Abstract：
:Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective effects of Sal and Tyr against focal cerebral ischemia in vivo and H(2)O(2)-induced neurotoxicity in vitro. Sal and Tyr significantly prevented a cerebral ischemic injury induced by a 2 h middle cerebral artery occlusion and a 24 h reperfusion in rats in vivo. Furthermore, the oxidative insult was markedly attenuated by treatments of Sal and Tyr in the cultured rat cortical neurons after a 30 min exposure to 50 μM of H(2)O(2). Western blot analysis revealed that Sal and Tyr decreased the expression of Bax and restored the balance of pro- and anti-apoptotic proteins. The neuroprotective effects of these two analogues show that Tyr has a better antioxidative action compared with Sal both in vivo and in vitro, and suggest that the antioxidant activity of Sal and Tyr may be partly due to their different substituents in their glycosyl groups. This gives a new insight into the development of therapeutic natural antioxidants against oxidative stress.
journal_name
Neurotox Resjournal_title
Neurotoxicity researchauthors
Shi TY,Feng SF,Xing JH,Wu YM,Li XQ,Zhang N,Tian Z,Liu SB,Zhao MGdoi
10.1007/s12640-011-9290-7subject
Has Abstractpub_date
2012-05-01 00:00:00pages
358-67issue
4eissn
1029-8428issn
1476-3524journal_volume
21pub_type
杂志文章abstract：:Microglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-f...
journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-017-9831-9
更新日期：2018-04-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
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更新日期：2002-03-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-018-9979-y
更新日期：2019-04-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00252-7
更新日期：2020-10-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-012-9321-z
更新日期：2013-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033151
更新日期：2003-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/BF03033979
更新日期：2005-11-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章,评审
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journal_title：Neurotoxicity research
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2001-10-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-013-9451-y
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journal_title：Neurotoxicity research
pub_type： 杂志文章
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journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-020-00258-1
更新日期：2020-07-18 00:00:00
abstract：:Poly(ADP-ribose) polymerase (PARP) activation is considered as a major regulator of cell death in various pathophysiological conditions, however, no direct information is available about its role in chronic hypoperfusion-induced neuronal death. Here, we provide evidence for the protective effect of PARP inhibition on ...
journal_title：Neurotoxicity research
pub_type： 杂志文章
doi：10.1007/s12640-009-9049-6
更新日期：2009-07-01 00:00:00
