解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The use of antioxidants has become a common practice in the development of antiaging cosmetics. OBJECTIVE:The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants. METHOD:Thirty-six healthy women from 32 to 65 years were enrolled in...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000508673
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Flare reactions arise due to the release of vasodilators from sensory nerves caused by antidromic transmission of action potentials after the induction of itch. OBJECTIVE:We investigated the link between flare and itch using 3 models of itch. METHODS:Skin provocations with histamine, capsaicin, and cowha...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000508795
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The lipid components and natural moisturizing factors (NMFs) of the stratum corneum (SC) are integral pieces of the self-regulating barrier strategy which comprises one of the most important functions of human skin and seems to be related to biomechanical responses of the SC. OBJECTIVES:This work presents t...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000507456
更新日期:2020-01-01 00:00:00
abstract::Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butyl...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501731
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND AIM:Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical formulation is needed for more appropriate clinical use. For the enhancement of dermal accumulation and prolongation of the pharmacological effe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501734
更新日期:2019-01-01 00:00:00
abstract::The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501976
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects on human health have not been fully investigated. But recently, the influence of VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many of them harmful, c...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501131
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Atopic dermatitis (AD) is a common disease in infancy, for which topical steroids are the first-line therapy but have side effects. Innovative approaches are needed to reduce the burden of AD and corticosteroid usage in infants. METHODS:The once-daily consumption of heat-treated probiotic Lactobacillus...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000499436
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Sesquiterpenes in Curcuma aeruginosa Roxb. inhibit steroid 5α-reductase and dihydrotestosterone production, and reverse androgenic alopecia. This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. METHODS:Thirty women (age 20-52 years) were r...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000486136
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000488250
更新日期:2018-01-01 00:00:00
abstract::Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most c...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000479529
更新日期:2018-01-01 00:00:00
abstract::The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000477417
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS:C...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000455237
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Polymethylmethacrylate (PMMA) plates generally used for the in vitro testing of sunscreens have failed to yield a satisfactory correlation between the sun protection factor (SPF) in vitro and that in vivo. In the present study, various polymers were investigated as alternative substrates to PMMA plates. PROCED...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000464471
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. S...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000477854
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000475472
更新日期:2017-01-01 00:00:00
abstract::Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000452743
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound heal...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000447016
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Advanced glycation end products, which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. Though it is well known that the metabolism of glucose is closely associated with that of fatty acid (FA), sharing the same energy-yielding reaction pathwa...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000448121
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of the study was to elucidate the effect of sample preparation and microscope configuration on the results of confocal Raman microspectroscopic evaluation of the penetration of a pharmaceutical active into the skin (depth profiling). METHODS:Pig ear skin and a hydrophilic formulation containing...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000444806
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship betw...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000443839
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363579
更新日期:2015-01-01 00:00:00
abstract::Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000363149
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Percutaneous penetration of urea in vivo in man has been documented. If urea can penetrate the skin, it may also move laterally. Lateral spreading of topical substances leads to unpredictable penetration dynamics and increased skin surface area exposure. METHODS:The ability of urea, a low molecular-weight h...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363148
更新日期:2015-01-01 00:00:00
abstract::Oral ingestion of collagen peptides (CP) has long been suggested to exert beneficial effects on the skin, but the molecular events induced by CP on the skin remain unclear. Here, we investigated the effects of oral CP administration on gene expression in hairless mouse skin and of prolyl-hydroxyproline (Pro-Hyp), a co...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000369830
更新日期:2015-01-01 00:00:00
abstract:AIM:The purpose of this study was to characterise C₆₀-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. METHODS:Dispersions were characterised according to their pH, particle size, zeta p...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362175
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:The skin has become very attractive as a route for drug administration. Optimization of topical drug formulations by the addition of penetration enhancers may facilitate the passage of drugs through the stratum corneum. METHODS:In this paper, the skin penetration effect of phytosphingosine and 9 derive...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000365730
更新日期:2015-01-01 00:00:00
abstract::Combined ATR-FTIR (attenuated total reflection-Fourier transform infrared) spectroscopy and tape-stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of different surfactants in the stratum corneum (SC). To reveal a possible connection between the size of the formed mice...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000368444
更新日期:2015-01-01 00:00:00
abstract::A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000430101
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available re...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362740
更新日期:2015-01-01 00:00:00
abstract::The skin pH is crucial for physiological skin functions. A decline in stratum corneum acidity, as observed in aged or diseased skin, may negatively affect physiological skin functions. Therefore, glycolic acid-containing water-in-oil (W/O) emulsions adjusted to pH 4 were investigated regarding their effect on normal o...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000439030
更新日期:2015-01-01 00:00:00
abstract::The human skin barrier is an important part of the skin's intactness and its functionality is a precondition for healthy skin. Ingredients in cosmetic formulations, especially penetration enhancers, can influence this barrier function as they transport active agents into deeper skin layers. In this study different cos...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000354919
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Research has revealed new insights into the pathogenesis of psoriasis, leading to new therapeutic options. So far the order of changes in the pathogenesis of psoriasis is unclear. The responses to cutaneous leukotriene B4 (LTB4) application have been studied in the past as an in vivo model for inflammation. ...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000354119
更新日期:2014-01-01 00:00:00
abstract::Carotenoids could serve as marker substances of the antioxidant status of the human skin. In the present study, an optical skin scanner was used to analyse the carotenoid concentration obtained from 4 volunteers over a period of 13 days. The measurements were taken daily at different time points. In addition, the volu...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000357222
更新日期:2014-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi), a relatively new group of epigenetic agents, are being investigated as powerful chemotherapeutics because of their antiproliferative and prodifferentiation effects both in vitro and in vivo, in various tumor cell lines. Only little is known with respect to their effects on norma...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351363
更新日期:2014-01-01 00:00:00
abstract::Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351815
更新日期:2013-01-01 00:00:00
abstract::Brian Barry published over 300 research articles across topics ranging from colloid science, vasoconstriction and the importance of thermodynamics in dermal drug delivery to exploring the structure and organisation of the stratum corneum barrier lipids and numerous strategies for improving topical and transdermal drug...
journal_title:Skin pharmacology and physiology
pub_type: 传,历史文章,杂志文章
doi:10.1159/000351946
更新日期:2013-01-01 00:00:00
abstract::The objective of the present investigation was to examine the utilization of optical and spectroscopic methods for the noninvasive characterization of Anthelios XL Fluide Extreme (SPF 50+), an exemplary sunscreen, concerning its homogeneity of distribution on the skin, its spectroscopic properties and its overall prot...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000343576
更新日期:2013-01-01 00:00:00
abstract:PURPOSE OF THE STUDY:To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity. PROCEDURES:This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and al...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000342124
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIM:The skin, as the outermost organ, protects against exogenous hazards (outside-in barrier) and prevents the loss of essential parts of the body (inside-out barrier). The epidermal barrier exerts several functions with specific morphological elements. Regional differences in skin functions are well known. ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000330721
更新日期:2012-01-01 00:00:00