Abstract:
:Anesthesia-induced neurotoxicity in immature animals has raised concerns about similar effects occurring in young children. Our study investigated two commonly used anesthetics-sevoflurane and propofol-for neurotoxicity in young children. Forty-seven children (aged 12-36 months) undergoing hypospadias repair surgery were randomized to receive sevoflurane (SG, n = 24) or propofol (PG, n = 23) general anesthesia. Venous blood was collected at three different times-immediately after induction, 2 h, and 3 days after surgery. The cellular portion was assessed for antioxidant defense and DNA damage, using enzyme assay kits and qRT-PCR, respectively, while serum was used to treat cultured neural stem cells (NSCs). MTT assay and TUNEL staining were performed, and the mRNA levels of antioxidant enzymes and apoptosis indicators were evaluated by qRT-PCR. Antioxidant defense and apoptosis status in the SG group were significantly higher than in the PG group at 2 h after surgery. Additionally, exposure of NSCs to postoperative serum of the SG group resulted in decreased cell density and viability, increased TUNEL-positive cells, elevated mRNA levels of antioxidant enzymes, and cleaved caspase-3 expression. Our data shows for the first time that in young children, administration of sevoflurane, but not propofol, leads to temporally increased antioxidant defense and apoptosis status as well as damage of NSCs.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Zhou X,Lu D,Li WD,Chen XH,Yang XY,Chen X,Zhou ZB,Ye JH,Feng Xdoi
10.1007/s12640-017-9827-5subject
Has Abstractpub_date
2018-05-01 00:00:00pages
790-800issue
4eissn
1029-8428issn
1476-3524pii
10.1007/s12640-017-9827-5journal_volume
33pub_type
杂志文章abstract::Parkinson's disease (PD) represents one of the neurodegenerative disorders which are caused by degeneration of dopaminergic neurons in the nigrostriatal pathway. Different toxins, e.g., 6-hydroxydopamine (6-OHDA), are used to model PD in animals. 6-OHDA is a neurotoxin which damages catecholaminergic neurons via produ...
journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-015-9520-5
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-015-9554-8
更新日期:2016-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-009-9008-2
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-019-00118-7
更新日期:2020-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9180-4
更新日期:2011-04-01 00:00:00
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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journal_title:Neurotoxicity research
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journal_title:Neurotoxicity research
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doi:10.1007/s12640-014-9468-x
更新日期:2014-10-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1080/1029842021000022089
更新日期:2002-08-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033166
更新日期:2003-01-01 00:00:00
abstract::Aluminum (Al), a known neurotoxin, has been implicated in Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Parkinsonism Dementia Complex, etc., and it causes extensive damage to the nervous system, including the impairment of learning and memory. However, to date, the mechanism of Al neurotoxicity has no...
journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033913
更新日期:2007-10-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/BF03033183
更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-010-9228-5
更新日期:2011-08-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章
doi:10.1007/s12640-013-9421-4
更新日期:2014-02-01 00:00:00
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journal_title:Neurotoxicity research
pub_type: 杂志文章,评审
doi:10.1007/BF03033386
更新日期:2003-01-01 00:00:00