Pictet-Spengler condensations, between biogenic amines and elec...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00051-9
更新日期：2019-11-01 00:00:00
abstract：:Reactive oxygen species (ROS) overproduction contributes to the neurotoxicity of 1-methy-4-phenylpyridinium ion (MPP(+)). Increasing studies have shown that hydrogen sulfide (H(2)S) is an endogenous antioxidant gas. We have hypothesized that MPP(+)-caused neurotoxicity may involve the imbalance of proportion to this e...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-010-9180-4
更新日期：2011-04-01 00:00:00
abstract：:Alzheimer's disease is an age-related neurodegenerative disease, associated with the presence of extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles. Although the pathogenesis of AD remains unclear, the characteristic feature of AD was reported to be the buildup of Aβ plaques. In this study, we extensivel...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00321-x
更新日期：2021-01-05 00:00:00
abstract：:Neurological symptoms and cerebral abnormalities are commonly observed in patients with 3-hydroxy-3-methylglutaryl-CoA lyase (HMG lyase) deficiency, which is biochemically characterized by predominant tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), 3-methylglutaric (MGA), and 3-methylglutaconic (MGT) acids. S...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-015-9542-z
更新日期：2015-10-01 00:00:00
abstract：:Multiple system atrophy (MSA) is characterized by the formation of oligodendroglial cytoplasmic inclusions (GCIs) consisting of alpha-synuclein filaments. AlphaB-crystallin, a small chaperone protein that binds to unfolded proteins and inhibits aggregation, has been documented in GCIs. We investigated the relative abu...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033778
更新日期：2005-01-01 00:00:00
abstract：:Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9290-7
更新日期：2012-05-01 00:00:00
abstract：:Neuronal degeneration observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPT...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033264
更新日期：2001-07-01 00:00:00
abstract：:Huntington's disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neur...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-019-00087-x
更新日期：2019-10-01 00:00:00
abstract：:Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male alb...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00231-y
更新日期：2020-08-01 00:00:00
abstract：:Salsolinol (6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline), widely available in many edibles, is considered to alter the function of dopaminergic neurons in the central nervous system and thus, multiple hypotheses on its either physiological and/or pathophysiological role have emerged. The aim of our work was ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00118-7
更新日期：2020-02-01 00:00:00
abstract：:The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induct...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9333-8
更新日期：2013-01-01 00:00:00
abstract：:Alcoholism is associated with a higher incidence of smoking. In addition to the stimulatory effects of both ethanol and nicotine on the mesolimbic reward pathway, nicotine's ability to counteract some of the adverse effects of ethanol (e.g. ataxia) may be a powerful incentive for alcohol consumers to increase their to...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033151
更新日期：2003-01-01 00:00:00
abstract：:Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery occlusion (MCAO) model of stroke. In particular, neuronal cells derived from a human teratocarcinoma cell line, called hNT neurons or LBS neurons (clinical grade prepar...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/10298420290015908
更新日期：2002-03-01 00:00:00
abstract：:Kernicterus is a neurological syndrome associated with indirect bilirubin accumulation and damages to the basal ganglia, cerebellum and brain stem nuclei particularly the cochlear nucleus. To mimic haemolysis in a rat model such that it was similar to what is observed in a preterm human, we injected phenylhydrazine in...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-016-9599-3
更新日期：2016-05-01 00:00:00
abstract：:Glycyrrhizic acid (GA) is the most effective ingredient in the root of licorice, with important pharmacological effects. We investigate the effects of GA on mitochondrial function and biogenesis in the aluminum toxicity in PC12 cell line. After pretreatment of PC12 cells with different concentrations of GA (5-100 μM),...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9967-2
更新日期：2019-04-01 00:00:00
abstract：:Prenatal glucocorticoid (GC) overexposure impacts fetal hippocampal neural stem cells (NSCs) and increases the risk for relative cognitive and mood disorders in offspring. However, the precise underlying mechanisms remain elusive. Here, we treated mouse hippocampal NSCs with dexamethasone (DEX) in vitro and found that...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00294-x
更新日期：2020-10-06 00:00:00
abstract：:Integrin β8 is a key regulator of vascular homeostasis in brain development and in vitro studies show that β8 protects against oxygen-glucose deprivation-induced neuronal apoptosis. However, the role β8 plays in vivo in neonatal rats with hypoxic-ischemic (HI) brain injury is not known. Here, we report the function of...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9312-0
更新日期：2012-11-01 00:00:00
abstract：:Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and abstinence. As human PET data either reflect the impact of chronic nicotine exposure or a pre-existing vulnerability to nicotine addiction, we designed a preclinica...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00055-5
更新日期：2019-11-01 00:00:00
abstract：:It has been shown that a decreased vesicular monoamine transporter (VMAT2) function and the disruption of dopamine (DA) storage is an early contributor to oxidative damage of dopamine neurons in Parkinson's disease (PD). In our previous study, we demonstrated that adenosine A(2A) receptor antagonists suppressed oxidat...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9316-9
更新日期：2012-08-01 00:00:00
abstract：:Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases....
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-019-00044-8
更新日期：2019-10-01 00:00:00
abstract：:Effects of chemotherapeutics on glioma cell lines and spheroids are usually investigated without evaluating the effects of chemotherapeutics on normal brain tissue. To perform such investigations, the aim of this study was to establish a panel of markers for detection of general cell death and more specific neuronal a...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-011-9300-9
更新日期：2012-07-01 00:00:00
abstract：:Epigenetics, or alterations in the phenotype or gene expression due to mechanisms other than changes in the underlying DNA sequence, reflects the sensitivity and responsiveness of human and animal brains in constantly varying circumstances regulating gene expression profiles that define the biomarkers and present the ...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
doi：10.1007/s12640-010-9163-5
更新日期：2010-11-01 00:00:00
abstract：:Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9824-8
更新日期：2018-04-01 00:00:00
abstract：:Maternal hyperhomocysteinemia is one of the common complications of pregnancy that causes offspring cognitive deficits during postnatal development. In the present work, we evaluated the effect of prenatal hyperhomocysteinemia on structural and ultrastructural organization, neuronal and glial cell number, apoptosis (c...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00233-w
更新日期：2020-08-01 00:00:00
abstract：:Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery w...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9827-5
更新日期：2018-05-01 00:00:00
abstract：:Environmental factors and endogenously produced toxins, such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), are considered to be involved in the pathogenesis of Parkinson's disease (PD). In this study, we investigated the impact of single and multiple 1BnTIQ (25 and 50 mg/kg i.p.) administration on L-DOPA-induce...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-014-9476-x
更新日期：2014-10-01 00:00:00
abstract：:In the context of our current knowledge about schizophrenia, heuristic models of psychiatric disorders may be used to test the plausibility of theories developed on the basis of new emerging biological findings, explore mechanisms of schizophrenia-like phenomena, and develop potential new treatments. In a series of st...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1080/1029842021000022089
更新日期：2002-08-01 00:00:00
