Abstract:
:Squalene is a major sebum lipid which is easily peroxidized by ultraviolet A (UVA) irradiation, generating products that can stress keratinocytes. Prevention of squalene photooxidation with antioxidants could potentially help defend skin from environmental stress. Previously, we have systematically characterized butylated caffeic acid (BCA) as a more lipophilic alternative of caffeic acid (CA). The current study aimed to test the hypothesis that the lipophilic property of BCA makes it a good candidate as a skin antioxidant. The UVA-induced peroxidation of squalene and the antioxidative activity of CA and BCA were measured for peroxide value and further characterized with ultraperformance liquid chromatography coupled with ultraviolet and mass spectrometry analysis. Both CA and BCA showed strong antioxidant capacity during squalene peroxidation under direct UVA challenge. In HaCaT keratinocyte culture, BCA's and CA's impact on the damage induced by peroxidized squalene (P-SQ) was investigated through quantification of reactive oxygen species (ROS) generation and expression of interleukin-1 (IL-1) cytokines. Both BCA and CA decreased P-SQ-induced IL-1β secretion in HaCaT cells. However, only BCA could reduce P-SQ-induced ROS generation as well as expression of inflammatory cytokines in the IL-1 family. This advantage in biological efficacy could have been attributed to BCA's superior intracellular bioavailability due to its higher lipophilicity compared with CA, as indicated by higher intracellular concentration of BCA. Based on this observation, we propose using BCA as a functional antioxidant to prevent sebum lipid from peroxidation and its detrimental effect to skin.
journal_name
Skin Pharmacol Physioljournal_title
Skin pharmacology and physiologyauthors
Zhou D,Weng Xdoi
10.1159/000501731subject
Has Abstractpub_date
2019-01-01 00:00:00pages
307-317issue
6eissn
1660-5527issn
1660-5535pii
000501731journal_volume
32pub_type
杂志文章abstract::Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and t...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000183924
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000231524
更新日期:2009-01-01 00:00:00
abstract::Combined ATR-FTIR (attenuated total reflection-Fourier transform infrared) spectroscopy and tape-stripping experiments in vitro on porcine ear skin were used to investigate the spatial distribution of different surfactants in the stratum corneum (SC). To reveal a possible connection between the size of the formed mice...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000368444
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Retinoic acid (RA) and benzoyl peroxide (BP) were studied, comparing their keratolytic efficacy and water barrier disruption to that of salicylic acid (SA), a well-established keratolytic, under similar conditions. PATIENTS/METHODS:Six volunteers were included in this blinded study. Eleven randomized test s...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093984
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To use high-speed differential scanning calorimetry (DSC) in the identification of transitions in human stratum corneum (SC). Several scanning rates (100 degrees C/min to 400 degrees C/min) are used. RESULTS:Eight transitions from 0 to 120 degrees C are detected in a significant number of samples. Most of thes...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000092593
更新日期:2006-01-01 00:00:00
abstract::The aim of this work was to investigate in vitro the transdermal permeation of caffeine from a new bioadhesive film, using rabbit ear skin as a barrier. The effects of film composition and of the presence of penetration enhancers in the formulation were studied. The obtained fluxes were compared with those shown by co...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000077237
更新日期:2004-05-01 00:00:00
abstract::The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In a...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000477417
更新日期:2017-01-01 00:00:00
abstract::In a clinical study, the skin penetration properties of melatonin 0.01% in a cream and 0.01 and 0.03% in a solution were investigated by evaluation of the serum melatonin levels over a 24-hour time course in 15 healthy volunteers. Blood samples for melatonin measurements were taken at 9.00 a.m. before applying the tes...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000078822
更新日期:2004-07-01 00:00:00
abstract::Despite its remarkable barrier function, the skin remains an attractive site for systemic drug delivery given its easy accessibility, large surface area and the possibility to bypass the gastrointestinal tract and the liver and so modify drug absorption kinetics. The pioneering work of Scheuplein, Higuchi and others i...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000351815
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND AIM:Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical formulation is needed for more appropriate clinical use. For the enhancement of dermal accumulation and prolongation of the pharmacological effe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501734
更新日期:2019-01-01 00:00:00
abstract::Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000363149
更新日期:2015-01-01 00:00:00
abstract::In animal wound models, accelerated wound closure has been shown by use of polihexanide applied in antimicrobially effective concentrations. Additionally, an increased ATP production of keratinocytes in vitro induced by polihexanide was demonstrated and interpreted as a stimulatory effect on cell proliferation. Based ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000319602
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:Keloids result from aberrations in the normal wound healing cascade and can lead to pruritus, contractures and pain. The underlying mechanisms of excessive scarring are not yet understood, and most therapeutic strategies remain unsatisfactory. Psoriasin (S100A7) and koebnerisin (S100A15) are released by...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000363579
更新日期:2015-01-01 00:00:00
abstract::The aim of the study was to assess an Ectoin formulation with regard to the antiageing properties. The study was designed as a monocentric, randomized, double-blind application test, in order to ensure the compatibility and the efficacy of Ectoin in comparison to a vehicle emulsion. A total of 104 voluntary healthy fe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000103204
更新日期:2007-01-01 00:00:00
abstract::Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoest...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000324053
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing process affects the penetration of chemicals; therefore, we evaluated whe...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000475472
更新日期:2017-01-01 00:00:00
abstract::The pH of the skin is tightly regulated by endogenous buffering systems. We examined the influence of buffers of different pH and composition on skin barrier repair, pH, inflammation, and epidermal thickness/proliferation/differentiation. After tape-stripping in hairless mice buffers with pH 4-7 were applied in patch ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000501976
更新日期:2019-01-01 00:00:00
abstract::The objective of the present investigation was to examine the utilization of optical and spectroscopic methods for the noninvasive characterization of Anthelios XL Fluide Extreme (SPF 50+), an exemplary sunscreen, concerning its homogeneity of distribution on the skin, its spectroscopic properties and its overall prot...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章
doi:10.1159/000343576
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of the study was to elucidate the effect of sample preparation and microscope configuration on the results of confocal Raman microspectroscopic evaluation of the penetration of a pharmaceutical active into the skin (depth profiling). METHODS:Pig ear skin and a hydrophilic formulation containing...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000444806
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. METHODS:We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000106075
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available re...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000362740
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Advanced glycation end products, which are linked to both aging and hyperglycemia, cause marked functional and structural alterations in human skin. Though it is well known that the metabolism of glucose is closely associated with that of fatty acid (FA), sharing the same energy-yielding reaction pathwa...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000448121
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS:C...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000455237
更新日期:2017-01-01 00:00:00
abstract::A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 ...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000430101
更新日期:2015-01-01 00:00:00
abstract::The cyclicity of time affects virtually all aspects of our being and is the basis of the underlying rhythmicity which is typical of our lives. To 'tell time', most living organisms use internal timing mechanisms known as 'biological clocks'. These 'clocks' coordinate our physiological and behavioral functions and inte...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000093113
更新日期:2006-01-01 00:00:00
abstract::A screen for natural products bearing pharmacological properties has yielded a secretion of the mollusk Cryptomphalus aspersa (SCA), which possesses skin-regenerative properties. In this report, we outline some of the cellular and molecular effects underlying this observation. First, we found that SCA contained antiox...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000109084
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Dry skin induced by rheumatoid arthritis (RA) causes itching, which negatively influences a patient's quality of life. We previously reported that mast cells are related to dry skin in arthritic mice. However, the mechanism of mast cell activation is unclear. In this study, we examined the mechanism underlyi...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章
doi:10.1159/000488250
更新日期:2018-01-01 00:00:00
abstract::Biogenic amines are potential irritants e.g. in fish-, meat-, milk- and egg-processing professions like cooks, butchers and bakers. The aim of this study was to test the irritative and barrier-disrupting properties of the biogenic amines ammonium hydroxide (AM), dimethylamine (DMA) and trimethylamine (TMA). A repeated...
journal_title:Skin pharmacology and physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000083709
更新日期:2005-03-01 00:00:00
abstract::Along with antibiotics, antihistamines are the most widely used systemic drugs in dermatology. This is attributable to the major role played by histamine in common diseases such as urticaria and atopic eczema. Of the currently recognised four subtypes of G protein-coupled histamine receptors, only the H1 and H2 subtyp...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,评审
doi:10.1159/000086667
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. METHODS:Fifty-seven healthy full-term neonates aged < or = 48 h were randomly as...
journal_title:Skin pharmacology and physiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235552
更新日期:2009-01-01 00:00:00