Abstract:
:Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous cytotoxicology of MMF and tried to characterize its pharmacokinetic effects on the skin using an O/W preparation. An HPLC method has been developed and validated for the detection of MMF in cutaneous tissue, and concentration-time curves of MMF were created after cutaneous application on unaffected as well as lesional skin. Cytotoxicological characterization was carried out using scratch assays on keratinocytes and cutaneous fibroblasts. Results showed that the condition of the skin had no significant impact on the cutaneous bioavailability of MMF, but the intrinsic effect of the O/W vehicle could be utilized in periods of acute inflammation. Cytotoxicological data gave no new indications regarding the safety of MMF.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Wohlrab J,Neubert RH,Sommer E,Michael Jdoi
10.1159/000452743subject
Has Abstractpub_date
2016-01-01 00:00:00pages
273-279issue
5eissn
1660-5527issn
1660-5535pii
000452743journal_volume
29pub_type
杂志文章abstract:BACKGROUND/AIMS:Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. S...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000477854
更新日期:2017-01-01 00:00:00
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abstract::A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 ...
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journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000078822
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abstract:OBJECTIVES:Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. PATIENTS/METHODS:Six volunteers were included in this blinded study. Eleven randomized test s...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
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abstract::The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
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journal_title:Skin pharmacology and physiology
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doi:10.1159/000288165
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000475472
更新日期:2017-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000081115
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship betw...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000443839
更新日期:2016-01-01 00:00:00
abstract::The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501976
更新日期:2019-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000148042
更新日期:2008-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000131077
更新日期:2008-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000508795
更新日期:2020-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363579
更新日期:2015-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000091978
更新日期:2006-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501734
更新日期:2019-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
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journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000324053
更新日期:2011-01-01 00:00:00
abstract:AIM AND METHODS:Drug development in dermatotherapy and also development of transdermal therapeutic systems (TTS) demand high-predictive in vitro models to estimate drug levels in skin and systemic uptake. Here we compare three ready-to-use models, reconstructed human epidermis, split porcine skin and the perfused porci...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000081683
更新日期:2005-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501131
更新日期:2019-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000488250
更新日期:2018-01-01 00:00:00
abstract::A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000109084
更新日期:2008-01-01 00:00:00
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journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000231524
更新日期:2009-01-01 00:00:00
abstract::The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000477417
更新日期:2017-01-01 00:00:00
abstract::In the present study, we investigated the effects of tomato extract (TE) containing lycopene and palm fruit extract (PE) rich in carotenoids on the growth and pigmentation of melanocyte cultures of Caucasian origin. The extracts were tested at different concentrations and in combination with vitamins E and C. Melanocy...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000080217
更新日期:2004-09-01 00:00:00